Any feedback?
Information on EC 6.3.2.25 - tubulin-tyrosine ligase
for references in articles please use BRENDA:EC6.3.2.25Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
6.3.2.25 tubulin-tyrosine ligaseIUBMB Comments
L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
Specify your search results
Word Map
- 6.3.2.25
- microtubule
-
detyrosinated
-
hardware
-
non-sentinel
-
d-roms
-
polyglutamylation
- analysis
- synthesis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
ttl, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin:tyrosine ligase, tyrosyltubulin ligase, ttlase, tubulin-tyrosine-ligase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Synthetase, tubulin-tyrosine
-
-
-
-
TTL
TTLase
-
-
-
-
tubulin tyrosine ligase
tubulin-tyrosine ligase
Tubulin:tyrosine ligase
-
-
-
-
Tyrosyltubulin ligase
-
-
-
-
TTL
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate
random sequential mechanism
-
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate
reaction mechanism, structure-function analysis, overview
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
formation of peptide bond
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
alpha-tubulin:L-tyrosine ligase (ADP-forming)
L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
60321-03-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-tubulin + ADP + phosphate
ATP + detyrosinated alpha-tubulin + L-tyrosine
-
-
-
-
r
ATP + detyrosinated alpha-tubulin + 3-fluoro-Tyr
?
-
tubulin covalently labeled with 3-fluoro-Tyr is competient to polimerize into microtubules
-
-
?
ATP + detyrosinated alpha-tubulin + 3-nitro-L-tyrosine
nitrotyrosinated alpha-tubulin + ADP + phosphate
ATP + peptide of detyrosinated alpha tubulin + Tyr
peptide of alpha-tubulin + ADP + phosphate
-
peptides ending like alpha-tubulin with the sequence Gly-Glu-Glu are optimally tyrosinated once a peptide length of 12 residues is reached. The carboxy-terminal tetradecapeptide of detyrosinated alpha-tubulin acts as substrate at 50fold lower efficiency than alphabeta-tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + 3-nitro-L-tyrosine
nitrotyrosinated alpha-tubulin + ADP + phosphate
-
-
-
-
ir
ATP + detyrosinated alpha-tubulin + 3-nitro-L-tyrosine
nitrotyrosinated alpha-tubulin + ADP + phosphate
-
-
-
-
ir
ATP + detyrosinated alpha-tubulin + 3-nitro-L-tyrosine
nitrotyrosinated alpha-tubulin + ADP + phosphate
-
35fold lower affinity for nitrotyrosine than for L-tyrosine, nitrotyrosine is incoorporated into the C-terminus
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational modification of tubulin with potential significance for the regulation of microtubule assembly or function
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
activity increases from the embryonic stage to the fourth larval stage L4, decreases from L4 to adult and to aged nematodes with only qualitative alterations in substrate specificity
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
tyrosinates Crithidia tubulin but not brain tubulin and is specific for the alpha chain
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
the enzyme plays a vital role in neuronal organization
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
the enzyme plays a vital role in neuronal organization
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
r
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
turkey erythrocyte tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
r
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
tubuline alpha/beta-dimers, no activity with tyrosinate polymerized microtubules in which the tubulin subunits adopt a straighter configuration
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
tubulin tyrosination is a major factor affecting the recruitment of cytoskeleton-associated protein glycine-rich proteins at microtubule plus ends
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
additional information
?
-
-
full-length stathmin and tubulin tyrosine ligase compete for binding to tubulin and fail to make a stable tubulin:stathmin:tubulin tyrosine ligase triple complex in solution
-
-
?
additional information
?
-
-
the testis-specific apoptosis related gene TTL.6 (member of the tubulin-tyrosine ligase family) undergoes adaptive evolution in the lineage leading to humans
-
-
?
additional information
?
-
-
microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview
-
-
?
additional information
?
-
-
full-length stathmin and tubulin tyrosine ligase compete for binding to tubulin and fail to make a stable tubulin:stathmin:tubulin tyrosine ligase triple complex in solution
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational modification of tubulin with potential significance for the regulation of microtubule assembly or function
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
activity increases from the embryonic stage to the fourth larval stage L4, decreases from L4 to adult and to aged nematodes with only qualitative alterations in substrate specificity
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
?
-
posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
the enzyme plays a vital role in neuronal organization
-
-
?
ATP + detyrosinated alpha-tubulin + L-Tyr
alpha-tubulin + ADP + phosphate
-
the enzyme plays a vital role in neuronal organization
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
tubuline alpha/beta-dimers, no activity with tyrosinate polymerized microtubules in which the tubulin subunits adopt a straighter configuration
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
tubulin tyrosination is a major factor affecting the recruitment of cytoskeleton-associated protein glycine-rich proteins at microtubule plus ends
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
?
ATP + detyrosinated alpha-tubulin + L-tyrosine
alpha-tubulin + ADP + phosphate
-
-
-
-
?
additional information
?
-
-
the testis-specific apoptosis related gene TTL.6 (member of the tubulin-tyrosine ligase family) undergoes adaptive evolution in the lineage leading to humans
-
-
?
additional information
?
-
-
microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
required for the N-formyl-Met-Leu-Phe-induced and the antibiotic A23187-induced stimulation
KCl
Mg2+
MgCl2
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(1R,4aS,6R,8S)-6,8-dihydroxy-5-[(3E)-5-hydroxy-5-(3-hydroxy-5-oxo-2,5-dihydrofuran-2-yl)-3-methylpent-3-en-1-yl]-4a,6-dimethyldecahydronaphthalene-1-carboxylic acid
-
increases the non-tyrosinatable form of alpha-tubulin in human cancer cell cultures indicating to act as an inhibitor of TTL
3-nitro-L-tyrosine
-
50% inhibition of tyrosine incorporation at 50fold higher concentrations of nitrotyrosine
ADP
-
competitive with respect to ATP, non-competitive with respect to tubulin and L-Tyr
stathmin
-
inhibits the enzyme's tubulin tyrosination activity in vitro suggesting either that tubulin tyrosine ligase and stathmin have a partially overlapping footprint on the tubulin dimer or that stathmin induces a tubulin conformation incompatible with stable tubulin tyrosine ligase binding
-
stathmin
-
inhibits the enzyme's tubulin tyrosination activity in vitro suggesting either that tubulin tyrosine ligase and stathmin have a partially overlapping footprint on the tubulin dimer or that stathmin induces a tubulin conformation incompatible with stable tubulin tyrosine ligase binding
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
A23187
-
Ca2+ is required for the N-formyl-Met-Leu-Phe-induced and the A23187-induced stimulation
N-Formyl-Met-Leu-Phe
-
Ca2+ is required for the N-formyl-Met-Leu-Phe-induced and the A23187-induced stimulation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Agammaglobulinemia
[Study on Kveim's test. Positive tests in agammaglobulinemia. Comparison with TTL in presence of Kveim's antigen]
Ameloblastoma
Immunohistochemical demonstration of keratin in ameloblastoma as an indication of tumor differentiation.
Breast Neoplasms
Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay.
Breast Neoplasms
Role of total tumour load of sentinel lymph node on survival in early breast cancer patients.
Breast Neoplasms
[Comparative study of the lymphocyte surface receptors isolated from the blood and tissue of malignant tumors]
Colorectal Neoplasms
Diagnostic value of thiols, paraoxonase 1, arylesterase and oxidative balance in colorectal cancer in human.
Coma
Tilt-to-length noise coupled by wavefront errors in the interfering beams for the space measurement of gravitational waves.
Confusion
Four transthyretin-like genes of the migratory plant-parasitic nematode Radopholus similis: members of an extensive nematode-specific family.
Dermatitis, Allergic Contact
[Skin and laboratory tests: comparison of the epicutaneous patch test with the TTL and LIF tests in the diagnosis of medicamentous allergic contact dermatitis]
Glioblastoma
The Prognostic Value of CD133 in Predicting the Relapse and Recurrence Pattern of High-Grade Gliomas on MRI: A Meta-Analysis.
Glioma
The Prognostic Value of CD133 in Predicting the Relapse and Recurrence Pattern of High-Grade Gliomas on MRI: A Meta-Analysis.
Hypersensitivity
[Delayed allergic reaction to amlodipine with a positive lymphocyte transformation test].
Intervertebral Disc Degeneration
MRI analysis of the ISOBAR TTL internal fixation system for the dynamic fixation of intervertebral discs: a comparison with rigid internal fixation.
Intervertebral Disc Degeneration
Short-Term Therapeutic Efficacy of the Isobar TTL Dynamic Internal Fixation System for the Treatment of Lumbar Degenerative Disc Diseases.
Intervertebral Disc Displacement
[Influence of isobar ttl dynamic internal fixation system on adjacent segment degeneration by mri measurement of lumbar nucleus pulposus volume].
Leishmaniasis, Visceral
[Study of cellular immunity in patients with Mediterranean visceral leishmaniasis]
Leukemia
Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.
Lung Neoplasms
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case-cohort study.
Lung Neoplasms
[Comparative study of the lymphocyte surface receptors isolated from the blood and tissue of malignant tumors]
Neoplasm Metastasis
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Neoplasm Metastasis
Intraoperative Nomograms, Based on One-Step Nucleic Acid Amplification, for Prediction of Non-sentinel Node Metastasis and Four or More Axillary Node Metastases in Breast Cancer Patients with Sentinel Node Metastasis.
Neoplasm Metastasis
Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients.
Neoplasm Metastasis
One-step nucleic acid amplification assay for intraoperative prediction of advanced axillary lymph node metastases in breast cancer patients with sentinel lymph node metastasis.
Neoplasm Metastasis
Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay.
Neoplasm Metastasis
Safety and oncological efficacy of bilateral recurrent laryngeal nerve lymph-node dissection after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a propensity-matched analysis.
Neoplasm Metastasis
Total tumor load assessed by one-step nucleic acid amplification assay as an intraoperative predictor for non-sentinel lymph node metastasis in breast cancer.
Neoplasms
Activity of paclitaxel liposome formulations against human ovarian tumor xenografts.
Neoplasms
Blood markers of oxidative stress are strongly associated with poorer prognosis in colorectal cancer patients.
Neoplasms
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Neoplasms
Intraoperative Nomograms, Based on One-Step Nucleic Acid Amplification, for Prediction of Non-sentinel Node Metastasis and Four or More Axillary Node Metastases in Breast Cancer Patients with Sentinel Node Metastasis.
Neoplasms
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Neoplasms
Molecularly determined total tumour load in lymph nodes of stage I-II colon cancer patients correlates with high-risk factors. A multicentre prospective study.
Neoplasms
Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients.
Neoplasms
Nomogram to predict non-sentinel lymph node status using total tumor load determined by one-step nucleic acid amplification: first report from Thailand.
Neoplasms
Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications.
Neoplasms
Role of total tumour load of sentinel lymph node on survival in early breast cancer patients.
Neoplasms
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case-cohort study.
Neoplasms
Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead.
Neoplasms
The Prognostic Value of CD133 in Predicting the Relapse and Recurrence Pattern of High-Grade Gliomas on MRI: A Meta-Analysis.
Neoplasms
The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.
Neoplasms
The use of onestep nucleic acid amplification (OSNA) and tumour related factors in the treatment of axillary breast cancer: A predictive model.
Neoplasms
Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer.
Neoplasms
Total tumor load assessed by one-step nucleic acid amplification assay as an intraoperative predictor for non-sentinel lymph node metastasis in breast cancer.
Neoplasms
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Neoplasms
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.
Neoplasms
[Comparative study of the lymphocyte surface receptors isolated from the blood and tissue of malignant tumors]
Neoplastic Cells, Circulating
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Neuroblastoma
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Pheochromocytoma
NF-?B inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.
Prostatic Neoplasms
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case-cohort study.
Spondylolisthesis
Posterior Dynamic Stabilization with Direct Pars Repair via Wiltse Approach for the Treatment of Lumbar Spondylolysis: The Application of a Novel Surgery.
Spondylolysis
Posterior Dynamic Stabilization with Direct Pars Repair via Wiltse Approach for the Treatment of Lumbar Spondylolysis: The Application of a Novel Surgery.
Spondylolysis
[Clinical outcome of ISOBAR TTL dynamic stabilization with pars bone grafting for treatment of lumbar spondylolysis].
Stroke
Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies.
Varicose Veins
Per-rectal portal scintigraphy as an alternative measure of hepatic venous pressure gradient in chronic liver disease: A preliminary report.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE