Cloned (Comment) | Organism |
---|---|
gene ST8SIA1, quantitative enzyme expression analysis, mRNA expressions of glycosyltransferases by qRT-PCR in melanocytes and melanoma lines, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + ganglioside GM3 | Homo sapiens | - |
CMP + ganglioside GD3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92185 | gene ST8SIA1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanocyte | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
MeWo cell | - |
Homo sapiens | - |
SK-MEL-23 cell | - |
Homo sapiens | - |
SK-MEL-28 cell | - |
Homo sapiens | - |
SK-MEL-37 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + ganglioside GM3 | - |
Homo sapiens | CMP + ganglioside GD3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ganglioside GD3 synthase | - |
Homo sapiens |
GD3 synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression levels are reduced after UVB irradiation in SK-MEL-28 melanoma cells | down |
Homo sapiens | GD3 synthase expression is induced by tumor necrosis factor alpha and interleukin 6 in melanocytes, except for SK-MEL-28 cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is part of the biosynthetic pathway of glycosphingolipids, overview | Homo sapiens |
additional information | direct UVB-irradiation of keratinocytes does not induces melanoma-associated ganglioside GD3 synthase gene in melanocytes, but UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor a and interleukin 6 | Homo sapiens |