Literature summary for 2.1.1.366 extracted from

Orouji, E.; Federico, A.; Larribere, L.; Novak, D.; Lipka, D.B.; Assenov, Y.; Sachindra, S.; Hueser, L.; Granados, K.; Gebhardt, C.; Plass, C.; Umansky, V.; Utikal, J.
Histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target (2019), Int. J. Cancer, 145, 3462-3477.

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Application

Application	Comment	Organism
medicine	overexpression of SETDB1 contributes to melanoma tumorigenesis. SETDB1 is highly amplified in melanoma cells and in the patient tumors. Increased expression of SETDB1 correlates with SETDB1 amplification and is associated with a more aggressive phenotype in in vitro and in vivo studies. SETDB1 implements its effects via regulation of thrombospondin 1, and the SET-domain of SETDB1 is essential for the maintenance of its tumorigenic activity. Inhibition of SETDB1 reduces cell growth in melanomas resistant to targeted treatments	Homo sapiens
medicine	overexpression of SETDB1 contributes to melanoma tumorigenesis. SETDB1 is highly amplified in melanoma cells. Increased expression of SETDB1 correlates with SETDB1 amplification and is associated with a more aggressive phenotype in in vitro and in vivo studies. SETDB1 implements its effects via regulation of thrombospondin 1, and the SET-domain of SETDB1 is essential for the maintenance of its tumorigenic activity. Inhibition of SETDB1 reduces cell growth in melanomas resistant to targeted treatments	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15047	-	-
Mus musculus	O88974	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	-	Homo sapiens	-
melanoma cell	-	Mus musculus	-

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Release 2026.1 (March 2026)