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Literature summary for 6.3.2.25 extracted from
- Steady-state kinetic mechanism of bovine brain tubulin:tyrosine ligase (1992), Biochem. J., 286, 243-251.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | competitive with respect to ATP, non-competitive with respect to tubulin and L-Tyr | Bos taurus |  |
| AMP | - |
Bos taurus | |
| L-hydroxyphenylalanine | - |
Bos taurus | |
| NEM | substrate protects | Bos taurus | |
| phosphate | very weak | Bos taurus | |
| tyrosinated tubulin | very weak | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0019 | - |
untyrosinated tubulin | - |
Bos taurus | |
| 0.014 | - |
ATP | - |
Bos taurus | |
| 0.017 | - |
L-Tyr | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate | random sequential mechanism | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + detyrosinated alpha-tubulin + L-tyrosine | - |
Bos taurus | alpha-tubulin + ADP + phosphate | - |
r | |
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Release 2023.1 (January 2023)
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