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Literature summary for 3.2.1.24 extracted from

  • Kuntz, D.A.; Tarling, C.A.; Withers, S.G.; Rose, D.R.
    Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen (2008), Biochemistry, 47, 10058-10068.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors mannoimidazole, glucoimidazole, N-octyl-6-epi-valienamine, gluco-hydroxyiminolactam, and [[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
deoxymannojirimycin
-
Drosophila melanogaster
gluco-hydroxyiminolactam
-
Drosophila melanogaster
glucoimidazole
-
Drosophila melanogaster
kifunensine
-
Drosophila melanogaster
mannoimidazole
-
Drosophila melanogaster
N-octyl-6-epi-valienamine
-
Drosophila melanogaster
noeuromycin
-
Drosophila melanogaster
swainsonine
-
Drosophila melanogaster
[[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate
-
Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
lysosomal isoform
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,5-dinitrophenyl-alpha-D-mannopyranoside + H2O
-
Drosophila melanogaster 2,5-dinitrophenol + D-mannose
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
swainsonine pH 5.6 Drosophila melanogaster
0.02
-
mannoimidazole pH 5.6 Drosophila melanogaster
0.033
-
N-octyl-6-epi-valienamine pH 5.6 Drosophila melanogaster
0.046
-
gluco-hydroxyiminolactam pH 5.6 Drosophila melanogaster
0.07
-
glucoimidazole pH 5.6 Drosophila melanogaster
0.15
-
[[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate pH 5.6 Drosophila melanogaster