Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.2 extracted from

  • Merriweather, A.; Guenzler, V.; Brenner, M.; Unnasch, T.R.
    Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase (2001), Mol. Biochem. Parasitol., 116, 185-197.
    View publication on PubMed
Search for more literature for 1.14.11.2

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin activation Onchocerca volvulus
catalase activation Onchocerca volvulus
dithiothreitol activation Onchocerca volvulus

Cloned(Commentary)

Cloned (Comment) Organism
identification of three cDNAs encoding putative alpha subunits of the enzyme, co-expression of one of these with protein-disulfide isomerase in a catalytically active form in an insect system, genomic structure Onchocerca volvulus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Brugia malayi
Coumalic acid
-
 Brugia malayi
daunorubicin
-
 Brugia malayi
doxorubicin
-
 Brugia malayi
Pyridine 2,4-dicarboxylate not inhibitory Brugia malayi

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Onchocerca volvulus

Organism

Organism UniProt Comment Textmining
Brugia malayi
-
-
-
Onchocerca volvulus Q95W51
-
-
Onchocerca volvulus Q95W53
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protocollagen + 2-oxoglutarate + O2
-
 Onchocerca volvulus 4-hydroxyproline containing protocollagen + succinate + CO2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Onchocerca volvulus

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
 Onchocerca volvulus
ascorbate
-
 Onchocerca volvulus