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Information on EC - GMP synthase (glutamine-hydrolysing)

for references in articles please use BRENDA:EC6.3.5.2
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IUBMB Comments
Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia.
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The enzyme appears in viruses and cellular organisms
cgsA, di-GMP synthase A, GATase, Glutamine amidotransferase, GMP synthase, GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase, GMP synthetase (glutamine hydrolysing), GMPS, GUA, more
ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
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ATP + XMP + NH3 = AMP + diphosphate + GMP
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L-glutamine + H2O = L-glutamate + NH3
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