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Literature summary for 6.3.2.25 extracted from

  • Utreras, E.; Jimenez-Mateos, E.M.; Contreras-Vallejos, E.; Tortosa, E.; Perez, M.; Rojas, S.; Saragoni, L.; Maccioni, R.B.; Avila, J.; Gonzalez-Billault, C.
    Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination (2008), Dev. Neurosci., 30, 200-210.
    View publication on PubMed
Search for more literature for 6.3.2.25

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged TTL in Escherichia coli strain BL21, co-expression of TTL with MAP1B in COS-7 cells inducing an increase in tyrosinated microtubules Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information neurons lacking MAP1B, when exposed to drugs that reversibly depolymerize microtubules, do not fully recover tyrosinated microtubules upon drug removal Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
 Mus musculus 5874
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + detyrosinated alpha-tubulin + L-tyrosine Mus musculus
-
 alpha-tubulin + ADP + phosphate
-
 ?
additional information Mus musculus microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged enzyme from Escherichia coli strain BL21 by glutathione affinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
Neuro-2a cell
-
 Mus musculus
-
neuroblastoma cell
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + detyrosinated alpha-tubulin + L-tyrosine
-
 Mus musculus alpha-tubulin + ADP + phosphate
-
 ?
additional information microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
TTL
-
 Mus musculus
tubulin tyrosine ligase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus