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McNally, F.J.; Vale, R.D.
Identification of katanin, an ATPase that severs and disassembles stable microtubules
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Actinocoryne sp., Chlamydomonas reinhardtii, Spisula solidissima, Strongylocentrotus purpuratus, Xenopus laevis
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Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit
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Saccharomyces cerevisiae, Caenorhabditis elegans, Dictyostelium sp., Drosophila sp. (in: flies), Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
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Cloning of Chlamydomonas p60 katanin and localization to the site of outer doublet severing during deflagellation
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MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C. elegans
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PF15p is the Chlamydomonas homologue of the katanin p80 subunit and is required for assembly of flagellar central microtubules
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Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules
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Rattus norvegicus (Q6E0V2)
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The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules
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Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis
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Meiotic spindle: sculpted by severing
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Caenorhabditis elegans
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Regulation of chondrocyte differentiation by actin-severing protein adseverin
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Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration
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Mus musculus
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The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
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Danio rerio (Q6NW58), Danio rerio
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Homo sapiens
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Homo sapiens (Q9UBP0), Homo sapiens
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The Caenorhabditis elegans microtubule-severing complex MEI-1/MEI-2 katanin interacts differently with two superficially redundant beta-tubulin isotypes
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Caenorhabditis elegans
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Unexpected pathogenic mechanism of a novel mutation in the coding sequence of SPG4 (spastin)
Neurology
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Katanins severing activity favors bundling of cortical microtubules in plants
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Arabidopsis thaliana
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Analysis of the rice mutant dwarf and gladius leaf 1. Aberrant katanin-mediated microtubule organization causes up-regulation of gibberellin biosynthetic genes independently of gibberellin signaling
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Homo sapiens
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The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules
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Caenorhabditis elegans
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Conformation-dependent ligand regulation of ATP hydrolysis by human KSP - activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator
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Homo sapiens
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Homo sapiens
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Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule
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Homo sapiens
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Spastin and microtubules - Functions in health and disease
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Homo sapiens (Q9UBP0)
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Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
Nature
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Drosophila melanogaster (Q8I0P1)
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Mannan, A.U.; Boehm, J.; Sauter, S.M.; Rauber, A.; Byrne, P.C.; Neesen, J.; Engel, W.
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein
Neurogenetics
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Homo sapiens
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Arabidopsis katanin binds microtubules using a multimeric microtubule-binding domain
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Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana
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Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia
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Rattus norvegicus
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The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches
Mol. Biol. Cell
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Rattus norvegicus
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Connell, J.W.; Lindon, C.; Luzio, J.P.; Reid, E.
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion
Traffic
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Homo sapiens (Q9UBP0)
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Matsushita-Ishiodori, Y.; Yamanaka, K.; Hashimoto, H.; Esaki, M.; Ogura, T.
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing
Genes Cells
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Caenorhabditis elegans
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Iwaya, N.; Kuwahara, Y.; Fujiwara, Y.; Goda, N.; Tenno, T.; Akiyama, K.; Mase, S.; Tochio, H.; Ikegami, T.; Shirakawa, M.; Hiroaki, H.
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization
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Mus musculus
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Zhang, D.; Grode, K.D.; Stewman, S.F.; Diaz-Valencia, J.D.; Liebling, E.; Rath, U.; Riera, T.; Currie, J.D.; Buster, D.W.; Asenjo, A.B.; Sosa, H.J.; Ross, J.L.; Ma, A.; Rogers, S.L.; Sharp, D.J.
Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration
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Drosophila melanogaster
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Lumb, J.H.; Connell, J.W.; Allison, R.; Reid, E.
The AAA ATPase spastin links microtubule severing to membrane modelling
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Homo sapiens
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Iwaya, N.; Akiyama, K.; Goda, N.; Tenno, T.; Fujiwara, Y.; Hamada, D.; Ikura, T.; Shirakawa, M.; Hiroaki, H.
Effect of Ca2+ on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanism
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Mus musculus (Q9WV86)
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Eckert, T.; Link, S.; Le, D.T.; Sobczak, J.P.; Gieseke, A.; Richter, K.; Woehlke, G.
Subunit interactions and cooperativity in the microtubule-severing AAA ATPase spastin
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Homo sapiens
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Draberova, E.; Vinopal, S.; Morfini, G.; Liu, P.S.; Sladkova, V.; Sulimenko, T.; Burns, M.R.; Solowska, J.; Kulandaivel, K.; de Chadarevian, J.P.; Legido, A.; Moerk, S.J.; Janacek, J.; Baas, P.W.; Draber, P.; Katsetos, C.D.
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
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Homo sapiens (Q9UBP0), Homo sapiens
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Homo sapiens
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Caenorhabditis elegans (Q8MNV0), Caenorhabditis elegans
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McNally, K.; Berg, E.; Cortes, D.B.; Hernandez, V.; Mains, P.E.; McNally, F.J.
Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro
Mol. Biol. Cell
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Caenorhabditis elegans
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Matsuo, M.; Shimodaira, T.; Kasama, T.; Hata, Y.; Echigo, A.; Okabe, M.; Arai, K.; Makino, Y.; Niwa, S.; Saya, H.; Kishimoto, T.
Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells
PLoS ONE
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Rattus norvegicus (Q6E0V2)
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Bailey, M.E.; Sackett, D.L.; Ross, J.L.
Katanin severing and binding microtubules are inhibited by tubulin carboxy tails
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Homo sapiens (O75449), Homo sapiens, Xenopus laevis (Q9PUL2)
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Joly, N.; Martino, L.; Gigant, E.; Dumont, J.; Pintard, L.
Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly
Development
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2016
Caenorhabditis elegans (P34808), Caenorhabditis elegans
brenda
Fan, X.; Lin, Z.; Fan, G.; Lu, J.; Hou, Y.; Habai, G.; Sun, L.; Yu, P.; Shen, Y.; Wen, M.; Wang, C.
The AAA protein spastin possesses two levels of basal ATPase activity
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Homo sapiens (Q9UBP0)
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Luptovciak, I.; Samakovli, D.; Komis, G.; Samaj, J.
KATANIN 1 is essential for embryogenesis and seed formation in Arabidopsis
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Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana ecotype Columbia (Q9SEX2)
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Nithianantham, S.; McNally, F.J.; Al-Bassam, J.
Structural basis for disassembly of katanin heterododecamers
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Caenorhabditis elegans (P34808), Homo sapiens (Q9BW62)
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Cheung, K.; Senese, S.; Kuang, J.; Bui, N.; Ongpipattanakul, C.; Gholkar, A.; Cohn, W.; Capri, J.; Whitelegge, J.P.; Torres, J.Z.
Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing
Mol. Cell. Proteomics
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Homo sapiens (Q9BW62)
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Waclawek, E.; Joachimiak, E.; Hall, M.H.; Fabczak, H.; Wloga, D.
Regulation of katanin activity in the ciliate Tetrahymena thermophila
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Tetrahymena thermophila, Tetrahymena thermophila CU428.2
brenda
Grode, K.D.; Rogers, S.L.
The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity
PLoS ONE
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2015
Drosophila melanogaster (Q9VN89)
brenda
Abu-Abied, M.; Mordehaev, I.; Sunil Kumar, G.B.; Ophir, R.; Wasteneys, G.O.; Sadot, E.
Analysis of microtubule-associated-proteins during IBA-mediated adventitious root induction reveals KATANIN dependent and independent aterations of expression patterns
PLoS ONE
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2015
Arabidopsis thaliana (Q9SEX2), Arabidopsis thaliana ecotype Columbia (Q9SEX2)
brenda
Rezabkova, L.; Jiang, K.; Capitani, G.; Prota, A.E.; Akhmanova, A.; Steinmetz, M.O.; Kammerer, R.A.
Structural basis of katanin p60 p80 complex formation
Sci. Rep.
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Mus musculus (Q9WV86 AND Q8BG40)
brenda
Jiang, K.; Faltova, L.; Hua, S.; Capitani, G.; Prota, A.E.; Landgraf, C.; Volkmer, R.; Kammerer, R.A.; Steinmetz, M.O.; Akhmanova, A.
Structural basis of formation of the microtubule minus-end-regulating CAMSAP-Katanin complex
Structure
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2018
Mus musculus
brenda