Literature summary for 1.14.11.2 extracted from

Choi, K.O.; Lee, T.; Lee, N.; Kim, J.H.; Yang, E.G.; Yoon, J.M.; Kim, J.H.; Lee, T.G.; Park, H.
Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger (2005), Mol. Pharmacol., 68, 1803-1809.

Search for more literature for 1.14.11.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	required for activity	Homo sapiens
Zinc	PHD2 contains a MYND zinc finger domain (Myeloid translocation protein 8, Nervy, and DEAF1) that inhibits the catalytic activity in vivo	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni2+-affinity chromatography and HiLoad Superdex200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2	-	Homo sapiens	hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
HIF-1alpha-specific prolyl-hydroxylase	-	Homo sapiens
hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2	-	Homo sapiens
PHD2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ascorbate	2 mM	Homo sapiens
O2	-	Homo sapiens

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Release 2023.1 (January 2023)