Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bovine serum albumin | activation | Gallus gallus | |
catalase | activation | Gallus gallus | |
dithiothreitol | activation | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-mandelate | - |
Gallus gallus | |
(-)-mandelate | - |
Gallus gallus | |
1,2,3-trihydroxybenzene | - |
Gallus gallus | |
1,2-dihydroxybenzene | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
1,3-dihydroxybenzene | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
1,4-dihydroxybenzene | - |
Gallus gallus | |
2,3-Dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
2,4-Dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
2,5-Dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
2,6-dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
2-Hydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
3,4,5-Trihydroxybenzoate | - |
Gallus gallus | |
3,4-dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
3,4-dihydroxycinnamate | competitive with respect to 2-oxoglutarate and ascorbate | Gallus gallus | |
3,4-dihydroxymandelate | competitive with respect to 2-oxoglutarate and ascorbate and noncompetitive with respect to Fe2+ | Gallus gallus | |
3,4-Dihydroxyphenylacetate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
3,4-Dihydroxyphenylpropionate | competitive with respect to 2-oxoglutarate and ascorbate | Gallus gallus | |
3,5-Dihydroxybenzoate | competitive with respect to 2-oxoglutarate and ascorbate, noncompetitive with respect to Fe2+ | Gallus gallus | |
3-hydroxybenzoate | - |
Gallus gallus | |
4-hydroxybenzoate | competitive with respect to 2-oxoglutarate, and noncompetitive with respect to ascorbate | Gallus gallus | |
Benzene 1,4-dicarboxylate | competitive inhibition with respect to ascorbate | Gallus gallus | |
L-galactono gamma-lactone | - |
Gallus gallus | |
phenylacetate | - |
Gallus gallus | |
Pyridine 2,4-dicarboxylate | uncompetitive inhibition with respect to ascorbate | Gallus gallus | |
Pyridine 2,5-dicarboxylate | uncompetitive inhibition with respect to ascorbate | Gallus gallus | |
pyridine 2-carboxylate | uncompetitive inhibition with respect to ascorbate | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Gallus gallus | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? | |
additional information | thermal denaturing of the triple-helical conformation of the substrate before hydroxylation | Gallus gallus | ? | - |
? | |
protocollagen + 2-oxoglutarate + O2 | - |
Gallus gallus | 4-hydroxyproline containing protocollagen + succinate + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gallus gallus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Gallus gallus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6-Isopropylideneascorbate | can replace ascorbate | Gallus gallus | |
ascorbate | - |
Gallus gallus | |
D-isoascorbate | can replace ascorbate | Gallus gallus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
3,4-dihydroxybenzoate | - |
Gallus gallus | |
0.009 | - |
3,4-Dihydroxyphenylacetate | - |
Gallus gallus | |
0.009 | - |
3,4-dihydroxymandelate | - |
Gallus gallus | |
0.013 | - |
3,4-Dihydroxyphenylpropionate | - |
Gallus gallus | |
0.018 | - |
3,4-dihydroxycinnamate | - |
Gallus gallus | |
0.025 | - |
1,2-dihydroxybenzene | - |
Gallus gallus | |
0.03 | - |
3,4,5-Trihydroxybenzoate | - |
Gallus gallus | |
0.03 | - |
1,2,3-trihydroxybenzene | - |
Gallus gallus | |
0.07 | - |
2,3-Dihydroxybenzoate | - |
Gallus gallus | |
0.53 | - |
2,4-Dihydroxybenzoate | - |
Gallus gallus | |
1.1 | - |
2,6-dihydroxybenzoate | - |
Gallus gallus | |
1.4 | - |
2,5-Dihydroxybenzoate | - |
Gallus gallus | |
2.3 | - |
2-Hydroxybenzoate | - |
Gallus gallus | |
3.2 | - |
4-hydroxybenzoate | - |
Gallus gallus | |
9 | - |
3,5-Dihydroxybenzoate | - |
Gallus gallus | |
10.2 | - |
1,3-dihydroxybenzene | - |
Gallus gallus | |
14 | - |
1,4-dihydroxybenzene | - |
Gallus gallus | |
20 | - |
phenylacetate | value above | Gallus gallus | |
20 | - |
3-hydroxybenzoate | value above | Gallus gallus | |
20 | - |
(-)-mandelate | value above | Gallus gallus | |
20 | - |
L-galactono gamma-lactone | value above | Gallus gallus | |
20 | - |
(+)-mandelate | value above | Gallus gallus |