EC Number   |
Natural Substrates |
|---|
   6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-Tyr |
the enzyme plays a vital role in neuronal organization |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-Tyr |
activity increases from the embryonic stage to the fourth larval stage L4, decreases from L4 to adult and to aged nematodes with only qualitative alterations in substrate specificity |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-Tyr |
posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-Tyr |
terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-Tyr |
posttranslational modification of tubulin with potential significance for the regulation of microtubule assembly or function |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-tyrosine |
- |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-tyrosine |
tubulin tyrosination is a major factor affecting the recruitment of cytoskeleton-associated protein glycine-rich proteins at microtubule plus ends |
| 6.3.2.25 | ATP + detyrosinated alpha-tubulin + L-tyrosine |
tubuline alpha/beta-dimers, no activity with tyrosinate polymerized microtubules in which the tubulin subunits adopt a straighter configuration |
| 6.3.2.25 | more |
the testis-specific apoptosis related gene TTL.6 (member of the tubulin-tyrosine ligase family) undergoes adaptive evolution in the lineage leading to humans |
| 6.3.2.25 | more |
microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview |
