EC Number   |
Protein Variants |
Reference |
|---|
   6.3.2.25 | E331Q |
site-directed mutagenesis, catalytically inactive mutant |
728025 |
| 6.3.2.25 | H54A |
site-directed mutagenesis, the mutant enzyme shows moderately reduced binding to tubulin dimers |
728025 |
| 6.3.2.25 | more |
neurons lacking MAP1B, when exposed to drugs that reversibly depolymerize microtubules, do not fully recover tyrosinated microtubules upon drug removal |
686295 |
| 6.3.2.25 | R36E |
site-directed mutagenesis, the mutant enzyme shows strongly reduced binding to tubulin dimers |
728025 |
| 6.3.2.25 | R51A |
site-directed mutagenesis, the mutant enzyme shows moderately reduced binding to tubulin dimers |
728025 |
| 6.3.2.25 | R51A/H54A |
site-directed mutagenesis, the mutant enzyme shows strongly reduced binding to tubulin dimers |
728025 |
| 6.3.2.25 | R66E |
site-directed mutagenesis, the mutant enzyme shows strongly reduced binding to tubulin dimers |
728025 |
| 6.3.2.25 | S152E |
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to the wild-type enzyme |
728025 |
| 6.3.2.25 | S76E |
site-directed mutagenesis, the mutant is comparable to the wild-type enzyme |
728025 |
