Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + detyrosinated alpha-tubulin + L-Tyr | Crithidia fasciculata | terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules | ? | - |
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Organism | UniProt | Comment | Textmining |
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Crithidia fasciculata | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + detyrosinated alpha-tubulin + L-Tyr | tyrosinates Crithidia tubulin but not brain tubulin and is specific for the alpha chain | Crithidia fasciculata | alpha-tubulin + ADP + phosphate | - |
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ATP + detyrosinated alpha-tubulin + L-Tyr | terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules | Crithidia fasciculata | ? | - |
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