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Information on EC 1.14.11.2 - procollagen-proline 4-dioxygenase

for references in articles please use BRENDA:EC1.14.11.2

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IUBMB Comments

Requires Fe2+ and ascorbate.The enzyme, which is located within the lumen of the endoplasmic reticulum, catalyses the 4-hydroxylation of prolines in -X-Pro-Gly- sequences. The 4-hydroxyproline residues are essential for the formation of the collagen triple helix. The enzyme forms a complex with protein disulfide isomerase and acts not only on procollagen but also on more than 15 other proteins that have collagen-like domains.

The enzyme appears in viruses and cellular organisms

Synonyms
prolyl 4-hydroxylase, prolyl-4-hydroxylase, p4ha1, egln3, p4ha2, hypoxia-inducible factor prolyl hydroxylase, hif prolyl hydroxylase, proline hydroxylase, c-p4h, prolyl-4-hydroxylases, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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