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Literature summary for 6.3.2.61 extracted from

  • Regnard, C.; Fesquet, D.; Janke, C.; Boucher, D.; Desbruyeres, E.; Koulakoff, A.; Insina, C.; Travo, P.; Edde, B.
    Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase (2003), J. Cell Sci., 116, 4181-4190 .
    View publication on PubMed
Search for more literature for 6.3.2.61

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction, higher activity compared to beta-tubulin [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain highest expression Mus musculus
-
colon
-
 Mus musculus
-
gut
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
lung
-
 Mus musculus
-
muscle
-
 Mus musculus
-
ovary
-
 Mus musculus
-
PCC7-AzaR1 1009 cell
-
 Mus musculus
-
small intestine
-
 Mus musculus
-
testis
-
 Mus musculus
-
thymus lowest expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate overall reaction, higher activity compared to beta-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate overall reaction Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Subunits

Subunits Comment Organism
multimer x * 8000 + x * 50000 + x * 32000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
PGS1 subunit Mus musculus
TPG
-
 Mus musculus
tubulin polyglutamylase
-
 Mus musculus