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Literature summary for 1.13.11.53 extracted from

  • Bae, D.H.; Lane, D.J.R.; Siafakas, A.R.; Sutak, R.; Paluncic, J.; Huang, M.L.H.; Jansson, P.J.; Rahmanto, Y.S.; Richardson, D.R.
    Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone (2020), Biochim. Biophys. Acta Mol. Basis Dis., 1866, 165844 .
    View publication on PubMed
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Metals/Ions

Metals/Ions Comment Organism Structure
Iron the enzyme contains a non-heme, iron-binding site critical for its activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BV57
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
HaCaT cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-
SK-N-MC cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
acireductone dioxygenase 1
-
 Homo sapiens
ADI1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a significant decrease in enzyme mRNA levels is observed after 14 h of iron depletion. Silencing of the intracellular iron chaperone poly r(C)-binding protein 1 leads to loss of enzyme expression down