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Aspartate--tRNA ligase
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Aspartyl ribonucleate synthetase
Aspartyl ribonucleic synthetase
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aspartyl ribonuleic synthetase
Aspartyl-transfer ribonucleic acid synthetase
Aspartyl-transfer RNA synthetase
cytoplasmic aspartyl-tRNA synthetase
discriminating aspartyl-tRNA synthetase
mitochondrial aspartyl-tRNA synthetase
non-discriminating aspartyl-tRNA synthetase
Synthetase, aspartyl-transfer ribonucleate
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AsnRS
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartic acid translase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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Aspartyl ribonucleate synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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aspartyl ribonuleic synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer ribonucleic acid synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-transfer RNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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Aspartyl-tRNA synthetase
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AspRS
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AspS
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cytoplasmic aspartyl-tRNA synthetase
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cytoplasmic aspartyl-tRNA synthetase
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discriminating aspartyl-tRNA synthetase
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discriminating aspartyl-tRNA synthetase
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DRS
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mitochondrial aspartyl-tRNA synthetase
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mitochondrial aspartyl-tRNA synthetase
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non-discriminating aspartyl-tRNA synthetase
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non-discriminating aspartyl-tRNA synthetase
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non-discriminating AspRS
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non-discriminating AspRS
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
mechanism
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
active site structure
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
active site residues
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
Asn binding sites K198 and H449, binding mechanism and free energies
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
conserved amino acid residues of functional importance in consensus motifs: Pro227 in motif 1, Arg332 and Glu334 in motif 2, Gly675, Gly679, Asp681, Arg682, and Pro700 in motif 3
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
conserved amino acid residues of functional importance in consensus motifs: Pro227 in motif 1, Arg332 and Glu334 in motif 2, Gly675, Gly679, Glu681, Arg682, and Pro700 in motif 3
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
determination of structural features for discriminating or nondiscriminating aminoacylation activity
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
determination of structural features for discriminating or nondiscriminating aminoacylation activity
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
mechanism, active site structure, substrate binding, simulations of binding and free energy
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
mechanism, active site structure, substrate binding, simulations of binding and free energy
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
mechanism, active site structure, substrate binding, simulations of binding and free energy, protein-ligand modeling
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
pathway for tRNA binding and recognition is proposed
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
protein-RNA recognition mechanism, backbone interactions are an important functional component of the tRNA synthetase interaction
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
RNA-binding motif XSKXXLKKXK
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
active site structure, AspRS substrate recognition and chiral specificity of wild-type enzyme and mutant Q199E, substrate binding in regular versus inverted orientation, overview
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
active site structure, ligand and substrate binding, and reaction mechanism
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
conserved amino acid residues of functional importance in consensus motifs: Pro227 in motif 1, Arg332 and Glu334 in motif 2, Gly675, Gly679, Asp681, Arg682, and Pro700 in motif 3
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ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp
conserved amino acid residues of functional importance in consensus motifs: Pro227 in motif 1, Arg332 and Glu334 in motif 2, Gly675, Gly679, Glu681, Arg682, and Pro700 in motif 3
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adenosine 5-[beta,gamma-imido]-triphosphate + L-Asp
AMP-Asp + imidodiphosphate
AMP-Asp + diphosphate
ATP + L-Asp
ATP + 2-aminomalonic acid + tRNAAsp
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ATP + Asp + tRNAAsn
AMP + diphosphate + aspartyl-tRNAAsn
discriminating AspRS gains the ability to form Asp-tRNAAsn in vitro when the W26H or K85P changes are introduced independently or in combination
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?
ATP + Asp + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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ATP + D-aspartate + tRNAAsp
AMP + diphosphate + D-aspartyl-tRNAAsp
aspartyl-tRNA synthetase can misacylate tRNAAsp with D-aspartate instead of its usual substrate, L-Asp, substrate specificity and molecular dynamics simulations, overview
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ATP + L-Asp + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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low reaction with mutant tRNAAsp with A instead of G at position 73 (tRNAAspA73)
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?
ATP + L-asparagine + tRNAAsp
AMP + diphosphate + L-asparaginyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsp
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
ATP + L-aspartate + tRNAAspA73
AMP + diphosphate + L-aspartyl-tRNAAspA73
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ATP + threo-3-hydroxyaspartic acid + tRNAAsp
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GTP + L-aspartate + tRNAAsp
GMP + diphosphate + L-aspartyl-tRNAAsp
UTP + L-aspartate + tRNAAsp
UMP + diphosphate + L-aspartyl-tRNAAsp
additional information
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adenosine 5-[beta,gamma-imido]-triphosphate + L-Asp
AMP-Asp + imidodiphosphate
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adenosine 5-[beta,gamma-imido]-triphosphate + L-Asp
AMP-Asp + imidodiphosphate
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AMP-Asp + diphosphate
ATP + L-Asp
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AMP-Asp + diphosphate
ATP + L-Asp
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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the archaeal AspRS enzyme is nondiscriminating, which means that it forms Asp-tRNAAsp and Asp-tRNAAsn, which is the intermediate in AsntRNAAsn generation by ASp-tRNAAsn amidotransferase, in contrary bacterial enzymes are discriminating ones
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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the archaeal AspRS2 enzyme is discriminating, which means that it forms only Asp-tRNAAsp and not Asp-tRNAAsn, the L1 loop exchange mutant is rendered non-dicriminating
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
wild-type enzyme shows no activity with tRNAAsn. Mutant enzymes W26H, K85P and W26H/K85P are active with tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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the archaeal AspRS2 enzyme is nondiscriminating, which means that it forms Asp-tRNAAsp and Asp-tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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non-discriminating AspRS2
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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non-discriminating AspRS2, recombinantly produced tRNAAsn
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsn
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non-discriminating AspRS2
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsp
about half as effective as tRNAAsp
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsp
about have as effective as tRNAAsp
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsp
about half as effective as tRNAAsp
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ATP + L-aspartate + tRNAAsn
AMP + diphosphate + L-aspartyl-tRNAAsp
about have as effective as tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + aspartyl-tRNAAsp
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enzyme deficiency or mutation is involved in development of autosomal recessive disease leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation, i.e. LBSL, often manifesting in early childhood, overview
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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conformational changes and conformational stability upon tRNA and adenylate binding
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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wild-type Escherichia coli tRNAAsp and some recombinant acceptor stem mutants from Saccharomyces cerevisiae, overview
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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protein-RNA recognition between the enzyme and tRNA is highly specific and essential for cell viability
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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specific amino acid binding by the enzyme is required for correct translation of the genetic code
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
aspartyl-tRNA synthetase can misacylate tRNAAsp with D-aspartate instead of its usual substrate, L-Asp, substrate specificity and molecular dynamics simulations, overview
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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no activity with tRNAAsn
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
ATP + L-aspartate + tRNAAsp
AMP + diphosphate + L-aspartyl-tRNAAsp
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?
6.1.1.12 aspartate-tRNA ligase
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