Cloned (Comment) | Organism |
---|---|
expressed in RPMI 1846 or CHO-K1/GalCerS cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the cell surface expression of GM4 detected by anti-GM4 antibody is markedly increased in RPMI 1846 cells upon transient transfection of the GM3/GM4S gene, phenotype, overview. Overexpression of the GM3/GM4S gene is required to express GM4 in RPMI 1846 cells | Mesocricetus auratus |
additional information | the expression of both the GalCer substrate and endogenous GM3/GM4S is not sufficient to induce GM4 expression in cultured cells. Overexpression of the GM3/GM4S gene is required to express GM4 in CHO-K1/GalCerS cells | Cricetulus griseus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Golgi apparatus | - |
Mus musculus | 5794 | - |
Golgi apparatus | the enzyme localizes to a compact juxtanuclear reticulum and partially colocalizes with GM130, a cis-Golgi marker protein | Homo sapiens | 5794 | - |
Golgi apparatus | the enzyme localizes to a compact juxtanuclear reticulum and partially colocalizes with GM130, a cis-Golgi marker protein | Mus musculus | 5794 | - |
Golgi apparatus | the enzyme localizes to a compact juxtanuclear reticulum and partially colocalizes with GM130, a cis-Golgi marker protein | Mesocricetus auratus | 5794 | - |
Golgi apparatus | the enzyme localizes to a compact juxtanuclear reticulum and partially colocalizes with GM130, a cis-Golgi marker protein | Cricetulus griseus | 5794 | - |
membrane | - |
Mus musculus | 16020 | - |
additional information | immunohistochemic analysis | Homo sapiens | - |
- |
additional information | immunohistochemic analysis | Mus musculus | - |
- |
additional information | immunohistochemic analysis | Mesocricetus auratus | - |
- |
additional information | immunohistochemic analysis | Cricetulus griseus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Homo sapiens | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Mus musculus | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Mesocricetus auratus | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Cricetulus griseus | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + galactosylceramide | Mus musculus | - |
CMP + ganglioside GM3 | - |
? | |
CMP-N-acetylneuraminate + lactosylceramide | Mus musculus | - |
CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | Homo sapiens | - |
CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | Mus musculus | - |
CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | Mesocricetus auratus | - |
CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | Cricetulus griseus | - |
CMP + ganglioside GM4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | Q80WL0 | a mutant lacking galactosylceramide synthase, gene ST3GAL5 | - |
Homo sapiens | Q9UNP4 | gene ST3GAL5 | - |
Mesocricetus auratus | Q9QXF5 | gene ST3GAL5 | - |
Mus musculus | - |
- |
- |
Mus musculus | O88829 | gene ST3GAL5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GM-95 cell | - |
Mus musculus | - |
HEK-293T cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
melanoma cell | - |
Mus musculus | - |
additional information | no enzyme activity in CHO-K1 ovary cells lacking or expressing galactosylceramide synthase. The expression of both the GalCer substrate and endogenous GM3/GM4S is not sufficient to induce GM4 expression in cultured cells | Cricetulus griseus | - |
additional information | no enzyme activity in RPMI 1846 melanoma cells | Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Homo sapiens | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Mus musculus | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Mesocricetus auratus | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Cricetulus griseus | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + galactosylceramide | - |
Mus musculus | CMP + ganglioside GM3 | - |
? | |
CMP-N-acetylneuraminate + lactosylceramide | - |
Mus musculus | CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | - |
Homo sapiens | CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | - |
Mus musculus | CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | - |
Mesocricetus auratus | CMP + ganglioside GM4 | - |
? | |
CMP-sialic acid + galactosylceramide | - |
Cricetulus griseus | CMP + ganglioside GM4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GM3/GM4S | - |
Mus musculus |
GM3/GM4S synthase | - |
Mus musculus |
GM3/GM4S synthase | - |
Homo sapiens |
GM3/GM4S synthase | - |
Mesocricetus auratus |
GM3/GM4S synthase | - |
Cricetulus griseus |
ST3Gal5 | - |
Mus musculus |
ST3Gal5 | - |
Homo sapiens |
ST3Gal5 | - |
Mesocricetus auratus |
ST3Gal5 | - |
Cricetulus griseus |