Literature summary for 3.2.1.24 extracted from

Sivapriya, K.; Hariharaputran, S.; Suhas, V.L.; Chandra, N.; Chandrasekaran, S.
Conformationally locked thiosugars as potent alpha-mannosidase inhibitors: synthesis, biochemical and docking studies (2007), Bioorg. Med. Chem., 15, 5659-5665.

Search for more literature for 3.2.1.24

Inhibitors

Inhibitors	Comment	Organism	Structure
1,6-dideoxy-1,6-episulfinyl-beta-D-mannose	XLM, sulfoxide derivative, thiolevomannosan analog, more potent than kifunensine and deoxymannojirimycin, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template	Homo sapiens
1,6-dideoxy-1,6-episulfonyl-beta-D-mannose	NLM, sulfone derivative, thiolevomannosan analog, more potent than kifunensine and deoxymannojirimycin, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template	Homo sapiens
1,6-dideoxy-1,6-epithio-beta-D-mannose	thiolevomannosan TLM, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template	Homo sapiens
deoxymannojirimycin	DMJ 3	Homo sapiens
kifunensine	Kif 2, docking studies with the crystal structure of human alpha-1,2-mannosidase complexed with kifunensine (PDB: 1FO3) as a template	Homo sapiens
additional information	inhibitory activity of thiosugar derivatives (thiolevomannosans) is tested against alpha-mannosidase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
alpha-mannosidase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.5	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00035	-	1,6-dideoxy-1,6-episulfonyl-beta-D-mannose	best inhibitor of alpha-mannosidase	Homo sapiens
0.000385	-	1,6-dideoxy-1,6-episulfinyl-beta-D-mannose	-	Homo sapiens
0.00138	-	1,6-dideoxy-1,6-epithio-beta-D-mannose	-	Homo sapiens
0.4	-	deoxymannojirimycin	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)