Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.5.2 extracted from

  • Hirai, K.; Matsuda, Y.; Nakagawa, H.
    Purification and characterization of GMP synthetase from Yoshida sarcoma ascites cells (1987), J. Biochem., 102, 893-902.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
reduced sulfhydryl compounds e.g. dithiothreitol, required Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
Rattus norvegicus
cAMP
-
Rattus norvegicus
cGMP
-
Rattus norvegicus
CMP
-
Rattus norvegicus
GMP
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
XMP
-
Rattus norvegicus
0.12
-
ATP
-
Rattus norvegicus
0.3
-
Gln
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Yoshida sarcoma ascites cells Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ high activity only in presence of Mg2+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Yoshida sarcoma ascites cells Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
intestine
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
ovary
-
Rattus norvegicus
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-
Yoshida ascites sarcoma cell
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.22
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + XMP + Gln maximal activity with NH4+ is 80% of that obtained with Gln Rattus norvegicus AMP + diphosphate + GMP + Glu
-
?
ATP + XMP + Gln higher Km value for NH4+ compared with Gln Rattus norvegicus AMP + diphosphate + GMP + Glu
-
?
ATP + XMP + NH4+ maximal activity with NH4+ is 80% of that obtained with Gln Rattus norvegicus AMP + diphosphate + GMP
-
?
ATP + XMP + NH4+ higher Km value for NH4+ compared with Gln Rattus norvegicus AMP + diphosphate + GMP
-
?

Subunits

Subunits Comment Organism
monomer 1 * 78000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 more than 50% of maximal activity at pH 6.5 and pH 9.0 Rattus norvegicus