EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    3.2.1.24 | 0.00001 |
- |
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol |
pH 5.0, 37°C, HCEC cell layer |
696732 |
| 3.2.1.24 | 0.00001 |
- |
swainsonine |
IC50: 10 nM |
646644 |
| 3.2.1.24 | 0.00002 |
- |
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol |
pH 5.0, 37°C, LNZ-308 cell layer |
696732 |
| 3.2.1.24 | 0.00005 |
- |
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol |
pH 5.0, 37°C, LN-18 cell layer |
696732 |
| 3.2.1.24 | 0.00011 |
- |
swainsonine |
IC50: 0.00011 mM |
135964 |
| 3.2.1.24 | 0.00015 |
- |
swainsonine |
IC50: 0.00015 mM |
135962 |
| 3.2.1.24 | 0.0004 |
- |
swainsonine |
IC50 is 400 nM |
665978 |
| 3.2.1.24 | 0.0005 |
- |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one |
pH 5.0, 37°C, HCEC cell layer |
696732 |
| 3.2.1.24 | 0.0005 |
- |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one |
pH 5.0, 37°C, LNZ-308 cell layer |
696732 |
| 3.2.1.24 | 0.0007 |
- |
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol |
complete and selective inhibition at 1 mM, IC50 is 700 nM |
665978 |
