Cloned (Comment) | Organism |
---|---|
isozyme GC-A | Homo sapiens |
isozyme GC-B | Homo sapiens |
isozyme GC-C | Homo sapiens |
isozyme GC-F | Homo sapiens |
isozymes GC-A to GC-G | Mus musculus |
isozymes GC-D, GC-E, to GC-G | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | membrane guanylyl cyclase receptor isozyme GC-A | Homo sapiens | 5886 | - |
plasma membrane | membrane guanylyl cyclase receptor isozyme GC-B | Homo sapiens | 5886 | - |
plasma membrane | membrane guanylyl cyclase receptor isozyme GC-C | Homo sapiens | 5886 | - |
plasma membrane | membrane guanylyl cyclase receptor isozymes GC-D, GC-E, to GC-G | Homo sapiens | 5886 | - |
plasma membrane | several membrane guanylyl cyclase receptor isozymes, GC-A to GC-G | Mus musculus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | guanylyl cyclase receptors synthesize the second-messenger cyclic GMP | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Homo sapiens | guanylyl cyclase receptors synthesize the second-messenger cyclic GMP | 3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | Homo sapiens | isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart, overview | ? | - |
? | |
additional information | Mus musculus | isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium | ? | - |
? | |
additional information | Homo sapiens | isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification, overview | ? | - |
? | |
additional information | Homo sapiens | isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation, overview | ? | - |
? | |
additional information | Homo sapiens | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction, overview | ? | - |
? | |
additional information | Homo sapiens | Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozymes GC-D and GC-G appear to be pseudogenes in the human, role of alterations of these ligand/receptor systems in human diseases, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes GC-D, GC-E, and GC-G | - |
Homo sapiens | P16066 | isozyme GC-A; isozyme GC-A | - |
Homo sapiens | P20594 | GC-B; isozyme GC-B | - |
Homo sapiens | P25092 | isozyme GC-C | - |
Homo sapiens | P51841 | isozyme GC-F; isozyme GC-F | - |
Mus musculus | - |
isozymes GC-A to GC-G | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | isozymes GC-A | Mus musculus | - |
artery | isozymes GC-A | Homo sapiens | - |
endochondral bone | isozyme GC-B | Mus musculus | - |
endochondral bone | isozyme GC-B | Homo sapiens | - |
epithelial cell | isozyme GC-C | Mus musculus | - |
epithelial cell | isozyme GC-C | Homo sapiens | - |
heart | isozymes GC-A | Mus musculus | - |
heart | isozymes GC-A | Homo sapiens | - |
intestine | isozyme GC-C | Homo sapiens | - |
intestine | isozymes GC-C and GC-G | Mus musculus | - |
kidney | isozyme GC-G | Mus musculus | - |
lung | isozyme GC-G | Mus musculus | - |
additional information | GC-G has a broad tissue distribution in rodents | Mus musculus | - |
olfactory neuroepithelium | isozyme GC-D is exclusively expressed in the olfactory neuroepithelium in rodents | Mus musculus | - |
photoreceptor cell | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina | Mus musculus | - |
photoreceptor cell | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina | Homo sapiens | - |
retina | isozyme GC-E | Homo sapiens | - |
retina | isozyme GC-F | Homo sapiens | - |
retina | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina | Mus musculus | - |
retina | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina | Homo sapiens | - |
skeletal muscle | isozyme GC-G | Mus musculus | - |
sperm | isozyme GC-G | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | guanylyl cyclase receptors synthesize the second-messenger cyclic GMP | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | guanylyl cyclase receptors synthesize the second-messenger cyclic GMP | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart, overview | Homo sapiens | ? | - |
? | |
additional information | isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium | Mus musculus | ? | - |
? | |
additional information | isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification, overview | Homo sapiens | ? | - |
? | |
additional information | isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation, overview | Homo sapiens | ? | - |
? | |
additional information | isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction, overview | Homo sapiens | ? | - |
? | |
additional information | Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozymes GC-D and GC-G appear to be pseudogenes in the human, role of alterations of these ligand/receptor systems in human diseases, overview | Homo sapiens | ? | - |
? | |
additional information | structure and functions of membrane guanylate cyclase isozymes, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | isozyme GC-A has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Homo sapiens |
More | isozyme GC-B has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Homo sapiens |
More | isozyme GC-C has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Homo sapiens |
More | isozyme GC-F has a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Homo sapiens |
More | isozymes GC-A to GC-G share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Mus musculus |
More | isozymes GC-D, GC-E, to GC-G share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
membrane guanylyl cyclase receptor | - |
Mus musculus |
membrane guanylyl cyclase receptor | - |
Homo sapiens |