Ligand XMP

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Basic Ligand Information

Molecular Structure
Picture of XMP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H13N4O9P
XMP
DCTLYFZHFGENCW-UUOKFMHZSA-N
Synonyms:
(9-D-ribosylxanthine)-5'-phosphate, 5'-2,3-dihydroxanthylic acid, 5'-XMP, 9-(5-phospho-beta-D-ribosyl)xanthine, 9-D-ribosylxanthine-5'-phosphate, xanthosine-5'-phosphate, xanthosine 5'-monophosphate, xanthosine 5'-phosphate, xanthosine monophosphate, xanthosine phosphate


Show all pahtways known for Show all BRENDA pathways known for XMP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
XTP + H2O = XMP + diphosphate
show the reaction diagram
-
-
XDP + H2O = XMP + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (55 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
show the reaction diagram
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XMP + (phosphate)n+1 = XDP + (phosphate)n
show the reaction diagram
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ATP + XMP = ADP + XDP
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (102 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate = xanthosine 5'-phosphate + diphosphate
show the reaction diagram
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ATP + xanthosine = ADP + XMP
show the reaction diagram
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GMP + H2O = XMP + NH3
show the reaction diagram
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P1,P4-bis(5'-xanthosyl) tetraphosphate + H2O = XTP + XMP
show the reaction diagram
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XDP + H2O = XMP + phosphate
show the reaction diagram
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XDP + H2O = XMP + phosphate
show the reaction diagram
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XTP + H2O = XMP + diphosphate
show the reaction diagram
-
-
xanthosine 5'-triphosphate + H2O = xanthosine 5'-monophosphate + diphosphate
show the reaction diagram
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XDP + H2O = XMP + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight activation
-
0.4 mM, residual enzyme activity 113%
-
enhances activity
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Inhibitor in Enzyme-catalyzed Reactions (142 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 30-32% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (286 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (19 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.31
-
at pH 8.9 and 25C

KM Value (32 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (28 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0012
-
-
1.2
-
-
0.022
-
Kis

References & Links

Links to other databases for XMP

ChEBI
PubChem
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PubChem