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Literature summary for 2.7.11.20 extracted from

  • Yu, P.; Wang, H.Y.; Tian, M.; Li, A.X.; Chen, X.S.; Wang, X.L.; Zhang, Y.; Cheng, Y.
    Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro (2019), Acta Pharmacol. Sin., 40, 1237-1244 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic elongation factor 2] Homo sapiens eukaryotic elongation factor 2 is inactivated when it is phosphorylated on Thr56 by the enzyme ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00418
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-
SK-MEL-5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic elongation factor 2] eukaryotic elongation factor 2 is inactivated when it is phosphorylated on Thr56 by the enzyme Homo sapiens ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
calmodulin-dependent protein kinase III
-
 Homo sapiens
EEF-2K
-
 Homo sapiens
eukaryotic elongation factor-2 kinase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens doxorubicin treatment activates the enzyme in the melanoma cells up

General Information

General Information Comment Organism
malfunction enzyme silencing blunts autophagic responses, but promotes doxorubicin-induced pyroptotic cell death in melanoma cells. Enzyme suppressionresults in inhibiting autophagy and augmenting pyroptosis, thus modulating the sensitivity of melanoma cells to doxorubicin Homo sapiens
physiological function the enzyme plays a the regulatory role of in pyroptosis in doxorubicin-treated human melanoma cells. The enzyme dictates the cross-talk between pyroptosis and autophagy in doxorubicin-treated human melanoma cells Homo sapiens