Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bovine serum albumin | activation | Gallus gallus | |
bovine serum albumin | activation | Homo sapiens | |
catalase | activation | Gallus gallus | |
catalase | activation | Homo sapiens | |
dithiothreitol | activation | Gallus gallus | |
dithiothreitol | activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
daunorubicin | irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions | Gallus gallus | |
daunorubicin | irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions | Homo sapiens | |
doxorubicin | irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions | Gallus gallus | |
doxorubicin | irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Gallus gallus | |
Fe2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration | Gallus gallus |
using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Gallus gallus | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? | |
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Homo sapiens | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gallus gallus |
37 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Gallus gallus | |
ascorbate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
doxorubicin | competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate | Gallus gallus | |
0.04 | - |
doxorubicin | competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate | Homo sapiens |