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Information on EC 3.4.21.117 - stratum corneum chymotryptic enzyme

for references in articles please use BRENDA:EC3.4.21.117

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IUBMB Comments

This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the α-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6┼Cya7, Tyr16┼Leu17, Phe25┼Tyr26 and Tyr26┼Thr27 . It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
cleavage of proteins with aromatic side chains in the P1 position

Synonyms
kallikrein 7, stratum corneum chymotryptic enzyme, kallikrein-related peptidase 7, kallikrein-7, tissue kallikrein 7, human stratum corneum chymotryptic enzyme, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cleavage of proteins with aromatic side chains in the P1 position
show the reaction diagram