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Literature summary for 3.4.22.43 extracted from

  • Homma, T.; Kageyama, S.; Nishikawa, A.; Nagata, K.
    Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V (2018), Biochem. Biophys. Res. Commun., 500, 339-343 .
    View publication on PubMed
Search for more literature for 3.4.22.43

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of CTSV in keratinocytes. Inhibition of CTSV expression increases melanosome accumulation in HaCaT keratinocytes. The rate of melanosome degradation is reduced in CTSV knockdown keratinocytes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
melanosome
-
 Homo sapiens 42470
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60911 Japanese subjects
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
skin CTSV is highly expressed across the entire epidermis in normal skin. But CTSV expression levels are lower in the basal layer than those in the stratum corneum side in the hyperpigmented region Homo sapiens
-

Synonyms

Synonyms Comment Organism
cathepsin V
-
 Homo sapiens
CTSV
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction melanosome degradation is suppressed in CTSV knockdown cells. Inhibition of CTSV expression increases melanosome accumulation in HaCaT keratinocytes. The rate of melanosome degradation is reduced in CTSV knockdown keratinocytes Homo sapiens
physiological function enzyme cathepsin V (CTSV) is involved in melanosome degradation in the keratinocytes derived from lightcolored skin. It is one of the factors regulating pigmentation Homo sapiens