BRENDA - Reference to 1.14.11.2; Id = 744594

diagnostics

the prolyl-4-hydroxylase alpha subunit 2 is a biomarker for breast cancer progression. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status

Homo sapiens

medicine

the prolyl-4-hydroxylase alpha subunit 2 is a potential therapeutic target for the disorders associated with increased collagen deposition and a biomarker for breast cancer progression

Homo sapiens

gene P4HA2, enzyme expression analysis, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression

Homo sapiens

additional information

recombinant expression of sh-P4HA2-1 and sh-P4HA2-2 in breast cancer cell lines HMT-3522 T4-2, MDA-MB-231, ZR-75-1, and MDA-MB-157 for gene silencing, phenotypes, detailed overview

Homo sapiens

1,4-dihydrophenanthrolin-4-one-3-carboxylic acid

1,4,DPCA

Homo sapiens

extracellular matrix

-

Homo sapiens

31012

-

procollagen L-proline + 2-oxoglutarate + O2

Homo sapiens

-

procollagen trans-4-hydroxy-L-proline + succinate + CO2

-

?

Homo sapiens

O15460

-

breast

-

Homo sapiens

-

breast cancer cell

P4HA2 mRNA levels are significantly upregulated in breast cancer compared to normal mammary tissue

Homo sapiens

-

HMT-3522 T4-2 cell

-

Homo sapiens

-

mammary gland

-

Homo sapiens

-

MDA-MB-157 cell

-

Homo sapiens

-

MDA-MB-231 cell

-

Homo sapiens

-

ZR-75-1 cell

-

Homo sapiens

-

procollagen L-proline + 2-oxoglutarate + O2

-

744594

Homo sapiens

procollagen trans-4-hydroxy-L-proline + succinate + CO2

-

?

collagen prolyl-4-hydroxylase alpha subunit 2

-

Homo sapiens

P4ha2

-

Homo sapiens

prolyl-4-hydroxylase alpha subunit 2

-

Homo sapiens

diagnostics

the prolyl-4-hydroxylase alpha subunit 2 is a biomarker for breast cancer progression. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status

Homo sapiens

medicine

the prolyl-4-hydroxylase alpha subunit 2 is a potential therapeutic target for the disorders associated with increased collagen deposition and a biomarker for breast cancer progression

Homo sapiens

gene P4HA2, enzyme expression analysis, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression

Homo sapiens

additional information

recombinant expression of sh-P4HA2-1 and sh-P4HA2-2 in breast cancer cell lines HMT-3522 T4-2, MDA-MB-231, ZR-75-1, and MDA-MB-157 for gene silencing, phenotypes, detailed overview

Homo sapiens

1,4-dihydrophenanthrolin-4-one-3-carboxylic acid

1,4,DPCA

Homo sapiens

extracellular matrix

-

Homo sapiens

31012

-

procollagen L-proline + 2-oxoglutarate + O2

Homo sapiens

-

procollagen trans-4-hydroxy-L-proline + succinate + CO2

-

?

breast

-

Homo sapiens

-

breast cancer cell

P4HA2 mRNA levels are significantly upregulated in breast cancer compared to normal mammary tissue

Homo sapiens

-

HMT-3522 T4-2 cell

-

Homo sapiens

-

mammary gland

-

Homo sapiens

-

MDA-MB-157 cell

-

Homo sapiens

-

MDA-MB-231 cell

-

Homo sapiens

-

ZR-75-1 cell

-

Homo sapiens

-

procollagen L-proline + 2-oxoglutarate + O2

-

744594

Homo sapiens

procollagen trans-4-hydroxy-L-proline + succinate + CO2

-

?

malfunction

silencing P4HA2 expression or treatment with a P4HA inhibitor significantly inhibits cell proliferation and suppresses aggressive phenotypes of breast cancer cells in 3D culture, accompanied by reduced deposition of collagen I and IV. Knockdown of P4HA2 inhibits mammary tumor growth and metastasis to lungs in xenograft models. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status. Kaplan-Meier survival analysis, overview

Homo sapiens

physiological function

collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2) hydroxylates proline residues in -X-Pro-Gly- sequences. Expression and function of P4HA2 in breast cancer progression, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression

Homo sapiens

malfunction

silencing P4HA2 expression or treatment with a P4HA inhibitor significantly inhibits cell proliferation and suppresses aggressive phenotypes of breast cancer cells in 3D culture, accompanied by reduced deposition of collagen I and IV. Knockdown of P4HA2 inhibits mammary tumor growth and metastasis to lungs in xenograft models. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status. Kaplan-Meier survival analysis, overview

Homo sapiens

physiological function

collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2) hydroxylates proline residues in -X-Pro-Gly- sequences. Expression and function of P4HA2 in breast cancer progression, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression

Homo sapiens

745180

Timmins

Understanding how prolyl-4-hy ...

Homo sapiens

J. Am. Chem. Soc.

139

9855-9866

2017

-

6

-

1

-

1

-

1

-

2

-

1

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2

-

6

-

1

-

1

-

1

-

1

-

3

-

743946

Schnicker

Structural analysis of cofact ...

Bacillus anthracis

Acta Crystallogr. Sect. D

72

675-681

2016

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

3

-

744764

Cao

Overexpression of prolyl-4-hy ...

Mus musculus, Mus musculus ApoE

Dis. Markers

2016

1701637

2016

-

1

-

1

-

1

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2

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4

-

2

-

3

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1

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1

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1

-

2

-

2

-

2

-

745342

Schnicker

Bacillus anthracis prolyl 4-h ...

Bacillus anthracis

J. Biol. Chem.

291

13360-13374

2016

-

1

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2

-

1

-

6

-

1

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3

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4

1

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1

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1

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1

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2

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1

-

1

-

3

-

1

-

1

-

1

-

744826

Huang

-

Prolyl-4-hydroxylase-alpha1 i ...

Mus musculus

Eur. Heart J.

17

C49-C58

2015

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

745084

Liu

Mechanical stretch promotes m ...

Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar

Int. J. Biochem. Cell Biol.

62

15-23

2015

-

2

-

1

-

2

-

4

-

7

-

4

2

-

2

-

2

-

1

-

2

-

7

-

2

-

2

-

2

-

744594

Xiong

Prolyl-4-hydroxylase alpha su ...

Homo sapiens

BMC Cancer

14

1-1

2014

-

2

1

-

1

-

1

-

1

-

1

-

1

-

7

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1

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3

-

2

1

-

1

-

1

-

1

-

1

-

7

-

1

-

2

-

725653

Pektas

Substrate preference of the HI ...

Homo sapiens

J. Inorg. Biochem.

126

55-60

2013

-

1

-

4

-

1

-

1

-

2

-

1

-

4

1

-

1

-

4

-

1

-

2

-

1

-

4

1

-

4

727164

Vasta

Bioavailable affinity label fo ...

Caenorhabditis elegans, Homo sapiens

Bioorg. Med. Chem.

21

3597-3601

2013

-

1

-

2

-

6

-

1

-

1

-

4

-

1

-

1

-

2

-

1

-

1

-

1

-

727976

Song

Prolyl hydroxylase domain prot ...

Homo sapiens

J. Biol. Chem.

288

9662-9674

2013

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

728416

Duran

HIF-independent role of prolyl ...

Homo sapiens

Oncogene

32

4549-4556

2013

-

2

-

1

-

1

-

1

-

2

-

1

-

2

-

727194

Munemasa

Role of lumenal domain on intr ...

Nicotiana tabacum

Biosci. Biotechnol. Biochem.

76

2159-2161

2012

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

727902

Zhang

Skp1 prolyl 4-hydroxylase of D ...

Dictyostelium discoideum

J. Biol. Chem.

287

2006-2016

2012

-

5

-

1

-

1

-

1

-

728198

Chen

Roles of individual prolyl-4-h ...

Mus musculus

J. Physiol.

590

4079-4091

2012

-

2

-

1

-

2

-

1

-

1

-

726919

Yum

Hyperoxia attenuates the inhib ...

Homo sapiens

Biochem. Pharmacol.

82

485-490

2011

-

2

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

711115

Liu

Prolyl hydroxylase 3 interacts ...

Rattus norvegicus

Biochem. Biophys. Res. Commun.

401

231-237

2010

-

1

-

1

-

1

-

2

-

1

-

1

-

1

2

1

-

711221

Culpepper

Crystal structure of prolyl 4- ...

Bacillus anthracis

Biochemistry

49

124-133

2010

-

1

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1

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2

-

5

-

3

1

2

-

1

-

1

-

2

-

3

1

-

1

-

712088

Xue

Prolyl hydroxylase-3 is down-r ...

Homo sapiens

Gastroenterology

138

606-615

2010

-

1

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1

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3

-

4

-

1

-

5

-

1

-

1

-

4

-

1

-

1

-

712477

Vogel

Prolyl hydroxylase domain (PHD ...

Homo sapiens

J. Biol. Chem.

285

33756-33763

2010

-

2

-

1

-

2

-

2

-

1

-

712495

Fu

Prolyl hydroxylase EGLN3 regul ...

Rattus norvegicus

J. Biol. Chem.

285

8927-8935

2010

-

1

-

3

-

1

-

1

-

5

-

1

-

3

-

1

-

3

-

712799

Tennant

HIF prolyl hydroxylase-3 media ...

Homo sapiens

J. Mol. Med.

88

839-849

2010

1

-

1

-

1

-

1

-

2

-

3

-

1

-

4

-

1

-

1

-

1

-

1

-

3

-

1

-

2

-

713361

Spinella

Endothelin-1 inhibits prolyl h ...

Homo sapiens

PLoS ONE

5

e11241

2010

-

1

-

1

-

6

-

1

-

1

-

6

-

1

-

695550

Gorres

Direct and continuous assay fo ...

Homo sapiens

Anal. Biochem.

386

181-185

2009

-

1

3

-

1

-

1

-

2

-

4

-

2

1

-

2

1

-

1

-

3

-

1

-

1

-

4

-

1

-

2

1

-

1

-

696584

Stein

Production of bioactive, post- ...

Homo sapiens

Biomacromolecules

10

2640-2645

2009

-

1

-

4

-

2

-

1

-

1

-

698933

Koski

The crystal structure of an al ...

Chlamydomonas reinhardtii

J. Biol. Chem.

284

25290-25301

2009

-

1

10

-

2

19

-

1

-

1

-

3

-

1

-

5

1

4

-

16

-

1

-

1

10

-

2

-

19

-

1

-

1

-

1

-

5

1

-

16

-

1

-

700909

Gorres

Stringency of the 2-His-1-Asp ...

Homo sapiens

PLoS ONE

4

e7635

2009

-

1

-

5

-

7

-

1

-

1

-

2

-

1

-

2

1

3

1

-

1

-

1

-

5

-

7

-

1

-

1

-

1

-

2

1

-

1

-

701253

Chowdhury

Structural basis for binding o ...

Homo sapiens

Structure

17

981-989

2009

-

1

-

1

-

2

-

1

-

1

-

3

1

4

-

1

-

1

-

1

-

2

-

1

-

3

1

-

1

-

685287

Gorres

Conformational preferences of ...

Homo sapiens

Biochemistry

47

9447-9455

2008

-

3

-

1

-

2

-

3

-

3

-

3

-

1

-

3

-

3

-

685383

Zhang

Role of NonO-histone interacti ...

Homo sapiens

Biochim. Biophys. Acta

1783

1517-1528

2008

-

1

-

2

-

1

-

1

-

1

-

687690

Keskiaho

Characterization of a novel Ca ...

Caenorhabditis elegans

J. Biol. Chem.

283

10679-10689

2008

-

1

-

1

-

5

-

1

2

-

2

-

2

-

1

-

6

2

-

1

-

1

-

1

-

5

-

1

2

-

2

-

1

-

6

2

-

689985

Leite

An oxygen molecular sensor, th ...

Perkinsus olseni

Protist

159

355-368

2008

-

1

-

1

-

1

-

1

-

1

-

1

-

695356

Miller

Expression, purification, crys ...

Bacillus anthracis

Acta Crystallogr. Sect. F

64

788-791

2008

-

1

-

1

-

1

-

4

-

1

-

1

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

695593

Myllyharju

Prolyl 4-hydroxylases, key enz ...

Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus

Ann. Med.

40

402-417

2008

5

1

-

2

-

51

8

3

6

-

11

-

6

-

1

6

-

22

6

18

-

1

30

-

5

1

-

2

-

51

30

8

3

6

-

11

-

1

-

22

6

-

1

6

1

-

700388

Qi

Prolyl 4-hydroxylation regulat ...

Homo sapiens

Nature

455

421-424

2008

-

1

-

1

-

3

-

2

-

3

-

2

-

1

-

1

-

2

-

3

-

2

-

671264

Li

Expression and actions of HIF ...

Rattus norvegicus

Am. J. Physiol. Renal Physiol.

292

F207-F216

2007

-

1

-

2

-

3

-

2

-

3

-

1

-

3

-

2

-

674980

Neubauer

Fermentation process for tetra ...

Homo sapiens

J. Biotechnol.

128

308-321

2007

-

1

-

1

-

4

-

1

2

-

1

-

1

-

1

-

684766

Meng

Increased expression of collag ...

Homo sapiens

Arch. Oral Biol.

52

1209-1214

2007

-

1

-

2

-

1

-

1

-

1

-

684797

Cho

-

Cloning and expression analysi ...

Sus scrofa

Asian-Australas. J. Anim. Sci.

20

1655-1661

2007

-

1

-

1

-

2

-

1

-

2

-

684836

Imaoka

Isolation of Xenopus HIF-proly ...

Xenopus laevis

Biochem. Biophys. Res. Commun.

355

419-425

2007

-

2

-

1

-

1

-

2

-

2

-

1

-

2

-

684987

Villar

Identification of a region on ...

Homo sapiens

Biochem. J.

408

231-240

2007

-

1

-

3

-

3

1

2

-

2

-

3

1

-

686296

West

Prolyl 4-hydroxylase-1 mediate ...

Dictyostelium discoideum

Development

134

3349-3358

2007

-

1

-

4

-

1

-

1

-

1

-

687351

Choi

-

An assay method for screening ...

Rattus norvegicus

J. Appl. Pharmacol.

15

261-265

2007

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

687622

Koivunen

An endoplasmic reticulum trans ...

Homo sapiens

J. Biol. Chem.

282

30544-30552

2007

-

1

-

2

-

5

-

1

-

2

-

1

-

2

-

1

-

2

-

687660

Koski

The active site of an algal pr ...

Chlamydomonas reinhardtii

J. Biol. Chem.

282

37112-37123

2007

-

1

11

-

11

-

3

-

1

-

6

-

1

11

-

11

-

1

-

6

-

689464

Keskiaho

Chlamydomonas reinhardtii has ...

Chlamydomonas reinhardtii

Plant Cell

19

256-269

2007

-

1

-

1

-

3

8

-

1

3

-

1

-

6

1

-

1

3

-

1

-

1

-

3

8

-

1

3

-

6

1

-

671867

Tian

Characterization of different ...

Homo sapiens

Biochem. J.

397

179-186

2006

-

1

-

2

-

1

-

3

-

1

-

2

-

672888

Cervera

An alternatively spliced trans ...

Homo sapiens

Cancer Lett.

233

131-138

2006

-

1

-

1

-

3

-

1

-

2

-

1

-

3

-

1

-

674528

Chen

Human prolyl-4-hydroxylase alp ...

Homo sapiens

J. Biol. Chem.

281

10849-10855

2006

-

3

-

2

-

676834

Cummins

Prolyl hydroxylase-1 negativel ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

103

18154-18159

2006

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

3

-

676877

McDonough

Cellular oxygen sensing: Cryst ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

103

9814-9819

2006

-

1

-

2

1

-

3

-

1

-

1

2

-

1

-

1

-

2

1

-

1

-

1

-

659449

Tiainen

Characterization of a second A ...

Arabidopsis thaliana

J. Biol. Chem.

280

1142-1148

2005

-

1

-

2

8

-

1

-

7

-

6

1

-

2

-

1

-

2

8

-

1

-

6

1

-

671710

Li

Assembly of homotrimeric type ...

Homo sapiens

Biochem. Biophys. Res. Commun.

336

375-385

2005

-

1

-

5

-

1

-

2

-

1

-

1

-

673465

Callapina

Nitric oxide reverses desferri ...

Homo sapiens

Exp. Cell Res.

306

274-284

2005

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

674423

van der Wel

The Skp1 prolyl hydroxylase fr ...

Dictyostelium discoideum, Dictyostelium discoideum AX3

J. Biol. Chem.

280

14645-14655

2005

-

1

-

3

1

-

2

-

6

-

1

-

1

-

4

-

2

-

1

2

-

1

2

-

2

3

-

1

-

2

-

1

-

1

-

1

-

675764

Neubauer

High-level production of human ...

Homo sapiens

Matrix Biol.

24

59-68

2005

-

1

-

2

-

3

-

1

-

2

1

3

1

-

1

-

2

-

1

-

2

1

-

676092

Choi

Inhibition of the catalytic ac ...

Homo sapiens

Mol. Pharmacol.

68

1803-1809

2005

-

1

-

2

-

2

-

1

-

1

-

1

-

3

-

2

-

1

2

-

2

-

1

-

1

-

1

-

676492

Yuasa

Membrane-anchored prolyl hydro ...

Nicotiana tabacum

Plant J.

41

81-94

2005

-

1

-

1

-

3

-

2

-

5

-

1

-

2

-

1

-

1

-

3

-

2

-

1

-

657488

Nissi

Immunofluorescence localizatio ...

Homo sapiens, Rattus norvegicus

Acta Histochem.

106

111-121

2004

-

2

-

2

-

6

-

2

-

3

-

2

-

6

-

2

-

658745

Tuckerman

Determination and comparison o ...

Homo sapiens

FEBS Lett.

576

145-150

2004

1

-

1

-

3

-

3

-

3

-

6

-

3

-

3

-

3

-

3

-

659333

Kukkola

Collagen prolyl 4-hydroxylase ...

Caenorhabditis elegans

J. Biol. Chem.

279

18656-18661

2004

1

-

1

-

4

-

6

-

1

-

1

-

2

-

5

1

-

1

-

1

-

4

-

6

-

1

-

1

-

5

1

-

660440

Kersteen

Production of human prolyl 4-h ...

Homo sapiens

Protein Expr. Purif.

38

279-291

2004

-

1

-

2

1

-

1

-

3

-

1

-

1

-

4

1

-

2

-

1

-

2

1

-

1

-

1

-

1

-

4

1

-

2

-

657456

ekkala

Crystallization of the proline ...

Homo sapiens

Acta Crystallogr. Sect. D

59

940-942

2003

-

1

-

1

-

1

-

2

-

1

-

1

2

-

1

-

1

-

1

-

1

-

1

-

1

-

657621

Petersen

Novel proline hydroxylase acti ...

Glarea lozoyensis

Appl. Microbiol. Biotechnol.

62

263-267

2003

2

-

7

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

7

-

1

-

1

-

1

-

1

-

1

-

1

-

658629

Hofbauer

Oxygen tension regulates the e ...

Rattus norvegicus

Eur. J. Biochem.

270

4515-4522

2003

-

2

-

2

-

1

-

2

-

4

-

2

-

2

-

2

-

659235

Hirsila

Characterization of the human ...

Homo sapiens

J. Biol. Chem.

278

30772-30780

2003

1

-

1

-

1

-

5

31

-

1

-

3

-

3

-

7

-

38

-

3

-

13

-

3

-

3

-

1

-

15

40

-

3

-

3

-

21

-

38

-

659249

Hieta

The peptide-substrate-binding ...

Homo sapiens

J. Biol. Chem.

278

34966-34974

2003

1

-

1

-

2

1

-

1

-

2

-

5

1

2

-

1

-

1

-

2

1

-

1

-

5

1

-

659280

Kukkola

Identification and characteriz ...

Homo sapiens, Mus musculus, Rattus norvegicus

J. Biol. Chem.

278

47685-47693

2003

1

-

3

-

3

4

-

1

-

3

-

6

-

3

-

5

1

3

-

1

-

3

-

3

-

4

-

1

-

3

-

3

-

5

1

-

659844

Myllyharju

Prolyl 4-hydroxylases, the key ...

Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Paramecium bursaria Chlorella virus-1

Matrix Biol.

22

15-24

2003

5

-

2

26

-

5

-

6

-

6

-

19

5

6

-

6

-

6

-

3

6

27

-

6

-

6

-

19

6

-

439250

Hieta

Cloning and characterization o ...

Arabidopsis thaliana

J. Biol. Chem.

277

23965-23971

2002

-

1

-

11

-

15

-

1

-

8

-

60

1

-

1

-

1

-

4

-

44

-

60

-

4

-

60

4

-

439247

Franklin

Inhibition of prolyl 4-hydroxy ...

Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley

Biochem. J.

353

333-338

2001

-

9

-

167

-

12

-

2

-

9

2

-

12

-

439248

Merriweather

Characterization and expressio ...

Brugia malayi, Onchocerca volvulus

Mol. Biochem. Parasitol.

116

185-197

2001

3

-

1

-

5

-

1

-

9

-

2

-

1

-

2

-

6

-

2

4

-

5

-

2

-

2

-

2

-

439249

Ko

Subcellular localization of pr ...

Oryctolagus cuniculus

Exp. Cell Res.

264

363-371

2001

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

439244

Wojtaszek

Ultrastructural localization a ...

Phaseolus vulgaris, Tropaeolum majus

Int. J. Biochem. Cell Biol.

31

463-477

1999

-

5

-

4

-

7

-

1

-

5

-

4

-

1

-

439245

Annunen

Cloning of the a subunit of pr ...

Drosophila melanogaster, Homo sapiens

J. Biol. Chem.

274

6790-6796

1999

-

1

-

2

-

2

6

-

2

-

7

-

1

2

-

3

4

-

2

6

-

1

2

-

2

-

2

6

-

2

-

1

2

-

3

4

-

439246

Eriksson

Evidence for 4-hydroxyproline ...

Paramecium bursaria Chlorella virus 1

J. Biol. Chem.

274

22131-22134

1999

-

1

-

12

-

1

2

-

7

-

1

-

7

1

-

1

-

1

-

1

-

12

-

1

2

-

1

-

7

1

-

1

-

439243

Annunen

The novel type II prolyl 4-hyd ...

Homo sapiens, Mus musculus

J. Biol. Chem.

273

5989-5992

1998

-

5

-

16

-

16

-

439242

Annunen

Cloning of the human prolyl 4- ...

Gallus gallus, Homo sapiens

J. Biol. Chem.

272

17342-17348

1997

-

1

-

2

8

-

2

-

3

-

1

-

17

2

-

7

2

-

2

4

-

1

2

-

2

4

8

-

2

-

1

-

17

2

-

7

2

-

439240

Lawrence

-

Purification and initial chara ...

Streptomyces griseoviridis

Biochem. J.

313

185-191

1996

2

-

13

2

-

2

-

1

-

1

-

4

1

-

1

-

4

-

2

-

13

4

2

-

2

-

1

-

4

1

-

439241

Mazzorana

Involvement of prolyl 4-hydrox ...

Homo sapiens

J. Biol. Chem.

271

29003-29008

1996

-

1

-

2

-

1

-

439238

Lamberg

Site-directed mutagenesis of t ...

Homo sapiens

J. Biol. Chem.

270

9926-9931

1995

-

1

-

13

-

1

3

-

1

-

2

-

1

-

2

-

1

2

-

1

-

13

-

1

2

3

-

1

-

1

-

2

-

439239

Helaakoski

Cloning, baculovirus expressio ...

Homo sapiens, Mus musculus

Proc. Natl. Acad. Sci. USA

92

4427-4431

1995

-

1

-

4

-

2

-

4

-

6

-

3

-

2

9

-

1

2

-

4

9

4

-

2

-

6

-

3

-

439236

Veijola

Cloning, baculovirus expressio ...

Caenorhabditis elegans

J. Biol. Chem.

269

26746-26753

1994

-

1

-

3

2

-

1

-

4

-

1

-

2

1

-

1

-

1

-

3

-

2

-

1

-

1

-

2

1

-

439237

Baader

-

Inhibition of prolyl 4-hydroxy ...

Gallus gallus

Biochem. J.

300

525-530

1994

3

-

10

-

1

-

1

-

1

-

4

-

2

-

1

-

1

7

-

3

-

1

-

10

7

-

1

-

1

-

4

-

2

-

1

-

439179

Guzman

Comparison between avian and h ...

Gallus gallus, Homo sapiens

J. Cell. Biochem.

48

172-189

1992

14

-

2

-

2

-

3

-

2

-

2

-

4

-

4

-

14

-

4

-

2

-

2

-

2

-

2

-

4

-

439189

Atreya

Interaction of prolyl 4-hydrox ...

Gallus gallus

J. Biol. Chem.

266

2852-2858

1991

3

-

7

-

1

-

2

-

1

-

2

-

10

-

1

-

7

1

-

1

-

3

-

1

-

7

-

1

-

1

-

2

-

10

-

1

-

7

1

-

439197

De Jong

The kinetics of the hydroxylat ...

Gallus gallus

Biochim. Biophys. Acta

1079

103-111

1991

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

439180

Kivirikko

Protein hydroxylation: prolyl ...

Gallus gallus, Homo sapiens, Mus musculus, Volvox carteri

FASEB J.

3

1609-1617

1989

-

28

8

-

4

-

2

-

5

-

7

4

-

4

9

-

4

-

28

9

8

-

4

-

2

-

7

4

-

439190

Hussain

Inhibition of prolyl hydroxyla ...

Gallus gallus

J. Biol. Chem.

264

7850-7855

1989

1

-

6

-

1

-

2

-

1

-

2

-

2

3

-

1

-

2

-

6

3

-

1

-

1

-

2

-

439233

Helaakoski

Molecular cloning of the a-sub ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

86

4392-4396

1989

-

1

-

2

-

1

-

439181

De Waal

Processive action of the two p ...

Gallus gallus

Biochemistry

27

150-155

1988

3

-

1

-

1

-

2

-

1

-

1

-

3

-

1

-

1

-

1

-

2

-

1

-

439182

De Waal

-

Localisation and quantificatio ...

Gallus gallus

Biochim. Biophys. Acta

953

20-25

1988

-

2

-

1

-

1

-

1

-

2

1

-

1

-

439183

Gunzler

Syncatalytic inactivation of p ...

Gallus gallus, Homo sapiens

J. Biol. Chem.

263

19498-19504

1988

6

-

4

2

-

2

-

3

-

2

-

2

-

2

-

2

-

6

-

2

-

4

-

2

-

2

-

2

-

2

-

2

-

439184

Gunzler

Syncatalytic inactivation of p ...

Gallus gallus, Homo sapiens

Biochem. J.

251

365-372

1988

6

-

4

-

2

-

3

-

2

-

2

-

2

-

2

-

2

-

6

-

2

-

4

2

-

2

-

2

-

2

-

2

-

2

-

439221

Kaska

Prolyl 4-hydroxylase from Volv ...

Helianthus tuberosus, Persea americana, Ulva intestinalis, Volvox carteri

Biochem. J.

256

257-263

1988

-

10

2

-

4

3

-

9

-

1

-

4

-

5

1

-

1

-

1

-

4

5

-

4

-

10

5

2

-

4

3

-

1

-

4

-

5

1

-

1

-

3038

Pihlajaniemi

Molecular cloning of the beta- ...

Homo sapiens

EMBO J.

6

643-649

1987

-

1

-

3

-

1

-

439185

Gunzler

Time-dependent inactivation of ...

Gallus gallus, Homo sapiens

Biochem. J.

242

163-169

1987

6

-

2

10

2

-

3

-

2

-

1

-

2

-

2

-

2

10

-

6

-

2

-

2

-

10

2

-

2

-

1

-

2

-

2

-

439186

Kivirikko

Recent developments in posttra ...

Gallus gallus, Homo sapiens, Mus musculus

Methods Enzymol.

144

96-114

1987

4

-

1

-

24

-

3

-

3

-

2

-

5

-

2

3

-

3

-

4

-

1

3

-

24

-

3

-

2

-

5

-

2

3

-

439187

Marumo

Prolyl 4-hydroxylase in the fo ...

Mytilus edulis

J. Exp. Zool.

244

365-374

1987

3

-

5

1

-

1

-

4

-

1

-

2

-

2

1

-

1

-

1

-

1

-

2

-

3

-

2

-

5

-

1

-

1

-

1

-

2

-

2

1

-

1

-

1

-

439217

Kaska

Characterization of a low-rela ...

Chlamydomonas reinhardtii

Biochem. J.

241

483-490

1987

4

-

11

4

-

1

-

5

-

1

-

4

-

1

-

1

-

3

10

-

4

-

3

-

11

10

4

-

1

-

1

-

4

-

1

-

1

-

439227

De Waal

Photoaffinity labeling of the ...

Gallus gallus

Biochim. Biophys. Acta

912

151-155

1987

-

1

-

1

-

1

-

439188

Cunliffe

Inhibition of prolyl 4-hydroxy ...

Gallus gallus

Biochem. J.

239

311-315

1986

3

-

1

-

1

2

-

1

-

2

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

2

-

2

-

1

-

1

-

439194

Majamaa

Partial identity of the 2-oxog ...

Gallus gallus

J. Biol. Chem.

261

7819-7823

1986

3

-

26

-

1

-

1

-

3

-

1

-

1

-

3

22

-

3

-

3

-

26

22

-

1

-

3

-

1

-

1

-

439218

Blankenstein

Isolation and characterization ...

Chlamydomonas reinhardtii

Planta

169

238-244

1986

1

-

1

3

-

1

-

1

-

2

-

3

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

3

-

1

-

2

-

3

1

-

1

-

439224

Koivu

Protein disulfide-isomerase re ...

Gallus gallus

Biochemistry

25

5982-5986

1986

1

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

439191

Kedersha

Characterization of the oligos ...

Gallus gallus

Biochemistry

24

5952-5960

1985

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

439216

Bolwell

Elicitor-induced prolyl hydrox ...

Phaseolus vulgaris

Biochem. J.

229

693-699

1985

1

-

4

1

2

-

1

-

1

-

1

9

-

1

2

-

1

-

4

-

1

2

-

1

-

1

9

-

1

2

-

439226

De Waal

Photoaffinity labeling of pept ...

Gallus gallus

Biochemistry

24

6493-6499

1985

-

1

-

1

-

1

-

1

-

1

-

439192

De Jong

Stoicheiometry and kinetics of ...

Gallus gallus

Biochim. Biophys. Acta

787

105-111

1984

3

-

1

4

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

3

-

1

-

1

4

-

1

-

1

-

3

-

1

-

1

-

439193

Majamaa

The 2-oxoglutarate binding sit ...

Gallus gallus

Eur. J. Biochem.

138

239-245

1984

3

-

24

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

23

-

3

-

1

-

24

23

1

-

1

-

1

-

4

-

1

-

1

-

439219

Chrispeels

-

Prolyl hydroxylase in plants ...

Catharanthus roseus, Daucus carota, Lolium multiflorum

Methods Enzymol.

107

361-369

1984

2

-

2

3

-

3

-

1

-

12

1

-

2

-

4

-

2

-

4

-

2

-

2

3

-

1

-

12

1

-

2

-

439228

Turpeenniemi-Hujanen

Concomitant hydroxylation of p ...

Gallus gallus

Biochim. Biophys. Acta

800

59-65

1984

-

2

-

1

-

4

-

3

-

2

-

4

-

3

-

439231

Cohen

Biosynthesis of arabinogalacta ...

Lolium multiflorum

Plant Physiol.

72

754-758

1983

-

1

-

1

-

1

-

439149

Kivirikko

Posttranslational enzymes in t ...

Gallus gallus, Homo sapiens, Rattus norvegicus

Methods Enzymol.

82

245-304

1982

-

6

-

9

3

-

3

-

2

3

-

4

6

-

7

3

-

3

-

3

-

3

-

6

-

9

3

-

2

3

-

4

6

-

7

3

-

3

-

439195

De Jong

Prolyl 4-hydroxylase activity ...

Gallus gallus

Biochim. Biophys. Acta

704

326-332

1982

1

-

1

-

1

-

1

-

1

2

-

2

-

1

-

2

-

1

-

2

-

1

-

1

-

1

2

-

2

-

1

-

439230

Guzman

-

Prolyl 4-hydroxylase from huma ...

Gallus gallus

Coll. Relat. Res.

2

365-380

1982

-

1

-

1

-

1

-

1

-

1

-

439148

Kivirikko

-

The hydroxylation of prolyl an ...

Gallus gallus, Homo sapiens, Rattus norvegicus

Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York

1

53-104

1980

9

-

20

5

-

3

-

3

-

2

3

2

-

12

-

5

-

3

-

9

-

3

-

20

-

5

-

3

-

2

3

-

12

-

5

-

439196

Nietfeld

Properties of prolyl 4-hydroxy ...

Gallus gallus

Biochim. Biophys. Acta

613

349-358

1980

3

-

3

2

-

1

2

-

1

-

1

-

1

6

-

2

1

-

1

-

1

-

1

-

3

-

1

-

3

-

2

-

1

2

-

1

-

1

6

-

2

1

-

1

-

439220

Tanaka

A new prolyl hydroxylase actin ...

Catharanthus roseus

Biochim. Biophys. Acta

616

188-198

1980

2

-

6

2

3

1

-

3

-

1

-

1

-

3

6

-

1

-

3

-

2

-

3

-

6

-

2

3

1

-

1

-

1

-

3

6

-

1

-

439198

Takeda

Stimulation of prolyl hydroxyl ...

Rattus norvegicus

Arch. Biochem. Biophys.

197

273-276

1979

10

-

6

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

10

-

1

-

6

-

1

-

1

-

1

-

1

-

1

-

439199

Berg

Purification and partial chara ...

Gallus gallus

J. Biol. Chem.

254

3111-3118

1979

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

439200

Tryggvason

Prolyl 3-hydroxylase and 4-hyd ...

Gallus gallus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley

Biochem. J.

178

127-131

1979

-

164

-

20

-

3

-

2

-

20

-

3

-

2

-

439203

Leushner

-

Partial purification and chara ...

Panagrellus silusiae

Can. J. Zool.

56

159-165

1978

2

-

3

-

1

2

-

1

-

1

-

1

4

1

-

1

-

1

-

2

-

2

-

2

-

3

-

3

-

1

2

-

1

-

1

4

1

-

1

-

439201

Tryggvason

Separation of prolyl 3-hydroxy ...

Rattus norvegicus, Rattus norvegicus Sprague-Dawley

Biochem. Biophys. Res. Commun.

76

275-281

1977

-

1

-

163

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

4

-

1

-

439204

Tuderman

Tetramers and monomers of prol ...

Gallus gallus

Eur. J. Biochem.

78

547-556

1977

3

-

1

-

1

-

1

-

2

1

-

2

1

-

1

-

1

-

3

-

1

-

1

-

1

-

2

1

-

2

1

-

439205

Tuderman

Mechanism of the prolyl hydrox ...

Gallus gallus

Eur. J. Biochem.

80

341-348

1977

3

-

15

-

1

-

1

-

1

-

1

-

3

-

2

11

-

3

-

2

-

15

11

-

1

-

1

-

3

-

439206

Myllylä

Mechanism of the prolyl hydrox ...

Gallus gallus

Eur. J. Biochem.

80

349-357

1977

3

-

4

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

4

-

3

-

1

-

4

1

-

1

-

1

-

1

-

1

-

1

-

439223

Adams

Prolyl hydroxylase of earthwor ...

Lumbricus terrestris, Rattus norvegicus

J. Biol. Chem.

252

7591-7597

1977

4

-

2

-

2

-

1

-

2

-

8

-

4

-

4

-

4

-

2

-

1

-

2

-

8

-

439207

Guzman

Concanavalin A binds of purifi ...

Gallus gallus

Biochem. Biophys. Res. Commun.

73

279-285

1976

3

-

1

-

1

-

1

-

1

-

1

-

2

-

3

-

2

-

1

-

1

-

1

-

1

-

439208

Risteli

Intracellular enzymes of colla ...

Rattus norvegicus

Biochem. J.

158

369-376

1976

-

1

-

1

-

2

1

-

1

-

1

-

2

1

-

1

-

439209

Rapaka

Inhibition of hydroxyproline s ...

Gallus gallus

Biochim. Biophys. Acta

429

63-71

1976

-

3

-

2

-

2

-

1

-

1

-

3

1

-

2

-

1

-

439210

Tuderman

An affinity-column procedure u ...

Gallus gallus

Eur. J. Biochem.

52

9-16

1975

3

-

1

2

-

1

-

1

-

1

2

-

2

1

-

1

-

1

-

3

-

1

-

1

2

-

1

-

1

2

-

2

1

-

439211

Kuutti

Human prolyl hydroxylase. Puri ...

Homo sapiens

Eur. J. Biochem.

57

181-188

1975

-

3

-

1

-

1

-

2

-

2

1

-

3

-

1

-

2

-

2

1

-

439232

Rao

-

...

Lumbricus terrestris

Fed. Proc.

33

1535

1974

-

1

-

1

-

1

-

1

-

1

-

439212

Berg

Affinity column purification o ...

Gallus gallus

J. Biol. Chem.

248

1175-1182

1973

3

-

1

-

1

2

-

1

-

1

-

1

-

1

2

-

1

-

2

-

3

-

2

-

1

-

1

2

-

1

-

1

-

1

2

1

-

439222

Kuttan

Biochemistry of the hydroxypro ...

Daucus carota

Adv. Enzymol. Relat. Areas Mol. Biol.

37

273-347

1973

-

1

-

1

-

1

-

1

-

1

-

439235

Berg

Purification of (14C)-protocol ...

Gallus gallus

Biochemistry

12

3395-3401

1973

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

439213

McGee

Partial purification and chara ...

Mus musculus

Arch. Biochem. Biophys.

152

216-221

1972

-

2

-

2

-

1

-

2

-

2

-

2

-

1

-

2

-

2

-

439214

Kivirikko

Hydroxylation of (X-Pro-Gly)n ...

Gallus gallus

Biochim. Biophys. Acta

271

347-356

1972

3

-

1

-

1

-

1

-

7

-

1

-

2

-

3

-

2

-

1

-

1

-

7

-

1

-

439229

Cain

Protocollagen proline hydroxyl ...

Ascaris lumbricoides

Comp. Biochem. Physiol. B

40

165-179

1971

-

2

-

2

-

2

-

439215

Kivirikko

-

Purification and partial chara ...

Gallus gallus

Arch. Biochem. Biophys.

118

611-618

1967

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

-

1

-

1

-

1

-

2

-

1

-

439225

Hutton

-

Cofactor and substrate require ...

Cavia porcellus, Gallus gallus, Rattus norvegicus

Arch. Biochem. Biophys.

118

231-240

1967

-

27

3

-

5

-

3

-

3

-

3

-

9

-

9

-

27

-

3

-

5

-

3

-

3

-

Prolyl-4-hydroxylase alpha subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

Data extracted from this reference: