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Information on EC 6.3.4.4 - adenylosuccinate synthase
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6.3.4.4 adenylosuccinate synthaseSpecify your search results
Word Map
- 6.3.4.4
- purine
- gtp
- inosine
- hadacidin
- hypoxanthine
- formycin
- adenylosuccinase
-
alanosine
- medicine
-
saicar
- synthesis
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
adenylosuccinate synthetase, adssl1, adss1, adenylosuccinate synthase, pfadss, adss2, ampss, succino-amp synthetase, adenylosuccinate synthetase 1, mouse muscle synthetase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosylsuccinate synthetase
adenylo-succinate synthetase
Adenylosuccinate synthase
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Adenylosuccinate synthetase
AdSS
AdSS1
AdSS2
AMPSase
ASS
IMP--aspartate ligase
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IMP-aspartate ligase
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PfAdSS
purA
Succino-AMP synthetase
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Succinoadenylic kinosynthetase
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Adenylosuccinate synthetase
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AdSS
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AMPSase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
fully random mechanism
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
sequential rapid equilibrium fully random mechanism
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
fully random terter mechanism
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
random sequential binding mechanism
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
phosphate-binding region of adenylosuccinate synthetase is involved in a conformational change induced by GTP and IMP binding. GTP and IMP binding depend on the presence of the other substrate at the active site of the enzyme
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
sequential mechanism with a fully random order of substrate addition
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
rapid equilibrium random AB steady-state ordered C kinetic mechanism
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
rapid equilibrium random AB steady-state ordered C kinetic mechanism
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GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amination
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
IMP:L-aspartate ligase (GDP-forming)
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CAS REGISTRY NUMBER
COMMENTARY
9023-57-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-dGTP + IMP + L-aspartate
2'-dGDP + phosphate + adenylosuccinate
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?
ddGTP + IMP + L-aspartate
ddGDP + phosphate + adenylosuccinate
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?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
GTP + IMP + Ala-3-nitronate
GDP + phosphate + N6-(L-1-carboxy-2-nitroethyl)AMP
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-
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?
ITP + IMP + L-aspartate
IDP + phosphate + adenylosuccinate
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?
GTP + 2'-dIMP + L-Asp
GDP + phosphate + 2'-deoxysuccinoAMP
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61% of the efficiency of IMP as substrate, V/Km
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?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
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?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
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?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
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i.e. allopurinol ribonucleotide
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?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
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?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
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?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
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?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
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?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
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8.8% of the efficiency of IMP as substrate , V/Km
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?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
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?
GTP + IMP + L-Asp
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penultimate step in pathway of AMP biosynthesis
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?
GTP + IMP + L-Asp
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plays an important role in the interconversion of purines
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?
GTP + IMP + L-Asp
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plays an important role in the interconversion of purines
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?
GTP + IMP + L-Asp
?
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first committed step towards the de novo biosynthesis of AMP
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?
GTP + IMP + L-Asp
?
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first committed step towards the de novo biosynthesis of AMP
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?
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
catalyzing the first step in the de novo synthesis of adenylmonophosphate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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catalyzes the first step in the conversion of IMP to AMP in de novo purine nucleotide metabolism
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
catalyzing the first committed step in de novo biosynthesis of AMP
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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catalyzing the first committed step in the biosynthesis of AMP
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from L-aspartate and IMP
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
governs the first committed step in de novo biosynthesis of AMP plays a significant role in de novo purine nucleotide biosynthesis, the purine nucleotide cycle, and/or salvage pathway for nucleotides
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
first committed step in AMP synthesis. Isoenzyme AdSS1 has a potential role in muscle metabolism
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?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
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?