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Literature summary for 1.14.11.2 extracted from

  • Fu, J.; Taubman, M.B.
    Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway (2010), J. Biol. Chem., 285, 8927-8935.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H196R inactive mutant Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
desferrioxamine
-
Rattus norvegicus
dimethyl oxalylglycine DMOG, the effect is HIF-independent Rattus norvegicus
additional information hypoxia inhibits the enzyme Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information EGLN3 contains a conserved iron-binding motif, of which two histidine residues, His135 and His196, are critical for its enzymatic activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
egg-laying abnormal-9 prolyl hydroxylase
-
Rattus norvegicus
EGLN prolyl hydroxylase
-
Rattus norvegicus
EGLN3
-
Rattus norvegicus
EGLN3 hydroxylase
-
Rattus norvegicus
prolyl hydroxylase
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism pharmacologic inactivation of EGLN3 hydroxylase results in activation of the canonical NF-kappaB pathway Rattus norvegicus
additional information exogenous expression of wild-type EGLN3, but not of its catalytically inactive mutant, significantly inhibits NF-kappaB activation induced by overexpressed TRAF2 or IkappaB kinase 2, overview. Deletion of EGLN3 by small interfering RNAs leads to activation of NF-kappaB Rattus norvegicus
physiological function egg-laying abnormal-9 prolyl hydroxylases regulate the stability and thereby the activity of the alpha-subunits of hypoxia-inducible factor through its ability to catalyze their hydroxylation. EGLN3 promotes differentiation of C2C12 skeletal myoblasts. EGLN3 is a negative regulator of NF-kappaB, and its prolyl hydroxylase activity is required for this effect. EGLN3 is involved in mediating myogenic differentiation, which is HIF-independent Rattus norvegicus