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ATP + acetyl-CoA + HCO3-
?
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + ?
-
at 3% the velocity compared to propanoyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
?
-
key enzyme of the 3-hydroxypropanoate cycle
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (2S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
ATP + propionyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
preferred substrate
-
-
?
ATP + succinyl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
?
butyryl-CoA + CO2
?
-
-
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
additional information
?
-
acetyl-CoA + CO2

?
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
acetyl-CoA + CO2
?
the wild type enzyme shows no activity with acetyl-CoA, but mutant enzyme D422I does
-
-
?
ATP + acetyl-CoA + HCO3-

ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at a rate 1.5% that obtained for propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no other acetyl-CoA carboxylase detected in this organism
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at 0.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + butanoyl-CoA + HCO3-

ADP + phosphate + ?
-
-
-
-
?
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
-
at 5.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-

ADP + phosphate + ?
-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-

ADP + phosphate + (S)-methylmalonyl-CoA
the bifunctional enzyme also catalyzes the carboxylation of acetyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for long-chain fatty acids, polyketides and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
important for polyketide and fatty acid synthesis
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-

ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
GTP + propanoyl-CoA + HCO3-

GDP + phosphate + (S)-methylmalonyl-CoA
-
10% of the activity with ATP
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
-
10% of the activity with ATP
-
?
propionyl-CoA + CO2

(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2

(S)-methylmalonyl-CoA
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
-
-
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
-
-
-
-
?
UTP + propanoyl-CoA + HCO3-

UDP + phosphate + (S)-methylmalonyl-CoA
-
40% of the activity with ATP
-
?
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
-
40% of the activity with ATP
-
?
additional information

?
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
enzyme may play an important role in the biosynthesis of rifamycin as well as in the degradation of various amino acids
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
methylmalonyl-CoA, malonyl-CoA, isobutyryl-CoA, and isovaleryl-CoA are not metabolized
-
?
additional information
?
-
-
required for development of Myxococcus xanthus. The dcm-1 mutant, which is deficient in propanoyl-CoA carboxylase is unable to form fruiting bodies and spores
-
-
?
additional information
?
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
acetyl-CoA is not well converted to malonyl-CoA
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.