EC Number   |
Expression |
Reference |
|---|
   1.14.11.2 | down |
endothelin-1 inhibits PHD2 expression and promoter activity by 50% to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression |
713361 |
| 1.14.11.2 | down |
P4H alphaII or alphaIII null mice with 20% of wild-type enzyme activity do not show an abnormal phenotype, while P4H alpha I null mutants die at day E10.5 and show an overall developmental delay and rupture of the basement membranes due to a lack of collgane IV, overview |
695593 |
| 1.14.11.2 | up |
after apoptosis of H9c2 cells is induced by DOX, PHD3 expression is upregulated in a time-dependent manner, whereas the expression of PHD1 or PHD2 is constant |
711115 |
| 1.14.11.2 | up |
in mycelia, all P4Hs are downregulated in response to hypoxia, but the expression of PcP4H1 is most affected. Pc4H1 is upregulated more than 110fold at the onset of infection, and Pc4H5 is upregulated 7fold, while the expression of other P4Hs is unchanged |
-, 764072 |
| 1.14.11.2 | up |
mechanical stretch increases MMP-2 and P4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 significantly attenuates the stretch-induced upregulation of P4H alpha1 expression, whereas blockade of the ERK1/2 pathway has no effect on P4H alpha1 expression |
745084 |
| 1.14.11.2 | up |
P4H alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer |
765458 |
| 1.14.11.2 | up |
PHD2 is hypoxia-inducible by HIF-1alpha |
712477 |
| 1.14.11.2 | up |
the activity of the enzyme (P4H) in liver and swim bladder shows similar trend, showing first increase and then decrease with increasing dietary hydroxyproline. Increased dietary hydroxyproline content corresponds with significant decrease in the mRNA level of P4Halphas in swim bladder |
764687 |
| 1.14.11.2 | up |
the enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling |
-, 745084 |
| 1.14.11.2 | up |
the expressions of P4HAs and P4HB are regulated by multiple cellular factors, including cytokines, transcription factors, and microRNAs. P4HAs and P4HB are highly expressed in many tumors. P4HB expression is significantly upregulated in a variety of cancers, including HCC, RCC, glioma, GC, and melanoma, and its upregulation correlates with cancer metastasis and invasion |
763830 |
