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Information on EC 2.8.1.2 - 3-mercaptopyruvate sulfurtransferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.1 Sulfurtransferases
                2.8.1.2 3-mercaptopyruvate sulfurtransferase
IUBMB Comments
The enzyme catalyses a transsulfuration reaction from 3-mercaptopyruvate to an internal cysteine residue. In the presence of a dithiol such as reduced thioredoxin or dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide. The enzyme participates in a sulfur relay process that leads to the 2-thiolation of some tRNAs and to protein urmylation by transferring sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the MOCS3 sulfurtransferase (EC 2.8.1.11).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
3-mercaptopyruvate sulfurtransferase, 3-mercaptopyruvate sulphurtransferase, 3-mercaptopyruvate:cyanide sulfurtransferase, 3-MPST, 3-MST, 3MST, beta-mercaptopyruvate sulfurtransferase, beta-mercaptopyruvate trans-sulfurase, mercaptopyruvate sulfurtransferase, More, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin
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3-mercaptopyruvate + [3-mercaptopyruvate sulfurtransferase]-L-cysteine = pyruvate + [3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine
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(1a)
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[3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine + reduced thioredoxin = hydrogen sulfide + [3-mercaptopyruvate sulfurtransferase]-L-cysteine + oxidized thioredoxin
show the reaction diagram
(1b)
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