Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1S,2R,3R,8R,8aR)-3-[(arylmethoxy)methyl]octahydroindolizine-1,2,8-triol | - |
Canavalia ensiformis | |
(2R,3R,4S)-2-([(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl)pyrrolidine-3,4-diol | IC50 is 0.017 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol | IC50 is 0.06 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1R)-2-benzyloxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | 92% inhibition at 1 mM, IC50 is 0.058 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | complete and selective inhibition at 1 mM, IC50 is 700 nM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | potent and selective inhibition | Homo sapiens | |
(2R,3R,4S)-2-[([(1R)-2-methoxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | 77% inhibition at 1 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | 88% inhibition at 1 mM, IC50 is 0.11 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | 92% inhibition at 1 mM, IC50 is 0.1 mM | Canavalia ensiformis | |
(2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | - |
Homo sapiens | |
(2R,3R,4S)-2-[([(1S,2R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | 84% inhibition at 1 mM, IC50 is 0.128 mM | Canavalia ensiformis | |
(2R,3R,4S,5R)-2-[(benzylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol | IC50 is 0.0062 mM | Canavalia ensiformis | |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[([(1R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | 98% inhibition at 1 mM, IC50 is 0.0042 mM | Canavalia ensiformis | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate | 83% inhibition at 1 mM, IC50 is 0.063 mM | Canavalia ensiformis | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate | - |
Homo sapiens | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 3-bromobenzoate | 79% inhibition at 1 mM | Canavalia ensiformis | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 3-bromobenzoate | - |
Homo sapiens | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-bromobenzoate | 92% inhibition at 1 mM | Canavalia ensiformis | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-bromobenzoate | - |
Homo sapiens | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate | 92% inhibition at 1 mM, IC50 is 0.060 mM | Canavalia ensiformis | |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate | - |
Homo sapiens | |
3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide | 95% inhibition at 1 mM, IC50 is 0.089 mM | Canavalia ensiformis | |
3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide | - |
Homo sapiens | |
additional information | inhibition of growth of glioblastoma and melanoma cells by pyrrolidine-3,4-diol derivatives, overview | Homo sapiens | |
swainsonine | IC50 is 400 nM | Canavalia ensiformis | |
swainsonine | 20% inhibition of glioblastoma cell growth at 0.25 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canavalia ensiformis | - |
Jack bean | - |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Canavalia ensiformis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000135 | - |
(2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.0012 | - |
(2R,3R,4S,5R)-2-[(benzylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.00135 | - |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[([(1R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.0023 | - |
(2R,3R,4S)-2-([(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl)pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.0074 | - |
(2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.016 | - |
(2R,3R,4S)-2-[([(1R)-2-benzyloxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | 37°C | Canavalia ensiformis | |
0.019 | - |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate | 37°C | Canavalia ensiformis | |
0.024 | - |
(2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate | 37°C | Canavalia ensiformis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
IC50 is 400 nM | Canavalia ensiformis | swainsonine | |
0.0007 | - |
complete and selective inhibition at 1 mM, IC50 is 700 nM | Canavalia ensiformis | (2R,3R,4S)-2-[([(1R)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.0042 | - |
98% inhibition at 1 mM, IC50 is 0.0042 mM | Canavalia ensiformis | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[([(1R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.0062 | - |
IC50 is 0.0062 mM | Canavalia ensiformis | (2R,3R,4S,5R)-2-[(benzylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol | |
0.017 | - |
IC50 is 0.017 mM | Canavalia ensiformis | (2R,3R,4S)-2-([(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl)pyrrolidine-3,4-diol | |
0.058 | - |
92% inhibition at 1 mM, IC50 is 0.058 mM | Canavalia ensiformis | (2R,3R,4S)-2-[([(1R)-2-benzyloxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.06 | - |
92% inhibition at 1 mM, IC50 is 0.060 mM | Canavalia ensiformis | (2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 4-fluorobenzoate | |
0.06 | - |
IC50 is 0.06 mM | Canavalia ensiformis | (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol | |
0.063 | - |
83% inhibition at 1 mM, IC50 is 0.063 mM | Canavalia ensiformis | (2S)-2-[([(2R,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl 2-fluorobenzoate | |
0.089 | - |
95% inhibition at 1 mM, IC50 is 0.089 mM | Canavalia ensiformis | 3-bromo-N-[(2S)-2-[([(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl)amino]-2-phenylethyl]benzamide | |
0.1 | - |
92% inhibition at 1 mM, IC50 is 0.1 mM | Canavalia ensiformis | (2R,3R,4S)-2-[([(1S)-2-hydroxy-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.11 | - |
88% inhibition at 1 mM, IC50 is 0.11 mM | Canavalia ensiformis | (2R,3R,4S)-2-[([(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.128 | - |
84% inhibition at 1 mM, IC50 is 0.128 mM | Canavalia ensiformis | (2R,3R,4S)-2-[([(1S,2R)-2-hydroxy-1,2-diphenylethyl]amino)methyl]pyrrolidine-3,4-diol |