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Literature summary for 5.3.99.2 extracted from

  • Omori, K.; Morikawa, T.; Kunita, A.; Nakamura, T.; Aritake, K.; Urade, Y.; Fukayama, M.; Murata, T.
    Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells (2018), J. Pathol., 244, 84-96 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
 Prostaglandin D2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F1 cell
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-
Lewis lung carcinoma cell
-
 Mus musculus
-
melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?

Synonyms

Synonyms Comment Organism
L-PGDS
-
 Mus musculus
lipocalin-type prostaglandin d synthase
-
 Mus musculus
PTGDS
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency accelerates the growth of melanoma in mice. Enzyme deficiency results in functional changes of tumor endothelial cells such as accelerated vascular hyperpermeability, angiogenesis, and endothelial-to-mesenchymal transition in tumors, which in turn reduce tumor cell apoptosis Mus musculus