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Literature summary for 6.3.2.25 extracted from
- Tubulin-tyrosine ligase (TTL)-mediated increase in tyrosinated alpha-tubulin in injured axons is required for retrograde injury signaling and axon regeneration (2015), J. Biol. Chem., 290, 14765-14775 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| axon | peripheral axon | Mus musculus | 30424 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TTL | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tubulin-tyrosine ligase TTL is required to increase the levels of tyrosinated alpha-tubulin at an axon injury site and plays an important role in injury signaling. Preventing the injury-induced increase in tyrosinated alpha-tubulin by knocking down TTL impairs retrograde organelle transport and delays activation of the pro-regenerative transcription factor c-Jun. In the absence of TTL, axon regeneration is reduced severely | Mus musculus |
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Release 2023.1 (January 2023)
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