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Literature summary for 3.2.1.24 extracted from

  • Paciotti, S.; Codini, M.; Tasegian, A.; Ceccarini, M.R.; Cataldi, S.; Arcuri, C.; Fioretti, B.; Albi, E.; Beccari, T.
    Lysosomal alpha-mannosidase and alpha-mannosidosis (2017), Front. Biosci., 22, 157-167 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
L809P the mutation is associated with alpha-mannosidosis Homo sapiens
R750W the mutation is associated with alpha-mannosidosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,4-Dideoxy-1,4-imino-D-mannitol
-
Homo sapiens
swainsonine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ activates Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
260000
-
liver isoform B, gel filtration Homo sapiens
280000
-
liver isoform A, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00754
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl alpha-D-mannopyranoside + H2O
-
Homo sapiens 4-methylumbelliferol + alpha-D-mannopyranose
-
?

Subunits

Subunits Comment Organism
heterodimer 1 * 62000 + 1 * 26000, liver isoform A, SDS-PAGE Homo sapiens
heterotrimer 1 * 62000 + 1 * 58000 + 1 * 26000, liver isoform B, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Laman
-
Homo sapiens
lysosomal alpha-mannosidase
-
Homo sapiens
MAN2B1
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
Homo sapiens