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Literature summary for 1.14.11.2 extracted from

  • Franklin, T.J.; Morris, W.P.; Edwards, P.N.; Large, M.S.; Stephenson, R.
    Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones (2001), Biochem. J., 353, 333-338.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Inhibitors

Inhibitors Comment Organism Structure
1,4-dihydrophenanthroline-4-one-3-carboxylic acid purified enzyme, competitive inhibitor of 2-oxoglutarate Gallus gallus
1,4-dihydrophenanthroline-4-one-3-carboxylic acid potent competitive inhibitor of collagen hydroxylation in the oestradiol-stimulated uterus in vivo Rattus norvegicus
8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenanthrolin-4-one-3-carboxylic acid purified enzyme, competitive inhibitor of 2-oxoglutarate Gallus gallus
8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenanthrolin-4-one-3-carboxylic acid potent competitive inhibitor of collagen hydroxylation in the oestradiol-stimulated uterus in vivo Rattus norvegicus
additional information inhibition of the purified enzyme and of collagen hydroxylation in embryonic tendon fibroblast by novel phenanthrolines, structure-activity relationships Gallus gallus
additional information inhibition of the secretion of procollagen in foreskin fibroblasts by novel phenanthrolines, structure-activity relationships Homo sapiens
phenanthrolines potent competitive inhibitors inhibitory of purified enzyme; potent competitive inhibitors of collagen hydroxylation in embryonic tendon cells in vitro Gallus gallus
phenanthrolines potent competitive inhibitors of collagen hydroxylation in foreskin fibroblasts in vitro Homo sapiens
phenanthrolines
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
 Sprague-Dawley strain
-
Rattus norvegicus
-
 female, oestradiol-treated
-
Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley strain
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo leg Gallus gallus
-
fibroblast foreskin Homo sapiens
-
tendon embryo Gallus gallus
-
uterus
-
 Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000166
-
 8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenanthrolin-4-one-3-carboxylic acid purified enzyme Gallus gallus
0.00065
-
 1,4-dihydrophenanthroline-4-one-3-carboxylic acid purified enzyme Gallus gallus