EC Number   |
Recommended Name |
Source Tissue |
Reference |
|---|
   4.6.1.2 | guanylate cyclase |
heart |
at both tissue and single myocyte levels, sGC protein expression is heterogeneous, being high in sinoatrial node, right atrium, right ventricle and left ventricular subepicardium, but markedly reduced to absent in left atrium and left ventricular subendocardium |
691727 |
| 4.6.1.2 | guanylate cyclase |
heart |
from lean and obese rats, enzyme localization at left ventricle and coronary arteriole |
690358 |
| 4.6.1.2 | guanylate cyclase |
heart |
isozymes GC-A |
692548 |
| 4.6.1.6 | cytidylate cyclase |
heart |
- |
-, 648785, 648786, 648790, 648792 |
 4.98.1.1 | protoporphyrin ferrochelatase |
heart |
- |
34936 |
| 5.1.1.13 | aspartate racemase |
heart |
- |
706558 |
| 5.1.1.13 | aspartate racemase |
heart |
high expression level |
728034 |
| 5.1.1.18 | serine racemase |
heart |
- |
747888 |
| 5.1.1.18 | serine racemase |
heart |
peripheral expression in cardiac myocyte |
661409 |
| 5.1.99.4 | alpha-methylacyl-CoA racemase |
heart |
weak |
2449 |
| 5.3.1.21 | corticosteroid side-chain-isomerase |
heart |
- |
2655 |
| 5.3.1.6 | ribose-5-phosphate isomerase |
heart |
two electrophorectic forms |
2777 |
| 5.3.1.8 | mannose-6-phosphate isomerase |
heart |
- |
2826 |
| 5.3.1.9 | glucose-6-phosphate isomerase |
heart |
- |
2838, 2851 |
| 5.3.2.1 | phenylpyruvate tautomerase |
heart |
- |
2868 |
| 5.3.2.2 | oxaloacetate tautomerase |
heart |
- |
2877, 2878, 2879, 2880 |
| 5.3.3.12 | L-dopachrome isomerase |
heart |
- |
727347 |
| 5.3.3.21 | DELTA3,5-DELTA2,4-dienoyl-CoA isomerase |
heart |
- |
745267 |
| 5.3.3.3 | vinylacetyl-CoA DELTA-isomerase |
heart |
- |
2960 |
| 5.3.3.8 | DELTA3-DELTA2-enoyl-CoA isomerase |
heart |
- |
3002, 3009, 3014, 3019 |
| 5.3.4.1 | protein disulfide-isomerase |
heart |
- |
3049, 701629 |
| 5.3.4.1 | protein disulfide-isomerase |
heart |
activities in adult tissues are only 10-40% of those found in newborn |
3049 |
| 5.3.99.2 | Prostaglandin-D synthase |
heart |
- |
702057 |
| 5.3.99.3 | prostaglandin-E synthase |
heart |
- |
3134, 661310, 690714, 693551, 694942 |
| 5.3.99.3 | prostaglandin-E synthase |
heart |
faint expression levels |
661310 |
| 5.3.99.3 | prostaglandin-E synthase |
heart |
mPEGS-2 |
667830 |
| 5.3.99.5 | thromboxane-A synthase |
heart |
low activity |
3183 |
| 5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
heart |
- |
3248, 703862 |
| 5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
heart |
in early fetal life PGAM-BB is the only isozyme present in all tissues, in myogenesis these phenotypes undergo transition to MM-type via an MB-hybrid, all isozymes are present in mature heart tissue, enzyme activity increases with administration of 3,3'-triiodo-D-thyronine to the animal |
3227 |
| 5.4.3.7 | leucine 2,3-aminomutase |
heart |
- |
3413, 3415, 3416 |
| 5.4.99.B22 | multisite-specific tRNA pseudouridine synthase |
heart |
- |
660654 |
| 5.5.1.4 | inositol-3-phosphate synthase |
heart |
- |
746709 |
| 5.5.1.4 | inositol-3-phosphate synthase |
heart |
low expression |
704640 |
| 5.6.1.1 | microtubule-severing ATPase |
heart |
- |
675537, 699690 |
| 5.6.1.1 | microtubule-severing ATPase |
heart |
lower levels of spastin expression compared with neuronal tissues |
699690 |
| 5.6.1.3 | plus-end-directed kinesin ATPase |
heart |
- |
210549 |
| 5.6.1.5 | proteasome ATPase |
heart |
- |
688447 |
| 5.6.1.6 | channel-conductance-controlling ATPase |
heart |
- |
675628 |
| 5.6.1.8 | myosin ATPase |
heart |
- |
751816 |
| 5.6.1.8 | myosin ATPase |
heart |
conduction system and ventricular tissue |
246994 |
| 5.6.1.8 | myosin ATPase |
heart |
fibres from papillary muscle |
699785 |
| 5.6.1.8 | myosin ATPase |
heart |
left ventricular myocardium |
655279 |
| 5.6.1.8 | myosin ATPase |
heart |
left ventricular myofibril |
656780 |
| 5.6.2.3 | DNA 5'-3' helicase |
heart |
- |
756521 |
| 6.1.1.11 | serine-tRNA ligase |
heart |
high expression |
660869 |
| 6.1.1.12 | aspartate-tRNA ligase |
heart |
- |
744436 |
| 6.1.1.2 | tryptophan-tRNA ligase |
heart |
- |
288 |
| 6.1.1.2 | tryptophan-tRNA ligase |
heart |
about 0.02% of total soluble protein |
306 |
| 6.1.1.20 | phenylalanine-tRNA ligase |
heart |
- |
649540 |
| 6.1.1.21 | histidine-tRNA ligase |
heart |
- |
745301 |
| 6.1.1.4 | leucine-tRNA ligase |
heart |
- |
693987 |
| 6.2.1.1 | acetate-CoA ligase |
heart |
- |
563, 567, 570, 572 |
| 6.2.1.1 | acetate-CoA ligase |
heart |
AceCS2, high activity |
652101 |
| 6.2.1.2 | medium-chain acyl-CoA ligase |
heart |
- |
675, 677 |
| 6.2.1.24 | phytanate-CoA ligase |
heart |
- |
702 |
| 6.2.1.3 | long-chain-fatty-acid-CoA ligase |
heart |
- |
649789, 671244, 671335, 672421, 733, 756 |
| 6.2.1.3 | long-chain-fatty-acid-CoA ligase |
heart |
highly expressed in vascular endothelium |
650399 |
| 6.2.1.4 | succinate-CoA ligase (GDP-forming) |
heart |
- |
652820, 662256, 727203, 744272, 785, 787, 789, 793 |
| 6.2.1.4 | succinate-CoA ligase (GDP-forming) |
heart |
newborn and adult |
794 |
| 6.2.1.5 | succinate-CoA ligase (ADP-forming) |
heart |
- |
702332, 744272, 799, 803 |
| 6.2.1.5 | succinate-CoA ligase (ADP-forming) |
heart |
high level |
693488 |
| 6.2.1.6 | glutarate-CoA ligase |
heart |
- |
828 |
| 6.3.1.2 | glutamine synthetase |
heart |
- |
37496, 691904 |
| 6.3.2.11 | carnosine synthase |
heart |
- |
744004, 988, 989, 995 |
| 6.3.2.18 | gamma-glutamylhistamine synthase |
heart |
less than 10% enzyme activity in heart compared to ganglia |
1102 |
| 6.3.2.2 | glutamate-cysteine ligase |
heart |
- |
649263, 672367, 692058 |
| 6.3.2.25 | tubulin-tyrosine ligase |
heart |
- |
663250 |
| 6.3.2.3 | glutathione synthase |
heart |
- |
691925, 705634 |
| 6.3.2.41 | N-acetylaspartylglutamate synthase |
heart |
very low expression |
727869 |
| 6.3.2.61 | tubulin-glutamate ligase |
heart |
- |
763305 |
| 6.3.3.2 | 5-formyltetrahydrofolate cyclo-ligase |
heart |
low enzyme expression |
652430 |
| 6.3.4.21 | nicotinate phosphoribosyltransferase |
heart |
- |
-, 637754, 680797 |
| 6.3.4.21 | nicotinate phosphoribosyltransferase |
heart |
1.9 kb mRNA detected by Northern blot analysis, moderate expression |
-, 680797 |
| 6.3.4.21 | nicotinate phosphoribosyltransferase |
heart |
significant endogenous activity |
680797 |
| 6.3.4.4 | adenylosuccinate synthase |
heart |
- |
1537, 1543, 673163 |
| 6.3.4.4 | adenylosuccinate synthase |
heart |
weak expression level of ADSS2 mRNA |
673163 |
| 6.3.5.1 | NAD+ synthase (glutamine-hydrolysing) |
heart |
- |
1627 |
| 6.3.5.1 | NAD+ synthase (glutamine-hydrolysing) |
heart |
the major sites of NADsyn1 gene expression are the small intestine, kidney, liver, and testis, whereas the skeletal muscle, spleen, lung, heart, and brain show a weak signal |
652364 |
| 6.3.5.2 | GMP synthase (glutamine-hydrolysing) |
heart |
- |
1354, 1384 |
| 6.3.5.3 | phosphoribosylformylglycinamidine synthase |
heart |
- |
1664 |
| 6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) |
heart |
- |
1743 |
| 6.4.1.1 | pyruvate carboxylase |
heart |
moderate activity |
649667 |
| 6.4.1.2 | acetyl-CoA carboxylase |
heart |
- |
37599, 664193, 671950, 675028, 702619 |
| 6.4.1.2 | acetyl-CoA carboxylase |
heart |
isozyme Acc2 |
664193, 664564 |
| 6.4.1.3 | propionyl-CoA carboxylase |
heart |
- |
1870 |
| 6.4.1.4 | methylcrotonoyl-CoA carboxylase |
heart |
only trace levels |
662759 |
| 7.1.1.1 | proton-translocating NAD(P)+ transhydrogenase |
heart |
- |
764052, 764194 |
| 7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
heart |
- |
391082, 392676, 392684, 392691, 392692, 392699, 392703, 392717, 392718, 392721, 658174, 658265, 659106, 659108, 659109, 659946, 671827, 671882, 671993, 672013, 672126, 672176, 672291, 672348, 672597, 674694, 676868, 690886, 691037, 696270, 696312, 696510, 696745, 707505, 711290, 714281, 714993, 724252, 724383, 724564, 725002, 725003, 725491, 741606, 743263 |
| 7.1.1.8 | quinol-cytochrome-c reductase |
heart |
- |
395300, 396001, 439942, 439943, 439944, 439945, 439946, 439947, 439948, 439950, 439952, 439953, 439955, 439956, 439958, 439960, 439961, 439962, 439964, 439966, 439967, 439970, 439975, 439980, 439983, 439985, 439986, 439988, 439989, 439990, 439991, 439993, 440000, 440003, 440006, 440009, 440012, 440016, 440018, 440023, 440025, 440026, 440027, 440028, 440029, 440030, 440035, 657683, 658009, 658165, 658674, 659673, 672379, 696100, 724452, 725396, 742055 |
| 7.1.1.8 | quinol-cytochrome-c reductase |
heart |
heart muscle |
439944 |
| 7.1.1.8 | quinol-cytochrome-c reductase |
heart |
highly expressed in heart, the expression increases in hearts of 4-, 10-, and 28-week-old spontaneously hypertensive rats. UCCR7.2 expression is reduced in the absence of ovarian hormones, but is not directly regulated by estrogen in the heart. UCCR7.2 is a steroid hormone-responsive gene in the heart, with expression increased in cardiac hypertrophy and in response to hypertension |
685905 |
| 7.1.1.8 | quinol-cytochrome-c reductase |
heart |
Keilin-Hartree muscle preparation |
439957 |
| 7.1.1.9 | cytochrome-c oxidase |
heart |
- |
395999, 396016, 396019, 396028, 396033, 396035, 396037, 396039, 396040, 396041, 396043, 396049, 396052, 396055, 396058, 396063, 396064, 396065, 396067, 396077, 396080, 396083, 396084, 396092, 396104, 396117, 396118, 396121, 396126, 657655, 658173, 658620, 659582, 673702, 676865, 686054, 690359, 691023, 691038, 691404, 691758, 693006, 693787, 694175, 695076, 711289, 741541, 742002, 742031, 743264, 752934, 755271 |
| 7.1.1.9 | cytochrome-c oxidase |
heart |
downregulation of enzyme activity in the neonatal period by factor 3 |
672953 |
| 7.1.1.9 | cytochrome-c oxidase |
heart |
thyroid hormone T3 has no effect on COX Vb expression |
657516 |
| 7.1.2.2 | H+-transporting two-sector ATPase |
heart |
- |
210232, 210233, 210237, 210239, 210244, 210245, 210249, 210264, 671243, 672313, 673318, 696051, 698676, 711328, 712401, 720931 |
| 7.1.2.2 | H+-transporting two-sector ATPase |
heart |
healthy and ischemic |
698308 |
| 7.2.2.10 | P-type Ca2+ transporter |
heart |
- |
210479, 210482, 210485, 670757, 695858, 697167, 718751, 720121, 733277, 733416, 734372, 750281, 751396 |
| 7.2.2.10 | P-type Ca2+ transporter |
heart |
methods to employ tissue homogenates to study sarcoplasmatic reticulum Ca2+ transport function in individual mouse hearts |
210494 |
| 7.2.2.10 | P-type Ca2+ transporter |
heart |
PMCA2 is expressed at a lower level in the heart |
695858 |
