Protein Variants | Comment | Organism |
---|---|---|
L809P | the mutation is associated with alpha-mannosidosis | Homo sapiens |
R750W | the mutation is associated with alpha-mannosidosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-Dideoxy-1,4-imino-D-mannitol | - |
Homo sapiens | |
swainsonine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | activates | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
260000 | - |
liver isoform B, gel filtration | Homo sapiens |
280000 | - |
liver isoform A, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00754 | - |
- |
Purification (Comment) | Organism |
---|---|
DEAE-cellulose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl alpha-D-mannopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferol + alpha-D-mannopyranose | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 62000 + 1 * 26000, liver isoform A, SDS-PAGE | Homo sapiens |
heterotrimer | 1 * 62000 + 1 * 58000 + 1 * 26000, liver isoform B, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Laman | - |
Homo sapiens |
lysosomal alpha-mannosidase | - |
Homo sapiens |
MAN2B1 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
- |
Homo sapiens |