Information on EC 6.2.1.24 - phytanate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.24
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
6.2.1.24
-
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RECOMMENDED NAME
GeneOntology No.
phytanate-CoA ligase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
phytanate:CoA ligase (AMP-forming)
Not identical with EC 6.2.1.20 long-chain-fatty-acid---[acyl-carrier-protein] ligase.
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CAS REGISTRY NUMBER
COMMENTARY hide
105238-50-4
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + phytanate + CoA
?
show the reaction diagram
ATP + phytanate + CoA
AMP + diphosphate + phytanoyl-CoA
show the reaction diagram
CTP + phytanate + CoA
CMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
low activity compared to ATP
-
-
-
GTP + phytanate + CoA
GMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
low activity compared to ATP
-
-
-
ITP + phytanate + CoA
IMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
low activity compared to ATP
-
-
-
UTP + phytanate + CoA
UMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
low activity compared to ATP
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + phytanate + CoA
?
show the reaction diagram
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
absolutely required, optimal concentration: 60 mM, inhibition at high concentrations
Mn2+
-
can replace Mg2+ at 5 mM, inhibition at high concentrations
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AMP
-
11 mM, 50% inhibition
iodoacetic acid
-
75 mM, 100% inhibition
NEM
-
10 mM, 87% inhibition
palmitic acid
-
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0286
phytanic acid
-
-
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
AMP
-
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.7
-
Tris-HCl buffer
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
skin, cell culture
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45
-
t1/2: 3-5 min
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LINKS TO OTHER DATABASES (specific for EC-Number 6.2.1.24)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)