Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required for activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Mus musculus |
expression in insect cells and HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
poly(L-Pro) | 0.03 mM, 50% inhibition | Homo sapiens | |
Pyridine-2,4-dicarboxylate | 0.011 mM, 50% inhibition | Homo sapiens | |
Pyridine-2,5-dicarboxylate | 0.007 mM, 50% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
Fe2+ | - |
Homo sapiens | |
0.02 | - |
2-oxoglutarate | - |
Homo sapiens | |
0.024 | - |
(Pro-Pro-Gly)10 | - |
Homo sapiens | |
0.37 | - |
ascorbate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Rattus norvegicus | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Mus musculus | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7Z4N8 | - |
- |
Mus musculus | Q6W3F0 | - |
- |
Rattus norvegicus | Q6W3E9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | adult | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
skin | fetal | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(Pro-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Homo sapiens | trans-4-hydroxy-L-proline (Pro-Pro-Gly)10 + succinate + CO2 | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Homo sapiens | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Rattus norvegicus | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Mus musculus | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | probably a alpha(III)2, PDI2 tetramer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
C-P4H alpha subunit (III) | - |
Homo sapiens |
C-P4H alpha(III) | - |
Rattus norvegicus |
C-P4H alpha(III) | - |
Mus musculus |