Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required for activity | Drosophila melanogaster | |
ascorbate | required for activity | Arabidopsis thaliana | |
ascorbate | required for activity | Paramecium bursaria Chlorella virus-1 | |
ascorbate | required for activity | Homo sapiens | |
ascorbate | required for activity | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
poly(L-proline) | - |
Drosophila melanogaster | |
poly(L-proline) | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
poly(L-proline) | molecular weight 20000-40000 Da | Arabidopsis thaliana | |
0.0004 | - |
Fe2+ | - |
Paramecium bursaria Chlorella virus-1 | |
0.002 | - |
Fe2+ | - |
Caenorhabditis elegans | |
0.002 | - |
poly(L-proline) | molecular weight 5000-10000 Da | Arabidopsis thaliana | |
0.003 | - |
Fe2+ | - |
Drosophila melanogaster | |
0.004 | - |
Fe2+ | - |
Homo sapiens | |
0.006 | - |
Fe2+ | - |
Homo sapiens | |
0.016 | - |
Fe2+ | - |
Arabidopsis thaliana | |
0.018 | - |
(L-Pro-L-Pro-Gly)10 | - |
Drosophila melanogaster | |
0.018 | - |
(L-Pro-L-Pro-Gly)10 | - |
Homo sapiens | |
0.02 | - |
2-oxoglutarate | - |
Paramecium bursaria Chlorella virus-1 | |
0.02 | - |
(L-Pro-L-Pro-Gly)10 | - |
Caenorhabditis elegans | |
0.022 | - |
2-oxoglutarate | - |
Homo sapiens | |
0.06 | - |
(L-Pro-L-Pro-Gly)10 | - |
Arabidopsis thaliana | |
0.08 | - |
2-oxoglutarate | - |
Caenorhabditis elegans | |
0.084 | - |
2-oxoglutarate | - |
Drosophila melanogaster | |
0.095 | - |
(L-Pro-L-Pro-Gly)10 | - |
Homo sapiens | |
0.1 | - |
poly(L-proline) | molecular weight 20000-40000 Da | Paramecium bursaria Chlorella virus-1 | |
0.13 | - |
2-oxoglutarate | - |
Arabidopsis thaliana | |
0.3 | - |
ascorbate | - |
Drosophila melanogaster | |
0.3 | - |
ascorbate | - |
Arabidopsis thaliana | |
0.3 | - |
ascorbate | - |
Paramecium bursaria Chlorella virus-1 | |
0.33 | - |
ascorbate | - |
Homo sapiens | |
0.34 | - |
ascorbate | - |
Homo sapiens | |
0.35 | - |
ascorbate | - |
Caenorhabditis elegans | |
2.9 | - |
(L-Pro-L-Pro-Gly)10 | - |
Paramecium bursaria Chlorella virus-1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for activity | Drosophila melanogaster | |
Fe2+ | required for activity | Arabidopsis thaliana | |
Fe2+ | required for activity | Paramecium bursaria Chlorella virus-1 | |
Fe2+ | required for activity | Homo sapiens | |
Fe2+ | required for activity | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Arabidopsis thaliana | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Paramecium bursaria Chlorella virus-1 | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | Caenorhabditis elegans | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Caenorhabditis elegans | Q20065 | alpha-2 subunit | - |
Drosophila melanogaster | - |
- |
- |
Homo sapiens | O15460 | alpha-subunit | - |
Homo sapiens | P13674 | alpha-subunit | - |
Paramecium bursaria Chlorella virus-1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Paramecium bursaria Chlorella virus-1 | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Homo sapiens | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Caenorhabditis elegans | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2 | - |
Paramecium bursaria Chlorella virus-1 | (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2 | - |
Caenorhabditis elegans | (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Drosophila melanogaster | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Arabidopsis thaliana | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Paramecium bursaria Chlorella virus-1 | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Homo sapiens | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Caenorhabditis elegans | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
poly(L-proline) + 2-oxoglutarate + O2 | - |
Paramecium bursaria Chlorella virus-1 | poly trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
poly(L-proline) + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | poly(trans-4-hydroxy-L-proline) + succinate + CO2 | - |
r | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Paramecium bursaria Chlorella virus-1 | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
procollagen L-proline + 2-oxoglutarate + O2 | - |
Caenorhabditis elegans | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Drosophila melanogaster |
tetramer | - |
Arabidopsis thaliana |
tetramer | - |
Paramecium bursaria Chlorella virus-1 |
tetramer | - |
Homo sapiens |
tetramer | - |
Caenorhabditis elegans |
Synonyms | Comment | Organism |
---|---|---|
AT-P4H-1 | - |
Arabidopsis thaliana |
CePHY-1/PHY-2/PDI2 | - |
Caenorhabditis elegans |
DmP4H | - |
Drosophila melanogaster |
HuPH4-I | - |
Homo sapiens |
HuPH4-II | - |
Homo sapiens |
PBCV-1 P4H | - |
Paramecium bursaria Chlorella virus-1 |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
poly(L-proline) | molecular weight 20000-40000 Da | Homo sapiens | |
0.0005 | - |
poly(L-proline) | molecular weight 5000-10000 Da | Homo sapiens | |
0.003 | - |
poly(L-proline) | molecular weight 20000-40000 Da | Drosophila melanogaster | |
0.018 | - |
poly(L-proline) | molecular weight 5000-10000 Da | Drosophila melanogaster | |
0.02 | - |
poly(L-proline) | molecular weight 20000-40000 Da | Homo sapiens | |
0.095 | - |
poly(L-proline) | molecular weight 5000-10000 Da | Homo sapiens |