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1,2-alpha-D-mannobiose + H2O
alpha-D-mannose
-
-
-
?
1,3-alpha-D-mannobiose + H2O
alpha-D-mannose
-
-
-
?
1,6-alpha-D-mannobiose + H2O
alpha-D-mannose
-
-
-
?
1-naphthyl-alpha-D-mannopyranoside + H2O
1-naphthol + alpha-D-mannopyranose
-
-
-
?
2 Man9GlcNAc + 3 H2O
Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose
-
-
products from unbound fraction of cobalt-chelating Sepharose
?
2,4-dinitrophenyl alpha-D-mannopyranoside + H2O
2,4-dinitrophenol + alpha-D-mannopyranose
2,4-dinitrophenyl alpha-D-mannoside + H2O
2,4-dinitrophenol + alpha-D-mannose
-
-
-
-
?
2,4-dinitrophenyl-alpha-D-mannopyranoside + H2O
2,4-dinitrophenol + alpha-D-mannopyranose
-
-
-
-
?
2,5-dinitrophenyl-alpha-D-mannopyranoside + H2O
2,5-dinitrophenol + D-mannose
-
-
-
-
?
2-acetamido-4-O-alpha-D-mannopyranosyl-2-deoxy-D-glucose + H2O
alpha-D-mannopyranose + ?
-
-
-
?
2-deoxy-2-fluoro-alpha-D-mannosyl fluoride + H2O
?
-
substrate for wild-type enzyme and very slow substrate of mutant enzyme D341N
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose + D-mannopyranose
2-O-alpha-D-mannopyranosyl-D-mannose + H2O
D-mannose
2-O-alpha-D-mannotriose + H2O
alpha-D-mannopyranose + ?
-
highly specific for alpha-1,2-mannosidic linkages
-
?
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose + H2O
alpha-D-mannopyranose
the enzyme is only active with the alpha-1,3-linked disaccharide
-
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferol + alpha-D-mannopyranose
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannose
-
pH 6.5, 50°C, 15 min, reaction stopped with Na2CO3
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside
?
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + D-mannose
-
-
-
-
?
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + D-mannose
4-nitrophenyl alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + D-mannose
-
-
-
-
?
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenyl + alpha-D-mannose
-
-
-
-
?
4-nitrophenyl-alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
4-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
specific cleavage of alpha-1,4- or alpha-1,6-linkages
-
?
5-fluoro-beta-L-gulosyl fluoride + H2O
?
-
acts as a slow substrate for the D341 mutant enzyme, with deglycosylation as the rate-limiting step. Inactivation is only observed when assayed at low temperatures such that deglycosylation is slow relative to the assay time
-
-
?
6 pyridylamino-Man9GlcNAc2 + H2O
pyridylamino-Man8GlcNAc2 + pyridylamino-Man7GlcNAc2 + pyridylamino-Man6GlcNAc2 + pyridylamino-Man5GlcNAc2 + pyridylamino-Man4GlcNAc2 + pyridylamino-Man3GlcNAc2 + 21 alpha-D-mannopyranose
6-bromo-2-naphthyl-alpha-D-mannopyranoside + H2O
6-bromo-2-naphthol + alpha-D-mannopyranose
-
-
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
alpha-(1-2)-mannobiose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
-
-
?
alpha-(1-3)-mannobiose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
highest activity and affinity
-
?
alpha-(1-6)-mannobiose
alpha-D-mannopyranose + D-mannopyranose
-
low activity
-
?
alpha-(1-6)-mannobiose + H2O
alpha-D-mannopyranose
-
low activity
-
?
alpha-conglutin + H2O
alpha-D-mannopyranose + ?
-
lupin seed storage glycoprotein, not active to beta- or gamma-conglutin
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O
alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man
-
cleaves asparagine-linked high mannose oligosaccharides to form the core Man3GlcNAc2
-
?
alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O
alpha-D-mannose + ?
alpha-D-Man-(1->2)-D-Man + H2O
2 alpha-D-mannose
alpha-D-Man-(1->3)-D-Man + H2O
2 alpha-D-mannose
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O
alpha-D-mannose + ?
-
-
-
?
alpha-D-Man-(1->4)-D-Man + H2O
2 alpha-D-mannose
alpha-D-Man-(1->6)-D-Man + H2O
2 alpha-D-mannose
alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + ?
-
-
?
alpha-D-mannosidosis fibroblasts + H2O
Man7-2GlcNAc + ?
-
-
-
?
alpha-D-mannosidosis fibroblasts + H2O
Manbeta(1-4)GlcNAc + ?
-
-
?
alpha-D-Manp-(1-2)-D-Manp + H2O
D-mannose + ?
alpha3,alpha6-D-mannopentaose + H2O
alpha-D-mannose
-
-
-
?
baker's yeast mannan + H2O
? + D-mannose
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
GDP-mannosylpyranose + H2O
alpha-D-mannosylpyranose + GDP
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
glycopeptide + H2O
alpha-D-mannopyranose + ?
glycoprotein + H2O
alpha-D-mannopyranose + ?
high mannose N-glycan + H2O
?
-
-
-
?
Man-alpha(1-3)Man + H2O
alpha-D-mannose
-
pH 6.5, 50°C, 20 min
-
-
?
Man-alpha(1-6)Man + H2O
alpha-D-mannose
-
pH 6.5, 50°C, 20 min
-
-
?
Man-alpha-(1-2)-Man-alpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-3)]-Manalpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-2)-Man-alpha-(1-3)]-Man-beta(1-4)GlcNAc + H2O
?
-
-
-
-
?
Man-alpha-(1-2)-Man-alpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-3)]-Manalpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-2)-Man-alpha-(1-3)]-Man-beta(1-4)GlcNAc + H2O
Man-alpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-2)-Man-alpha(1-3)]-Man-beta-(1-4)-GlcNAc + alpha-mannose
-
-
end product in presence of Co2+. Before treatment with Co(II) the enzyme is able to cleave a single Manalpha1-2 residue from the substrate to give Man-alpha(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-3)]Man-alpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-2)-Man-alpha-(1-3)]Man-beta-(1-4)-GlcNAc as the end product
-
?
Man-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
low activity
-
?
Man3GlcNAc2 + H2O
Man2GlcNAc2 + alpha-D-mannopyranose
-
Man-1,6-linkage only hydrolysed after its Man-1,3-residue is removed
-
?
Man5-9GlcNAc + H2O
alpha-D-mannopyranose + ?
-
low activity for Man5GlcNAc
-
?
Man5GlcNAc + 2 H2O
Man3GlcNAc + 2 alpha-D-mannopyranose
-
-
-
?
Man5GlcNAc2 + 2 H2O
Man3GlcNAc2 + 2 alpha-D-mannopyranose
-
-
-
?
Man5GlcNAc2 + 2 H2O
Man3GlcNAc2 + 2 mannose
Man5GlcNAc2 + H2O
Man4GlcNAc2 + alpha-D-mannopyranose
-
cleaves Man-alpha-(1-3)-linkage 10times faster than the Man-1,6 and the Man-1,2-linkages
mixture of three isomeric oligosaccharides
?
Man6 + H2O
alpha-D-mannose + ?
-
derived from ovalbumin, alpha-1,2: 1,3: 1,6-linkages, more than 10fold higher specific activity for isoform EII than for EI
-
?
Man6-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
Man6GlcNAc2 + H2O
Man5GlcNAc2 + mannose
-
slow reaction of the Golgi alpha-mannosidase in vitro
-
-
?
Man6GlcNAc2 + n H2O
Man(6-n)GlcNAc2 + n mannose
-
-
-
-
?
Man7GlcNAc + 2 H2O
Man5GlcNAc + 2 alpha-D-mannopyranose
-
-
-
?
Man7GlcNAc2 + H2O
Man-GlcNAc2 + mannose
-
-
-
-
?
Man8GlcNAc + 3 H2O
Man5GlcNAc + 3 alpha-D-mannopyranose
-
-
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 alpha-D-mannopyranose
-
-
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 D-mannose
Man8GlcNAc2 + H2O
Man-GlcNAc2 + mannose
-
-
-
-
?
Man9-5GlcNAc + 4 H2O
Man5-3GlcNAc + 4 alpha-D-mannopyranose
-
different product composition for alpha-mannosidases IA, IB and II
-
?
Man9-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
Man9GlcNAc + H2O
Manalpha(1-6)[Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAc + alpha-D-mannopyranose
-
Co2+ activated alpha-mannosidase
end products
?
Man9GlcNAc2 + 3 H2O
Man6GlcNAc2 + 3 mannose
-
fast reaction of the Golgi alpha-mannosidase in vitro
-
-
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
Manalpha(1-2)Man + H2O
D-mannose
-
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Man(1-6)]ManbetaGlcNac-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manbeta(1-6)]ManbetaGlcNAc-beta-GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-6)Manalpha(1-4)-anhydromannitol + H2O
Manalpha(1-2)Manalpha(1-6)Manalpha(1-4)-anhydromannitol + Manalpha(1-6)Manalpha(1-4)-anhydromannitol + Manalpha(1-4)anhydromannitol + anhydromannitol + alpha-D-mannose
-
-
equal amounts, but only traces of Manalpha(1-4)-anhydromannitol
?
Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-3)[Man(1-6)]ManbetaGlcNAc-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
(Man)6(GlcNAc)2 + D-mannose
-
highly active on alpha(1-2) linked mannooligosaccharides
-
-
?
Manalpha(1-3)GlcNAc + H2O
alpha-D-mannopyranose + 2-acetylamino-2-deoxy-D-glucose
-
-
-
?
Manalpha(1-3)GlcNAc + H2O
alpha-D-mannopyranose + N-acetyl-D-glucosamine
-
-
-
?
Manalpha(1-3)Man + H2O
D-mannose
-
-
-
-
?
Manalpha(1-3)[Man(1-6)]ManbetaGlcNAc-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-4)Manbeta(1-4)Man + H2O
alpha-D-mannopyranose + Manbeta(1-4)Man
-
-
-
?
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
(Man)5(GlcNAc)2-Asn + D-mannose
-
i.e. GPIV
-
?
Manalpha(1-6)GlcNAc + H2O
alpha-mannopyranose + 2-acetylamino-2-deoxy-D-glucose
-
-
-
?
Manalpha(1-6)GlcNAc + H2O
alpha-mannopyranose + N-acetyl-D-glucosamine
-
-
-
?
Manalpha(1-6)Man + H2O
D-mannose
-
-
-
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-)]Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
4 times faster hydrolysis than Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha1-2Man + H2O
alpha-mannose
-
-
-
-
?
Manalpha1-3Man + H2O
alpha-mannose
-
-
-
-
?
Manalpha1-6Man + H2O
alpha-mannose
-
-
-
-
?
mannan + H2O
alpha-D-mannose + ?
mannobiose + H2O
?
-
-
-
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
mannosyl rhamnose + H2O
alpha-D-mannopyranose + rhamnose
-
part of the repeating oligosaccharide unit of the O-antigenic lipopolysaccharide in Salmonella typhimurium
-
?
mannosyl(5)-N-acetyl-glucosamine-pyridylamino + H2O
mannosyl(4)-N-acetyl-glucosamine-pyridylamino + mannosyl(3)-N-acetyl-glucosamine-pyridylamino
-
occurrence of mannosyl(4)-N-acetyl-glucosamine-pyridylamino (32%) and mannosyl(3)-N-acetyl-glucosamine-pyridylamino (8.1%) are observed only in the presence of Co2+
-
?
mannosyl(9)-N-acetyl-glucosamine + 4 H2O
mannosyl(5)-N-acetyl-glucosamine + 4 alpha-D-mannose
in presence of Co2+
-
-
?
mannosyl(9)-N-acetyl-glucosamine + H2O
mannosyl(8)-N-acetyl-glucosamine + alpha-D-mannose
absence of Co2+
-
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
mannotriose + H2O
alpha-D-mannopyranose + mannobiose
-
-
-
?
methyl-2,4,6-tri-O-methyl-D-mannopyranoside + H2O
2,4,6-tri-O-methyl-D-mannopyranose + methanol
-
-
-
?
methyl-2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside + H2O
? + D-mannose
-
-
-
-
?
methyl-2-O-alpha-D-mannopyranosyl-D-mannopyranoside + H2O
alpha-D-mannopyranose + ?
-
very low activity
-
?
methyl-4-O-alpha-D-mannopyranosyl-D-mannopyranoside + H2O
alpha-D-mannopyranose + ?
-
-
-
?
methyl-alpha-D-mannnopyranose + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
methyl-O-1,4-alpha-D-mannobiose + H2O
alpha-D-mannose
-
-
-
?
p-nitrophenyl alpha-D-rhamnopyranoside + ethyl 1-thio-alpha-D-rhamnopyranoside
p-nitrophenol + ethyl alpha-D-rhamnopyranosyl-(1-2)-1-thio-alpha-D-rhamnopyranoside
-
-
-
-
?
p-nitrophenyl alpha-mannoside + H2O
p-nitrophenol + alpha-mannose
-
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannose
-
-
-
-
?
p-nitrophenyl-alpha-D-mannoside + H2O
4-nitrophenol + D-mannose
-
-
-
-
?
p-nitrophenyl-alpha-D-mannoside + H2O
p-nitrophenol + alpha-D-mannose
-
-
-
-
?
phenyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + phenol
-
-
-
?
pyridylamino-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
pyridylamino-Man5GlcNAc + 3 H2O
pyridylamino-Man2GlcNA + alpha-D-mannopyranose
-
-
-
?
pyridylamino-Man5GlcNAc + H2O
pyridylamino-Man4GlcNAc + pyridylamino-Man3-2GlcNAc + alpha-D-mannose
-
lesser degree of pyridylamino-Man3-2GlcNAc, stepwise cleavage to Man2GlcNAc structures
?
pyridylamino-Man9GlcNAc2 + H2O
pyridylamino-Man8GlcNAc2 + alpha-D-mannopyranose
-
high amounts of substrate hydrolysed at neutral pH, very little cleavage at pH 3.0
hydrolysis products within 20 min
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
RNase-B-Man(n)-glycoform + H2O
RNase-B-Man(n-1)-glycoform + alpha-D-mannose
-
-
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
thyroglobulin + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
additional information
?
-
2,4-dinitrophenyl alpha-D-mannopyranoside + H2O
2,4-dinitrophenol + alpha-D-mannopyranose
-
-
-
-
?
2,4-dinitrophenyl alpha-D-mannopyranoside + H2O
2,4-dinitrophenol + alpha-D-mannopyranose
-
-
-
-
?
2,4-dinitrophenyl alpha-D-mannopyranoside + H2O
2,4-dinitrophenol + alpha-D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
highly specific for alpha-1,2-mannosidic linkages
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
very low activity
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
highly specific for alpha-1,2-mannosidic linkages
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannose + H2O
D-mannose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannose + H2O
D-mannose
-
i.e. alpha-D-Man-(1-2)-D-Man
-
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferol + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferol + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
-
?
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + alpha-D-mannopyranose
-
-
-
?
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
-
-
-
?
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
-
-
-
?
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + D-mannose
-
-
-
-
?
4-nitrophenyl alpha-D-mannopyranoside + H2O
4-nitrophenol + D-mannose
-
-
-
-
?
4-nitrophenyl alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
-
-
-
?
4-nitrophenyl alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
no hydrolysis observed on 4-nitrophenyl alpha-D-glucoside, 4-nitrophenyl alpha-D-galactoside, 4-nitrophenyl alpha-D-xyloside, 4-nitrophenyl alpha-L-arabinoside, 4-nitrophenyl alpha-L-rhamnoside, 4-nitrophenyl alpha-L-fucoside, and 4-nitrophenyl beta-L-fucoside
-
-
?
4-nitrophenyl alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
no hydrolysis observed on 4-nitrophenyl alpha-D-glucoside, 4-nitrophenyl alpha-D-galactoside, 4-nitrophenyl alpha-D-xyloside, 4-nitrophenyl alpha-L-arabinoside, 4-nitrophenyl alpha-L-rhamnoside, 4-nitrophenyl alpha-L-fucoside, and 4-nitrophenyl beta-L-fucoside
-
-
?
4-nitrophenyl alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
-
-
-
?
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
-
able to protect enzyme from quenching of fluorescence
-
-
?
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
-
activity measured in whole fly homogenates, substrate concentration of 60 mM in citrate buffer, female oasis flies have 90% less alpha-mannosidase than females from the arid desert, flies of arid regions tend to produce more alpha-mannosidase activity than those originating in sugar-rich environments
-
-
?
4-nitrophenyl-alpha-D-mannopyranoside + H2O
4-nitrophenol + alpha-D-mannopyranose
-
-
-
-
?
4-nitrophenyl-alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
-
-
-
-
?
4-nitrophenyl-alpha-D-mannoside + H2O
4-nitrophenol + alpha-D-mannose
pNP-alpha-Man, used for enzyme activity test
-
-
?
6 pyridylamino-Man9GlcNAc2 + H2O
pyridylamino-Man8GlcNAc2 + pyridylamino-Man7GlcNAc2 + pyridylamino-Man6GlcNAc2 + pyridylamino-Man5GlcNAc2 + pyridylamino-Man4GlcNAc2 + pyridylamino-Man3GlcNAc2 + 21 alpha-D-mannopyranose
-
-
-
?
6 pyridylamino-Man9GlcNAc2 + H2O
pyridylamino-Man8GlcNAc2 + pyridylamino-Man7GlcNAc2 + pyridylamino-Man6GlcNAc2 + pyridylamino-Man5GlcNAc2 + pyridylamino-Man4GlcNAc2 + pyridylamino-Man3GlcNAc2 + 21 alpha-D-mannopyranose
stepwise cleavage to Man2GlcNAc structures
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
-
very low activity
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
-
specific cleavage of alpha-1,4- or alpha-1,6-linkages
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
-
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
-
end products
?
alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O
alpha-D-mannose + ?
-
-
-
?
alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O
alpha-D-mannose + ?
-
-
-
?
alpha-D-Man-(1->2)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->2)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->3)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->3)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->4)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->4)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->6)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Man-(1->6)-D-Man + H2O
2 alpha-D-mannose
-
-
-
?
alpha-D-Manp-(1-2)-D-Manp + H2O
D-mannose + ?
-
-
-
-
?
alpha-D-Manp-(1-2)-D-Manp + H2O
D-mannose + ?
-
-
-
-
?
baker's yeast mannan + H2O
? + D-mannose
-
-
-
-
?
baker's yeast mannan + H2O
? + D-mannose
-
releases 9.2% of total mannose
-
-
?
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannosylpyranose + GDP
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannosylpyranose + GDP
-
-
-
?
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
-
low activity
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
faster hydrolysis than for glycoprotein
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
contains only alpha-1,2-linked mannose residues, highly specific on alpha-1,2-linked mannooligosaccharides
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
stem bromelain
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
-
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
ovomucoid, orosomucoid, ovalbumin
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man5GlcNAc2 + 2 H2O
Man3GlcNAc2 + 2 mannose
-
-
-
-
?
Man5GlcNAc2 + 2 H2O
Man3GlcNAc2 + 2 mannose
-
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
-
ordered hydrolysis of alpha(1-2)-residues followed by hydrolysis of alpha(1-3)- and alpha(1-6)-linked residues
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 D-mannose
-
Golgi alpha-mannosidase in vivo
-
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 D-mannose
-
slow reaction of the endoplasmic reticulum alpha-mannosidase in vitro
-
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
-
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
-
end product for Tris-eluted isoform, representing the Man5-oligosaccharide chain of the dolichol pathway formed in the cytosolic compartment during biosynthesis of N-glycosylprotein glycans
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
hydrolyses alpha-1,2- and alpha-1,3-linkages
after 24 h incubation, specifically removes alpha-1,2-linked mannoses
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
-
involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages
major product: Man6GlcNAc2
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
-
-
major product: Man5GlcNAc2, involved in Asn-linked oligosaccharide maturation
?
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
-
Man8GlcNAc B isomer + mannose is produced after 12 h at 37°C. Prolonged incubation results in accumulation after 24 h of Man7GlcNAc2 and probably Man6GlcNAc2
-
?
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
endoplasmic reticulum alpha-mannosidase in vivo
-
-
?
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
fast reaction of the endoplasmic reticulum alpha-mannosidase in vitro
-
-
?
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
-
-
-
?
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
-
-
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
only mannose librated
?
mannan + H2O
alpha-D-mannose + ?
-
from baker's and sake yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
specific for alpha-1,2-linked mannopyranosyl residues
-
?
mannan + H2O
alpha-D-mannose + ?
-
derived from wild type or mutant strains of Saccharomyces cerevisiae, different specific activities for isoforms EI and EII, depending on the type of alpha-D-linkages of mutant substrates, preference for cleavage of alpha-1,6- and alpha-1,3-linkages
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
yeast alpha-mannan, main product: alpha-D-mannose, hydrolysis of linear and branched mannans containing terminal alpha-1,2- and alpha-1,3-linked mannopyranosyl residues
-
?
mannan + H2O
alpha-D-mannose + ?
-
very low activity
-
?
mannan + H2O
alpha-D-mannose + ?
-
very low activity
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
from baker's and sake yeast
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
reverse action on alpha-D-mannopyranose, 85%, w/w, yields 0.93 M disaccharide with 4 different isomers, 0.61 M trisaccharide, 0.25 M tetrasaccharide and higher oligosaccharides, retention of anomeric configuration
-
r
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, hydrolysis of alpha-1,2- and alpha-1,3-linkages
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, hydrolysis of alpha-1,2- and alpha-1,3-linkages
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, a tetrasaccharide terminating in a mannopyranosyl residue linked to C-3 of its neighbour is not hydrolysed
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
-
-
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
methyl-alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + methanol
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
very low activity
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
most rapidly hydrolysed
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
very poor substrate
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
different affinities for two isoforms, unbound fraction and Tris-eluted fraction from cobalt-chelating Sepharose
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
responsible for the removal of mannose residues from asparagines-linked high-mannose type oligosaccharides prior to their entry into the Golgi
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
isoforms mannosidase IB and II
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
high amounts of substrate hydrolysed at pH 3.0, at neutral pH very little substrate cleaved
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
p-nitrophenyl-alpha-D-mannopyranoside + H2O
p-nitrophenol + alpha-D-mannopyranose
-
-
-
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
-
from bovine pancreas
single oligosaccharide component
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
-
-
-
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
from Aspergillus oryzae, hydrolysis of a single Man-1,2-linkage
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
additional information
?
-
-
no substrate: 3-O-alpha- and 6-O-alpha-D-mannobioses
-
-
?
additional information
?
-
-
the enzyme is involved in ordered degradation of glycoproteins, inborn enzyme-deficiency results in lysosomal storage disorder alpha-mannosidosis
-
-
?
additional information
?
-
-
broad substrate specific exoglycosidase
-
-
?
additional information
?
-
-
no hydrolysis of Man6GlcNAc2-ASn, man5-GlcNAc2-ASn, and alpha1,3- and alpha1-6-linked mannobiosides
-
-
?
additional information
?
-
-
enzyme processes alpha1,6-mannobiose into the product mannose. No activity on alpha1,2-mannobiose, alpha1,3-mannobiose or alpha(1,3)/(1,6)-mannotriose
-
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
key enzyme in N-glycan processing
-
-
?
additional information
?
-
-
anomalies of the enzyme system detected in patients with amyotrophic lateral sclerosis could reflect a situation of progressive injury of proteins
-
-
?
additional information
?
-
-
the enzyme is required in the degradation of the asparagine-linked carbohydrates of glycoproteins. Deficiency of this enzyme leads to the lysosomal storage disorder alpha-mannosidosis
-
-
?
additional information
?
-
-
class 1 alpha1,2-mannosidases of glycosylhydrolase family 47 play critical roles in the maturation of Asn-linked glycoproteins in the endoplasmic reticulum and Golgi complex as well as in the recognition and timing of disposal of terminally unfolded proteins by ER-associated degradation, overview
-
-
?
additional information
?
-
-
digestion of glycopeptides having high mannose-type sugar chains
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze alpha-D-Manp-(1-3)-D-Manp and alpha-D-Manp-(1-6)-D-Manp
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze alpha-D-Manp-(1-3)-D-Manp and alpha-D-Manp-(1-6)-D-Manp
-
-
?
additional information
?
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
-
enzyme hydrolyzes alpha-mannosidase linkages from both high-mannose type and plant complex type N-glycan, but prefers a truncated plant complex type structure to high-mannose type N-glycans bearing alpha-(1,2)-mannosyl residues
-
-
?
additional information
?
-
-
enzyme is active toward both high-mannose type and truncated plant complex type N-glycans. It prefers truncated plant complex type N-glycans
-
-
?
additional information
?
-
-
enzyme cleaves alpha1-2, 1-3 and 1-6 mannosidic linkage from both high-mannose and truncated complex-type N-glycans
-
-
?
additional information
?
-
-
no hydrolysis of GlcNAcMan5GlcNAc2
-
-
?
additional information
?
-
-
enzyme processes alpha1,6-mannobiose into the product mannose. No activity on alpha1,2-mannobiose, alpha1,3-mannobiose or alpha(1,3)/(1,6)-mannotriose
-
-
?
additional information
?
-
higher eukaryotic GH38 alpha-mannosides play a key role in the modification and diversification of hybrid N-glycans, processes with strong cellular links to cancer and autoimmune disease
-
-
?
additional information
?
-
SpGH38 is an alpha-mannosidase with specificity for alpha-1,3 mannosidic linkages, active site structure, overview
-
-
?
additional information
?
-
-
the exo-type cytosolic class II enzyme cleaves off alpha-1,2-, alpha-1,3-, and alpha-1,6-mannose residues
-
-
?
additional information
?
-
-
more specific towards Man-alpha-1,2-bonds, but also hydrolysis of alpha-1,3- and of alpha-1,6-bonds
-
-
?
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2 Man9GlcNAc + 3 H2O
Man8GlcNAc + Man7GlcNAc + 3 alpha-D-mannopyranose
-
-
products from unbound fraction of cobalt-chelating Sepharose
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
2-O-alpha-D-mannotriose + H2O
alpha-D-mannopyranose + ?
-
highly specific for alpha-1,2-mannosidic linkages
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
4-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
specific cleavage of alpha-1,4- or alpha-1,6-linkages
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
alpha-(1-2)-mannobiose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
-
-
?
alpha-(1-3)-mannobiose + H2O
alpha-D-mannopyranose + D-mannopyranose
-
highest activity and affinity
-
?
alpha-(1-6)-mannobiose
alpha-D-mannopyranose + D-mannopyranose
-
low activity
-
?
alpha-conglutin + H2O
alpha-D-mannopyranose + ?
-
lupin seed storage glycoprotein, not active to beta- or gamma-conglutin
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O
alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man
-
cleaves asparagine-linked high mannose oligosaccharides to form the core Man3GlcNAc2
-
?
alpha-D-mannopyranoside + H2O
alpha-D-mannopyranose + ?
-
-
?
alpha-D-mannosidosis fibroblasts + H2O
Man7-2GlcNAc + ?
-
-
-
?
alpha-D-mannosidosis fibroblasts + H2O
Manbeta(1-4)GlcNAc + ?
-
-
?
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
glycopeptide + H2O
alpha-D-mannopyranose + ?
glycoprotein + H2O
alpha-D-mannopyranose + ?
high mannose N-glycan + H2O
?
-
-
-
?
Man-alpha-(1-2)-Man-alpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-3)]-Manalpha-(1-6)-[Man-alpha-(1-2)-Man-alpha-(1-2)-Man-alpha-(1-3)]-Man-beta(1-4)GlcNAc + H2O
?
-
-
-
-
?
Man-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
low activity
-
?
Man3GlcNAc2 + H2O
Man2GlcNAc2 + alpha-D-mannopyranose
-
Man-1,6-linkage only hydrolysed after its Man-1,3-residue is removed
-
?
Man5-9GlcNAc + H2O
alpha-D-mannopyranose + ?
-
low activity for Man5GlcNAc
-
?
Man5GlcNAc + 2 H2O
Man3GlcNAc + 2 alpha-D-mannopyranose
-
-
-
?
Man5GlcNAc2 + 2 H2O
Man3GlcNAc2 + 2 alpha-D-mannopyranose
-
-
-
?
Man5GlcNAc2 + H2O
Man4GlcNAc2 + alpha-D-mannopyranose
-
cleaves Man-alpha-(1-3)-linkage 10times faster than the Man-1,6 and the Man-1,2-linkages
mixture of three isomeric oligosaccharides
?
Man6 + H2O
alpha-D-mannose + ?
-
derived from ovalbumin, alpha-1,2: 1,3: 1,6-linkages, more than 10fold higher specific activity for isoform EII than for EI
-
?
Man6-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
Man7GlcNAc + 2 H2O
Man5GlcNAc + 2 alpha-D-mannopyranose
-
-
-
?
Man8GlcNAc + 3 H2O
Man5GlcNAc + 3 alpha-D-mannopyranose
-
-
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 alpha-D-mannopyranose
-
-
-
?
Man8GlcNAc2 + 3 H2O
Man5GlcNAc2 + 3 D-mannose
-
Golgi alpha-mannosidase in vivo
-
-
?
Man9-5GlcNAc + 4 H2O
Man5-3GlcNAc + 4 alpha-D-mannopyranose
-
different product composition for alpha-mannosidases IA, IB and II
-
?
Man9-glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
Man9GlcNAc + H2O
Manalpha(1-6)[Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAc + alpha-D-mannopyranose
-
Co2+ activated alpha-mannosidase
end products
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
Man9GlcNAc2 + H2O
Man8GlcNAc2 + mannose
-
endoplasmic reticulum alpha-mannosidase in vivo
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Man(1-6)]ManbetaGlcNac-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manbeta(1-6)]ManbetaGlcNAc-beta-GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-2)Manalpha(1-3)[Man(1-6)]ManbetaGlcNAc-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-3)GlcNAc + H2O
alpha-D-mannopyranose + N-acetyl-D-glucosamine
-
-
-
?
Manalpha(1-3)[Man(1-6)]ManbetaGlcNAc-betaGlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Manalpha(1-4)Manbeta(1-4)Man + H2O
alpha-D-mannopyranose + Manbeta(1-4)Man
-
-
-
?
Manalpha(1-6)GlcNAc + H2O
alpha-mannopyranose + N-acetyl-D-glucosamine
-
-
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-)]Manbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
4 times faster hydrolysis than Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
mannan + H2O
alpha-D-mannose + ?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
mannosyl rhamnose + H2O
alpha-D-mannopyranose + rhamnose
-
part of the repeating oligosaccharide unit of the O-antigenic lipopolysaccharide in Salmonella typhimurium
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
mannotriose + H2O
alpha-D-mannopyranose + mannobiose
-
-
-
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
thyroglobulin + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
additional information
?
-
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
highly specific for alpha-1,2-mannosidic linkages
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
-
-
-
?
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 D-mannopyranose
-
-
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
3-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
2 alpha-D-mannopyranose
-
very low activity
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
-
very low activity
-
?
6-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O
alpha-D-mannopyranose
-
specific cleavage of alpha-1,4- or alpha-1,6-linkages
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
-
-
?
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
-
end products
?
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
beta-glucuronidase peptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
-
-
-
?
GDP-mannosylpyranose + H2O
alpha-D-mannopyranose + GDP
-
-
-
?
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
GlcNAcMan5GlcNAc + H2O
alpha-D-mannopyranose + ?
-
low activity
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
faster hydrolysis than for glycoprotein
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
contains only alpha-1,2-linked mannose residues, highly specific on alpha-1,2-linked mannooligosaccharides
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
-
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
stem bromelain
-
?
glycopeptide + H2O
alpha-D-mannopyranose + ?
-
from ovalbumin
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
-
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
ovomucoid, orosomucoid, ovalbumin
-
?
glycoprotein + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
-
-
-
?
Man6GlcNAc + H2O
alpha-D-mannopyranose + ?
-
ordered hydrolysis of alpha(1-2)-residues followed by hydrolysis of alpha(1-3)- and alpha(1-6)-linked residues
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
-
-
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
-
end product for Tris-eluted isoform, representing the Man5-oligosaccharide chain of the dolichol pathway formed in the cytosolic compartment during biosynthesis of N-glycosylprotein glycans
?
Man9GlcNAc + 4 H2O
Man5GlcNAc + 4 alpha-D-mannopyranose
-
hydrolyses alpha-1,2- and alpha-1,3-linkages
after 24 h incubation, specifically removes alpha-1,2-linked mannoses
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
-
involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages
major product: Man6GlcNAc2
?
Man9GlcNAc2 + H2O
Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose
-
-
major product: Man5GlcNAc2, involved in Asn-linked oligosaccharide maturation
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
only mannose librated
?
mannan + H2O
alpha-D-mannose + ?
-
from baker's and sake yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
specific for alpha-1,2-linked mannopyranosyl residues
-
?
mannan + H2O
alpha-D-mannose + ?
-
derived from wild type or mutant strains of Saccharomyces cerevisiae, different specific activities for isoforms EI and EII, depending on the type of alpha-D-linkages of mutant substrates, preference for cleavage of alpha-1,6- and alpha-1,3-linkages
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
yeast alpha-mannan, main product: alpha-D-mannose, hydrolysis of linear and branched mannans containing terminal alpha-1,2- and alpha-1,3-linked mannopyranosyl residues
-
?
mannan + H2O
alpha-D-mannose + ?
-
very low activity
-
?
mannan + H2O
alpha-D-mannose + ?
-
very low activity
-
?
mannan + H2O
alpha-D-mannose + ?
-
from yeast
-
?
mannan + H2O
alpha-D-mannose + ?
-
from baker's and sake yeast
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
reverse action on alpha-D-mannopyranose, 85%, w/w, yields 0.93 M disaccharide with 4 different isomers, 0.61 M trisaccharide, 0.25 M tetrasaccharide and higher oligosaccharides, retention of anomeric configuration
-
r
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, hydrolysis of alpha-1,2- and alpha-1,3-linkages
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, hydrolysis of alpha-1,2- and alpha-1,3-linkages
-
?
mannopyranosyl-oligosaccharides + H2O
alpha-D-mannopyranose + ?
-
from yeast mannan, a tetrasaccharide terminating in a mannopyranosyl residue linked to C-3 of its neighbour is not hydrolysed
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
-
-
-
?
mannotetraose + H2O
alpha-D-mannopyranose + mannotriose
-
-
-
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
-
from bovine pancreas
single oligosaccharide component
?
ribonuclease B + H2O
oligosaccharide + alpha-D-mannopyranose + ?
-
-
-
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
from Aspergillus oryzae, hydrolysis of a single Man-1,2-linkage
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
TAKA-amylase A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
thyroglobulin peptide A + H2O
alpha-D-mannopyranose + ?
-
-
-
?
additional information
?
-
-
the enzyme is involved in ordered degradation of glycoproteins, inborn enzyme-deficiency results in lysosomal storage disorder alpha-mannosidosis
-
-
?
additional information
?
-
Drosophila sp. (in: flies)
-
key enzyme in N-glycan processing
-
-
?
additional information
?
-
-
anomalies of the enzyme system detected in patients with amyotrophic lateral sclerosis could reflect a situation of progressive injury of proteins
-
-
?
additional information
?
-
-
the enzyme is required in the degradation of the asparagine-linked carbohydrates of glycoproteins. Deficiency of this enzyme leads to the lysosomal storage disorder alpha-mannosidosis
-
-
?
additional information
?
-
-
class 1 alpha1,2-mannosidases of glycosylhydrolase family 47 play critical roles in the maturation of Asn-linked glycoproteins in the endoplasmic reticulum and Golgi complex as well as in the recognition and timing of disposal of terminally unfolded proteins by ER-associated degradation, overview
-
-
?
additional information
?
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
the enzyme could be putatively involved in the turnover and/or the maturation of glycoprotein
-
-
?
additional information
?
-
higher eukaryotic GH38 alpha-mannosides play a key role in the modification and diversification of hybrid N-glycans, processes with strong cellular links to cancer and autoimmune disease
-
-
?
additional information
?
-
-
the exo-type cytosolic class II enzyme cleaves off alpha-1,2-, alpha-1,3-, and alpha-1,6-mannose residues
-
-
?
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(1R,6R,7R,8S)-7,8-dihydroxy-5-thia-1-thioniabicyclo[4.3.0]nonane chloride
-
synthetic inhibitor, selective and potent inhibition at 1 mM, 97% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 100% at pH 6.5
(1S,2R,3R,8R,8aR)-3-[(arylmethoxy)methyl]octahydroindolizine-1,2,8-triol
-
-
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol
(2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol
(2R,3R,4S)-2-([(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl)pyrrolidine-3,4-diol
-
IC50 is 0.017 mM
(2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
(2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
(2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
(2R,3R,4S)-2-hydroxymethyl-pyrrolidine-3,4-diol
(2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol
(2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol
(2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol
-
IC50 is 0.06 mM
(2R,3R,4S)-2-[(cyclopentylamino)methyl]pyrrolidine-3,4-diol
(2R,3R,4S)-2-[([(1R)-2-benzyloxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
92% inhibition at 1 mM, IC50 is 0.058 mM
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
(2R,3R,4S)-2-[([(1R)-2-methoxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
77% inhibition at 1 mM
(2R,3R,4S)-2-[([(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
88% inhibition at 1 mM, IC50 is 0.11 mM
(2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
(2R,3R,4S)-2-[([(1S,2R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
84% inhibition at 1 mM, IC50 is 0.128 mM
(2R,3R,4S)-2-[2-(phenylamino)ethyl]pyrrolidine-3,4-diol
-
1 mM, 33% inhibition
(2R,3R,4S)-2-[[(1-benzyl-piperidin-4-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
(2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
(2R,3R,4S)-2-[[(furan-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
(2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
(2R,3R,4S,5R)-2-[(benzylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol
-
IC50 is 0.0062 mM
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[([(1R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
98% inhibition at 1 mM, IC50 is 0.0042 mM
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 3-bromobenzoate
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-bromobenzoate
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one
(3S,4R)-pyrrolidine-3,4-diol
(6-butoxy-3-oxo-3,6-dihydro-2H-pyran-2-yl)methyl 2,2-dimethylpropanoate
-
-
(6-methoxy-3-oxo-3,6-dihydro-2H-pyran-2-yl)methyl 2,2-dimethylpropanoate
-
-
1,4-Dideoxy-1,4-imino-D-mannitol
-
1,6-dideoxy-1,6-episulfinyl-beta-D-mannose
-
XLM, sulfoxide derivative, thiolevomannosan analog, more potent than kifunensine and deoxymannojirimycin, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template
1,6-dideoxy-1,6-episulfonyl-beta-D-mannose
-
NLM, sulfone derivative, thiolevomannosan analog, more potent than kifunensine and deoxymannojirimycin, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template
1,6-dideoxy-1,6-epithio-beta-D-mannose
-
thiolevomannosan TLM, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template
1-cyclohexyl-3-(2-morpholinyl-4-ethyl)carbodiimide
-
inhibitory at 25 mM, pseudo-first-order kinetic
1-deoxy-mannojirimycin
-
complete inhibition
2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol
2-amino-2-deoxy-D-glucose
-
competitive inhibition, Ki = 2.8 mM
2-deoxy-2-fluoro-alpha-D-mannosyl fluoride
-
for mutant enzyme D341N, no inhibition of wild-type enzyme
3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide
5-fluoro-beta-L-gulosyl fluoride
-
reversible, acts as a slow substrate for the D341 mutant enzyme, with deglycosylation as the rate-limiting step. Inactivation is only observed when assayed at low temperatures such that deglycosylation is slow relative to the assay time
8,8a-di-epi-swainsonine
-
-
alpha-conglutin
-
11% inhibition at saturation
-
alpha-D-1,2-mannopyranosyl-mannopyranose
-
50% inhibition at 4 mM
alpha-D-1,3-mannopyranosyl-alpha-D-mannopyranose
-
50% inhibition at 18 mM
alpha-D-1,6-mannopyranosyl-mannopyranose
-
50% inhibition at 100 mM
cysteine
-
31% inhibition at 0.02 mM
D-glucose
-
67% inhibition at 30 mM
D-glucuronic acid
-
slight inhibition at 10 mM
D-mannono-gamma-lactone
-
-
diisopropylfluorophosphate
-
42% inhibition at 10 mM
EGTA
-
32% inhibition at 5 mM
gluco-hydroxyiminolactam
-
-
iodoacetamide
-
slight inhibition at 1 mM
Li+
-
88% inhibition at 20 mM
Mannan
-
33% inhibition at 50 mM
mannose
-
relative inhibition of 67.8%, potent inhibitor, three concentrations of 10, 50, and 100 mM tested
methyl-alpha-D-glucoside
-
23% inhibition at 10 mM
methyl-alpha-D-lyxopyranosyl-(1'-2)-alpha-D-mannopyranoside
-
-
methyl-alpha-D-lyxopyranosyl-(1-2)-alpha-D-mannopyranoside
-
potent
methyl-alpha-D-mannopyranoside
methyl-alpha-mannoside
-
not
N-bromosuccinimide
-
N-bromosuccinimide modified inactivation, effect of Trp modification on enzyme activity
N-octyl-6-epi-valienamine
-
-
Na+
-
1 mM, weak, not at 10 mM
NaN3
-
slight inhibition at 0.1 mM
p-chloromercuribenzenesulfonic acid
p-nitrophenyl-alpha-D-mannopyranoside
-
substrate inhibition greater than 2 mM
SDS
-
85% inhibition at 0.05%, w/v
small interfering RNA
siRNA designed to specifically inhibit Man2C1 gene expression, alpha-mannosidase activity is compromised in siRNA-treated cells. Determination of alteration of siRNA treatment, glycans recovered from membrane glycoproteins are fluorescence-labelled and analysed by HPLC
-
Sr2+
-
inhibition at 1 mM
ZnCl2
-
92% inhibition by 1 mM, 56% inhibition by 0.01 mM
[6-(3-methylbutoxy)-3-oxo-3,6-dihydro-2H-pyran-2-yl]acetonitrile
-
-
[6-(3-methylbutoxy)-3-oxo-3,6-dihydro-2H-pyran-2-yl]methyl 2,2-dimethylpropanoate
-
-
[[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate
-
-
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol
-
-
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol
-
-
(2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol
-
1 mM, 81% inhibition, competitive
(2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol
-
1 mM, 51% inhibition
(2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
-
1 mM, 75% inhibition, competitive
(2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
-
1 mM, 39% inhibition
(2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
-
-
(2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
-
-
(2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
-
1 mM, 66% inhibition, competitive
(2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol
-
1 mM, 45% inhibition
(2R,3R,4S)-2-hydroxymethyl-pyrrolidine-3,4-diol
-
1 mM, 54% inhibition
(2R,3R,4S)-2-hydroxymethyl-pyrrolidine-3,4-diol
-
1 mM, 37% inhibition
(2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol
-
1 mM, 92% inhibition, competitive
(2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol
-
1 mM, 69% inhibition, competitive
(2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol
-
1 mM, 66% inhibition, competitive
(2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol
-
1 mM, 48% inhibition
(2R,3R,4S)-2-[(cyclopentylamino)methyl]pyrrolidine-3,4-diol
-
1 mM, 60% inhibition
(2R,3R,4S)-2-[(cyclopentylamino)methyl]pyrrolidine-3,4-diol
-
1 mM, 53% inhibition
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
complete and selective inhibition at 1 mM, IC50 is 700 nM
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
potent and selective inhibition
(2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
92% inhibition at 1 mM, IC50 is 0.1 mM
(2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol
-
-
(2R,3R,4S)-2-[[(1-benzyl-piperidin-4-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 55% inhibition
(2R,3R,4S)-2-[[(1-benzyl-piperidin-4-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 59% inhibition
(2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 55% inhibition
(2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 59% inhibition
(2R,3R,4S)-2-[[(furan-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 49% inhibition
(2R,3R,4S)-2-[[(furan-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 29% inhibition
(2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 89% inhibition, competitive
(2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol
-
1 mM, 68% inhibition, competitive
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate
-
83% inhibition at 1 mM, IC50 is 0.063 mM
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate
-
-
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 3-bromobenzoate
-
79% inhibition at 1 mM
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 3-bromobenzoate
-
-
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-bromobenzoate
-
92% inhibition at 1 mM
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-bromobenzoate
-
-
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate
-
92% inhibition at 1 mM, IC50 is 0.060 mM
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate
-
-
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one
-
-
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one
-
-
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one
-
-
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one
-
-
(3S,4R)-pyrrolidine-3,4-diol
-
1 mM, 70% inhibition
(3S,4R)-pyrrolidine-3,4-diol
-
1 mM, 40% inhibition
1-deoxymannojirimicin
-
hydrolysis of 4-methylumbelliferyl-alpha-D-mannnopyranoside, strong inhibition for enzymes I and II at 0.025 mM
1-deoxymannojirimicin
-
67% inhibition at 1 mM when 4-methylumbelliferyl-alpha-D-mannopyranoside is used, 15% inhibition when p-nitrophenyl-alpha-D-mannopyranoside is used as substrates
1-deoxymannojirimicin
-
19% inhibition at 0.01 mM
1-deoxymannojirimicin
-
complete inhibition at 1 mM
1-deoxymannojirimicin
-
IC50 = 0.01 mM
1-deoxymannojirimicin
-
50% inhibition at 0.05 mM
1-deoxymannojirimycin
-
binding of swainsonine to the enzyme is stronger than bionding of 1-deoxymannojirimycin; competitive inhibitor, low binding up to 40°C, increased binding at 50°C
1-deoxymannojirimycin
-
61% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 37% at pH 6.5, at 1 mM
1-deoxymannojirimycin
-
class 1 alpha1,2-mannosidase inhibitor
1-deoxymannojirimycin
-
pretreatment with 1-deoxymannojirimycin protectes primary cultured mouse cortical neurons from Amyloid beta1-42 toxicity
1-deoxymannojirimycin
-
mannose analog, in vivo and in vitro; reversible (not by Ca2+)
1-deoxymannojirimycin
-
pretreatment with 100 mM inhibitor 1-deoxymannojirimycin in PC-12 cells significantly attenuates the cytotoxicity by endoplasmic reticulum stressors tunicamycin, thapsigargin, and amyloid bbeta1-42, and reduces caspase-3 activation by tunicamycin and thapsigarin
1-deoxymannojirimycin
-
-
1-deoxymannojirimycin
-
-
2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol
-
1 mM, 81% inhibition, mixed type
2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol
-
1 mM, 56% inhibition
3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide
-
95% inhibition at 1 mM, IC50 is 0.089 mM
3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide
-
-
Ag+
-
-
Ag+
-
52% inhibition at 10 mM
Ag+
-
slight inhibition at 1 mM for isoforms I, II
Ag+
-
97% inhibition at 10 mM
Ag+
strong inhibitor at concentrations of 1 mM or 10 mM
Ag+
-
70% inhibition at 1 mM
Ag+
-
moderate inhibition at 1 mM
alpha-D-mannopyranose
-
55% inhibition at 30 mM
alpha-D-mannopyranose
-
competitive inhibition, Ki: 22 mM
alpha-D-mannopyranose
-
29% inhibition at 10 mM
alpha-D-mannopyranose
-
27% inhibition at 10 mM
alpha-D-mannopyranose
-
competitive inhibition, Ki: 85 mM
alpha-D-mannopyranose
-
30% inhibition at 250 mM
alpha-D-mannopyranose
-
competitive inhibition, Ki: 20 mM
alpha-D-mannopyranose
-
50% inhibition at 250 mM
Ba2+
-
inhibition at 1 mM
Ba2+
-
10 mM; 78% inhibition at 10 mM
Ca2+
-
inhibition at 0.1 mM
Ca2+
-
inhibitory for enzyme I above 5 mM, enzyme II not affected
Ca2+
-
53% inhibition at 0.1 mM
Ca2+
-
slight inhibition at 1 mM
Cd2+
-
inhibition at 0.1 mM
Cd2+
-
10 mM, activation at 1 mM; 54% inhibition at 10 mM, slight stimulation at 1 mM
Co2+
-
51% inhibition at 10 mM
Co2+
-
slight inhibition at 10 mM
Co2+
-
46% inhibition at 1 mM
Co2+
-
10-30% inhibition for acid alpha-mannosidase
Co2+
-
slight inhibition at 1 mM
Co2+
-
inhibition of alpha-mannosidases IA and IB
Co2+
-
57% inhibition at 1 mM
Cu2+
-
87% inhibition at 20 mM
Cu2+
-
inhibition at 0.1 mM
Cu2+
-
10 mM; 41% inhibition at 10 mM
Cu2+
-
slight inhibition at 10 mM
Cu2+
-
complete inhibition at 1 mM
Cu2+
-
slight inhibition at 0.1 mM
Cu2+
-
nearly complete inhibition at 0.005 mM
Cu2+
-
complete inhibition at 0.1 mM
Cu2+
-
complete inhibition of the Co2+ activated enzyme at 0.5 mM
Cu2+
-
complete inhibition at 1 mM
Cu2+
-
10% inhibition at 10 mM, alpha-mannosidase A
Cu2+
strong inhibitor at concentrations of 1 mM or 10 mM
Cu2+
-
strong inhibition at 1 mM
Cu2+
-
inhibition of alpha-mannosidases IA, IB and II
Cu2+
-
strong inhibition at 1 mM
Cu2+
inhibits in presence of Co2+
Cu2+
-
nearly complete inhibition at 0.01 mM
D-mannono-1,4-lactone
-
36% inhibition at 10 mM
D-mannono-1,4-lactone
-
competitive inhibition, Ki: 13 mM
D-mannono-1,4-lactone
-
11% inhibition at 10 mM
D-mannono-1,4-lactone
-
Ki: 23.8 mM
D-mannono-1,5-lactone
-
complete inhibition at 1 mM
D-mannono-1,5-lactone
-
weak inhibition
D-mannono-1,5-lactone
-
50% competitive inhibition at 0.073 mM
D-mannosylamine
-
15% competitive inhibition at 5 mM
D-mannosylamine
-
56% inhibition at 1 mM
D-mannosylamine
-
competitive inhibition, Ki = 0.007 mM
deoxymannojirimycin
-
-
deoxymannojirimycin
Drosophila sp. (in: flies)
-
-
deoxymannojirimycin
less effective compared with swainsonine, concentration of 100 microM
deoxymannojirimycin
-
DMJ 3
EDTA
-
slight inhibition at 1 mM
EDTA
-
slight inhibition at 1 mM
EDTA
-
addition of Zn2+ restores inhibitory effect; strong inhibition at 1 mM
EDTA
-
37% inhibition at 5 mM
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
complete inhibition at 1 mM, addition of 1 mM Zn2+ fully restores activity for isoforms II, to 69% for isoforms I
EDTA
-
complete inhibition at 20 mM, activity recovered in the presence of Ca2+
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
complete inhibition at 0.05 mM
EDTA
supplied in equimolar amounts or in excess, neutralizes also effect of resistance of ManA to heat inactivation
EDTA
-
strong inhibition at 1 mM
EDTA
-
inhibitory for alpha-mannosidases IA and IB
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
strong inhibition at 1 mM
EDTA
-
1 mM, more than 90% inactivation
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
addition of Zn2+ restores inhibitory effect
EDTA
-
60-75% inhibition at 4 mM, activity restored by addition of Ca2+
EDTA
-
complete inactivition, Zn2+ restores, Ca2+, Cd2+, Mg2+, Ni2+, Na+ or Cu2+ restore partly
Fe2+
-
22% inhibition at 20 mM
Fe2+
-
58% inhibition at 10 mM
Fe2+
-
slight inhibition at 10 mM
Fe2+
-
54% inhibition at 1 mM
Fe2+
-
complete inhibition at 1 mM
Fe2+
-
slight inhibition at 1 mM
Fe2+
-
nearly complete inhibition at 1 mM
Fe3+
-
inhibition at 1 mM
Fe3+
-
43% inhibition at 1 mM
Fe3+
strong inhibitor at concentrations of 1 mM or 10 mM
Hg2+
-
strong inhibitor
Hg2+
-
complete inhibition at 10 mM
Hg2+
-
complete inhibition at 1 mM
Hg2+
-
slight inhibition at 1 mM for isoforms I,II
Hg2+
-
45% inhibition at 10 mM
Hg2+
-
complete inhibition at 1 mM
iodoacetic acid
-
-
iodoacetic acid
-
slight inhibition at 1 mM
iodoacetic acid
-
slight inhibition at 0.1 mM
kifunensine
-
-
kifunensine
little inhibitory effect, concentration of 10 microM
kifunensine
-
Kif 2, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template
kifunensine
-
class 1 alpha1,2-mannosidase inhibitor
methyl-alpha-D-mannopyranoside
-
20% inhibition at 10 mM
methyl-alpha-D-mannopyranoside
-
40-50% inhibition of acid alpha-mannosidase, neutral alpha-mannosidase not affected
methyl-alpha-D-mannopyranoside
-
41% inhibition at 10 mM
methyl-alpha-D-mannopyranoside
-
slight inhibitory for alpha-mannosidases IA and IB
methyl-alpha-D-mannopyranoside
-
37% inhibition at 0.1 mM
Mg2+
-
61% inhibition at 20 mM
Mg2+
-
inhibition at 1 mM
Mg2+
-
slight inhibition at 1 mM
Mn2+
-
inhibition at 1 mM
Mn2+
-
slight inhibition at 1 mM
Mn2+
-
slight inhibition at 1 mM
Mn2+
-
inhibitory for enzyme I above 5 mM, slightly inhibitory for enzyme II
Mn2+
-
58% inhibition at 0.1 mM
Mn2+
-
complete inhibition at 1 mM
Mn2+
-
slight inhibition at 1 mM
Mn2+
-
slight inhibition at 1 mM
Ni2+
strong inhibitor at concentrations of 1 mM or 10 mM
Ni2+
-
moderate inhibition at 1 mM
Ni2+
inhibits in presence of Co2+
p-chloromercuribenzenesulfonic acid
-
strong inhibition at 1 mM
p-chloromercuribenzenesulfonic acid
-
different inhibition rates for alpha-mannosidases IA, IB and II
p-chloromercuribenzenesulfonic acid
-
strong inhibition at 1 mM
p-chloromercuribenzenesulfonic acid
-
complete inhibition at 1 mM
p-chloromercuribenzenesulfonic acid
-
50% inhibition at 0.35 mM, activity is restored by addition of substrate
Pb2+
-
complete inhibition of the Co2+ activated enzyme at 0.5 mM
Pb2+
-
moderate inhibition at 1 mM
swainsonine
-
binding of swainsonine to the enzyme is stronger than bionding of 1-deoxymannojirimycin; competitive inhibitor, low binding up to 40°C, increased binding at 50°C
swainsonine
-
IC50 is 400 nM
swainsonine
-
hydrolysis of 4-umbelliferyl-alpha-D-mannopyranoside, strong inhibition for enzymes I and II at 0.025 mM
swainsonine
-
83% inhibition at 0.3 mM if 4-methylumbelliferyl-alpha-D-mannopyranoside is used, hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside only slightly diminished at 0.3 mM
swainsonine
-
swainsonine treatment completely inhibits the acid enzyme form activity below pH 5.0
swainsonine
-
complete inhibition of the Co2+ activated enzyme at 0.01 mM
swainsonine
-
IC50: 0.00011 mM
swainsonine
-
potent inhibition at 1 mM, 100% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 95% at pH 6.5
swainsonine
-
20% inhibition of glioblastoma cell growth at 0.25 mM
swainsonine
concentration of 100 microM
swainsonine
IC50: 0.00015 mM
swainsonine
shows competitive inhibition when p-nitrophenyl-Man is used as a substrate
swainsonine
-
competitive inhibition, Ki: 0.00036 mM
swainsonine
-
inhibition of both Tris-eluted and unbound isoforms from cobalt-chelating Sepharose, unbound: Ki: 0.028 mM, Tris-eluted: Ki: 0.004 mM
swainsonine
-
50% inhibition in the range of 0.3-0.6 mM
swainsonine
the enzyme substituted with Zn2+ is considerably less sensitive to swainsonine compared with the Co2+-, Cd2+-, and Mn2+-substituted enzyme
swainsonine
-
complete inhibition
swainsonine
-
IC50: 10 nM
swainsonine
binding structure, overview
swainsonine
-
competitive
swainsonine
-
competitive inhibition
swainsonine
-
50% inhibition at 0.00024 mM
swainsonine
-
complete inhibition at 0.008 mM
swainsonine
-
complete inhibition
Tris
-
in vivo and in vitro
Tris
-
inhibitory for alpha-mannosidases IA and IB
Zn2+
-
25% inhibition at 20 mM
Zn2+
-
inhibition at 1 mM
Zn2+
-
55% inhibition at 10 mM
Zn2+
-
complete inhibition of the Co2+ activated enzyme at 0.5 mM
Zn2+
-
complete inhibition at 1 mM
Zn2+
-
reversible by Ca2+
Zn2+
-
strong inhibition at 1 mM
Zn2+
-
slight inhibition for alpha-mannosidase IA
Zn2+
-
moderate inhibition at 1 mM
Zn2+
mutant enzymes H228Q, H533E, and H533Q, are all inhibited by high Zn2+ concentrations (1 mM)
additional information
-
no inhibition by L-cysteine
-
additional information
-
no inhibition by (2R,3R,4S)-2-[(2-hydroxy-1-methyl-2,2-diphenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol, and (2R,3R,4S)-2-(1,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol
-
additional information
-
not inhibitory: 1,5-D-mannoseptanosyl di- and trisaccharide ring-size isomers
-
additional information
-
inhibition of growth of glioblastoma and melanoma cells by pyrrolidine-3,4-diol derivatives, overview
-
additional information
down-regulation of Man2C1 activity by a small interfering RNA drastically change amount and structure of oligosaccharides accumulating in the cytosol, demonstrating that Man2C1 is involved in free oligosaccharide processing in the cytosol
-
additional information
-
down-regulation of Man2C1 activity by a small interfering RNA drastically change amount and structure of oligosaccharides accumulating in the cytosol, demonstrating that Man2C1 is involved in free oligosaccharide processing in the cytosol
-
additional information
-
inhibitory activity of thiosugar derivatives (thiolevomannosans) is tested against alpha-mannosidase
-
additional information
-
no inhibition by Mg2+
-
additional information
1-deoxymannojirimycin has no effect on ManA at concentrations up to 500 microM
-
additional information
-
1-deoxymannojirimycin has no effect on ManA at concentrations up to 500 microM
-
additional information
-
no inhibition by (2R,3R,4S)-2-[(2-hydroxy-1-methyl-2,2-diphenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol, (2R,3R,4S)-2-(1,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol, and (2R,3R,4S)-2-[2-(phenylamino)ethyl]pyrrolidine-3,4-diol
-
additional information
activity is insensitive to 1-deoxymannojirimycin at concentration up to 2 mM. No change in the enzymatic activity is observed with 0.001-1 mM EDTA
-
additional information
-
activity is insensitive to 1-deoxymannojirimycin at concentration up to 2 mM. No change in the enzymatic activity is observed with 0.001-1 mM EDTA
-
additional information
-
no inhibition by 1-deoxymannojirimycin
-
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5
2,4-dinitrophenyl alpha-D-mannoside
-
wild-type enzyme
25
2,4-dinitrophenyl-alpha-D-mannopyranoside
-
pH 5.0, 50°C
0.57 - 2
2-O-alpha-D-mannopyranosyl-D-mannopyranose
0.57
2-O-alpha-D-Mannopyranosyl-D-mannose
-
37°C, pH 5.3
27
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose
pH 6.8, 37°C, recombinant enzyme
0.00731 - 3.6
4-methylumbelliferyl alpha-D-mannopyranoside
0.0073 - 5.2
4-methylumbelliferyl-alpha-D-mannopyranoside
1.48 - 3.8
4-nitrophenyl alpha-D-mannopyranoside
0.11 - 2.9
4-nitrophenyl alpha-D-mannoside
0.0826 - 1.8
4-nitrophenyl-alpha-D-mannopyranoside
1.6
4-nitrophenyl-alpha-D-mannoside
-
pH 6.0, 37°C
0.2
5-fluoro-beta-L-gulosyl fluoride
-
wild-type enzyme
0.85 - 2.3
alpha-D-Man-(1->2)-D-Man
1.16
alpha-D-Man-(1->3)-D-Man
pH 5.0, 70°C, enzyme in complex with Co2+
2 - 2.5
alpha-D-Man-(1->4)-D-Man
2
alpha-D-Man-(1->6)-D-Man
pH 5.0, 70°C, enzyme in complex with Co2+
0.839
Man-alpha(1-3)Man
-
pH 6.5, 50°C, 20 min
1.116
Manalpha(1-2)Man
-
pH 6.5, 50°C
0.839
Manalpha(1-3)Man
-
pH 6.5, 50°C
0.44
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-)]Manbeta(1-4)GlcNAc
-
-
0.6
methyl-2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside
-
37°C, pH 6.0
8.2
methyl-4-O-alpha-D-mannopyranosyl-D-mannopyranoside
-
-
0.34
methyl-alpha-D-mannopyranoside
-
-
0.048 - 30
p-nitrophenyl-alpha-D-mannopyranoside
1.04
p-nitrophenyl-alpha-D-mannoside
-
-
0.42
phenyl-alpha-D-mannopyranoside
-
-
additional information
Mannan
0.57
2-O-alpha-D-mannopyranosyl-D-mannopyranose
-
-
2
2-O-alpha-D-mannopyranosyl-D-mannopyranose
-
-
0.00731
4-methylumbelliferyl alpha-D-mannopyranoside
-
pH 6.5, 50°C, 15 min, reaction stopped with Na2CO3
0.95
4-methylumbelliferyl alpha-D-mannopyranoside
-
at pH 5.0 and 37°C
3.6
4-methylumbelliferyl alpha-D-mannopyranoside
pH 6.8, 37°C, recombinant enzyme
0.0073
4-methylumbelliferyl-alpha-D-mannopyranoside
-
pH 6.5, 50°C
0.1
4-methylumbelliferyl-alpha-D-mannopyranoside
-
-
0.14
4-methylumbelliferyl-alpha-D-mannopyranoside
-
-
0.55
4-methylumbelliferyl-alpha-D-mannopyranoside
-
pH 5.0, 37°C, HCEC cell layer
0.65
4-methylumbelliferyl-alpha-D-mannopyranoside
-
pH 5.0, 37°C, LNZ-308 cell layer
1.065
4-methylumbelliferyl-alpha-D-mannopyranoside
-
pH 5.0, 37°C, LN-18 cell layer
1.8
4-methylumbelliferyl-alpha-D-mannopyranoside
-
-
2.2
4-methylumbelliferyl-alpha-D-mannopyranoside
-
-
5.2
4-methylumbelliferyl-alpha-D-mannopyranoside
-
-
1.48
4-nitrophenyl alpha-D-mannopyranoside
-
pH 5.0, 37°C
3.8
4-nitrophenyl alpha-D-mannopyranoside
-
-
0.11
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, enzyme in complex with Co2+
0.13
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Co2+, mutant enzyme H533Q
0.35
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Co2+, wild-type enzyme
0.39
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, enzyme in complex with Mn2+
0.4
4-nitrophenyl alpha-D-mannoside
pH 6.5, 65°C, recombinant enzyme
0.45
4-nitrophenyl alpha-D-mannoside
pH 6.5, 65°C, native enzyme
0.47
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Mn2+, wild-type enzyme
0.65
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, enzyme in complex with Zn2+
0.7
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Mn2+, mutant enzyme H533Q
0.74
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Zn2+, wild-type enzyme
0.99
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, enzyme in complex with Cd2+
1
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, untreated enzyme which with no externally added metal ion in the incubation assay
1.1
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 0.1 mM Zn2+, mutant enzyme H533Q
1.1
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Cd2+, mutant enzyme H533Q
1.1
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Zn2+, mutant enzyme H228E
1.4
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Co2+, mutant enzyme H228E
1.7
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Co2+, mutant enzyme H228Q
1.9
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Cd2+, wild-type enzyme
1.9
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Zn2+, mutant enzyme H533Q
2.5
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Zn2+, mutant enzyme H228Q
2.7
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Cd2+, mutant enzyme H228E
2.9
4-nitrophenyl alpha-D-mannoside
pH 5.0, 70°C, 1 mM Co2+, mutant enzyme H533E
0.0826
4-nitrophenyl-alpha-D-mannopyranoside
-
pH 6.5, 50°C
0.08265
4-nitrophenyl-alpha-D-mannopyranoside
-
-
1.8
4-nitrophenyl-alpha-D-mannopyranoside
-
pH 5.0
0.85
alpha-D-Man-(1->2)-D-Man
pH 5.0, 70°C, enzyme in complex with Co2+
2.3
alpha-D-Man-(1->2)-D-Man
pH 5.0, 70°C, enzyme in complex with Mn2+
2
alpha-D-Man-(1->4)-D-Man
pH 5.0, 70°C, enzyme in complex with Mn2+
2.5
alpha-D-Man-(1->4)-D-Man
pH 5.0, 70°C, enzyme in complex with Co2+
1.455
Man-alpha(1-6)Man
-
pH 6.5, 50°C
1.455
Man-alpha(1-6)Man
-
pH 6.5, 50°C, 20 min
0.037
Man9GlcNAc
-
pH 7.0, 37°C, Co2+-treated enzyme
0.46
Man9GlcNAc
-
pH 7.0, 37°C, not treated with Co(II)
0.048
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.05
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.072
p-nitrophenyl-alpha-D-mannopyranoside
-
Tris-eluted isoform from cobalt-chelating Sepharose
0.083
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.14
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.17
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.23
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.27
p-nitrophenyl-alpha-D-mannopyranoside
-
-
0.63
p-nitrophenyl-alpha-D-mannopyranoside
-
unbound isoform from cobalt-chelating Sepharose
0.91
p-nitrophenyl-alpha-D-mannopyranoside
-
-
1
p-nitrophenyl-alpha-D-mannopyranoside
-
-
1.2
p-nitrophenyl-alpha-D-mannopyranoside
-
-
1.4
p-nitrophenyl-alpha-D-mannopyranoside
-
-
1.8
p-nitrophenyl-alpha-D-mannopyranoside
-
alpha-mannosidase I
1.86
p-nitrophenyl-alpha-D-mannopyranoside
-
enzyme II
1.92
p-nitrophenyl-alpha-D-mannopyranoside
-
alpha-mannosidase A
2
p-nitrophenyl-alpha-D-mannopyranoside
-
alpha-mannosidase II
2
p-nitrophenyl-alpha-D-mannopyranoside
-
fairly constant between pH 4.5-6.0
2.04
p-nitrophenyl-alpha-D-mannopyranoside
-
enzyme I
2.3
p-nitrophenyl-alpha-D-mannopyranoside
-
-
2.3
p-nitrophenyl-alpha-D-mannopyranoside
-
-
2.3
p-nitrophenyl-alpha-D-mannopyranoside
-
-
2.4
p-nitrophenyl-alpha-D-mannopyranoside
-
-
2.7
p-nitrophenyl-alpha-D-mannopyranoside
-
alpha-mannosidase B
2.7
p-nitrophenyl-alpha-D-mannopyranoside
-
isoforms II
2.8
p-nitrophenyl-alpha-D-mannopyranoside
-
-
3.3
p-nitrophenyl-alpha-D-mannopyranoside
-
-
3.7
p-nitrophenyl-alpha-D-mannopyranoside
-
isoforms I
4.3
p-nitrophenyl-alpha-D-mannopyranoside
-
-
6.5
p-nitrophenyl-alpha-D-mannopyranoside
-
at pH 7.0
10
p-nitrophenyl-alpha-D-mannopyranoside
-
-
10.7
p-nitrophenyl-alpha-D-mannopyranoside
-
-
10.9
p-nitrophenyl-alpha-D-mannopyranoside
-
at pH 3.5
12.6
p-nitrophenyl-alpha-D-mannopyranoside
-
30
p-nitrophenyl-alpha-D-mannopyranoside
-
-
additional information
Mannan
-
value in mg/ml
additional information
additional information
-
-
-
additional information
additional information
-
the KM-value for 2-deoxy-2-fluoro-alpha-D-mannosyl fluoride is above 25 mM, wild-type enzyme
-
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