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62 kDa RNA-binding protein
bacterial type seryl-tRNA synthetase
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bMbSerRS
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bacterial type
methanogenic type seryl-tRNA synthetase
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methanogenic-type SerRS
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methanogenic-type SerRSs
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methanogenic-type seryl-tRNA synthetase
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Serine transfer RNA synthetase
Seryl-transfer ribonucleate synthetase
Seryl-transfer ribonucleic acid synthetase
Seryl-transfer RNA synthetase
seryl-tRNA synthetase 1
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seryl-tRNA synthetase 2
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seryl-tRNA-synthetase
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subclass IIa dimeric SerRS
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Synthetase, seryl-transfer ribonucleate
tRNASer/seryl-tRNA synthetase
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62 kDa RNA-binding protein

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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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62 kDa RNA-binding protein
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mMbSerRS

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mMbSerRS
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methanogenic type
mtSerRS

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SARS

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Serine transfer RNA synthetase

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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine transfer RNA synthetase
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Serine translase

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Serine--tRNA ligase

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SerRS

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SerRS
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two different types: bacterial-type SerRS and highly divergent SerRS
SerRS2

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SerRSmt

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serS

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SERSEC

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seryl tRNA synthetase

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seryl tRNA synthetase
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seryl tRNA synthetase
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Seryl-transfer ribonucleate synthetase

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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleic acid synthetase

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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer RNA synthetase

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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-transfer RNA synthetase
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Seryl-tRNA synthetase

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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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STS

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Synthetase, seryl-transfer ribonucleate

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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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Synthetase, seryl-transfer ribonucleate
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ttSerRS

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TT_C0520

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VlmL

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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer

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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
reaction mechanism
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
catalytic mechanism, specificity of substrate binding is mediated by the amino acids in motif 2 loop
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
subtrate recognition mechanism
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzymediffers considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
tRNA recoginition mechanism, dual recognition mode for isoacceptors, the mitochondrial isozyme specifically recognizes the TPiC loop sequence in each isoacceptor
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
tRNA substrate discrimination mechanism
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2'-dATP + L-serine + tRNASer
2'-dAMP + diphosphate + L-seryl-tRNASer
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?
2-bromoadenosine 5'-triphosphate + L-serine + tRNASer
2-bromoadenosine 5'-monophosphate + diphosphate + L-seryl-tRNASer
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?
2-chloroadenosine 5'-triphosphate + L-serine + tRNASer
2-chloroadenosine 5'-monophosphate + diphosphate + L-seryl-tRNASer
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?
3'-NH2-ATP + L-serine + tRNASer
3'-NH2-AMP + diphosphate + L-seryl-tRNASer
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?
AMP + diphosphate + L-seryl-tRNASer
ATP + L-serine + tRNASer
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r
ATP + DL-serine hydroxamate + tRNASer
?
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very weak activity
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?
ATP + L-cysteine + tRNASer
AMP + diphosphate + L-cysteinyl-tRNASer
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very weak activity
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?
ATP + L-serine + Fusaro tRNAPyl
AMP + diphosphate + L-seryl-Fusaro tRNAPyl
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Methanosarcina barkeri Fusaro tRNApyrrolysine (tRNAPyl) can be misacylated with serine by the Methanosarcina barkeri bacterial-type seryl-tRNA synthetase in vitro and in vivo in Escherichia coli. Compared to the Methanosarcina barkeri Fusaro tRNA, the Methanosarcina barkeri MS tRNAPyl contains two base changes: a G3:U70 pair
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?
ATP + L-serine + tRNAPyl
AMP + diphosphate + L-seryl-tRNAPyl
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
ATP + L-serine + tRNASec mutant without anticodon arm
?
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?
ATP + L-serine + tRNASecUCA
AMP + diphosphate + L-seryl-tRNASecUCA
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SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins
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?
ATP + L-serine + tRNASer
?
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
ATP + L-serine + tRNASer (Escherichia coli)
AMP + diphosphate + L-seryl-tRNASer (Escherichia coli)
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?
ATP + L-serine + tRNASer (Saccharomyces cerevisiae)
AMP + diphosphate + L-seryl-tRNASer (Saccharomyces cerevisiae)
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?
ATP + L-serine + tRNASer mutant without anticodon arm
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?
ATP + L-serine + tRNASer(CGA)
AMP + diphosphate + L-seryl-tRNASer(CGA)
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?
ATP + L-serine + tRNASer(GCU)
AMP + diphosphate + L-seryl-tRNASer(GCU)
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?
ATP + L-serine + tRNASer(GGA)
AMP + diphosphate + L-seryl-tRNASer(GGA)
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?
ATP + L-serine + tRNASer-C-C-2'dA
AMP + diphosphate + L-seryl-tRNASer-C-C-2'dA
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?
ATP + L-serine + tRNASer-C-C-A
AMP + diphosphate + L-seryl-tRNASer-C-C-A
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?
ATP + L-serine + tRNASer-C-C-F
AMP + diphosphate + L-seryl-tRNASer-C-C-F
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?
ATP + L-serine + tRNASer-CmCA
AMP + diphosphate + L-seryl-tRNASer-CmCA
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?
ATP + L-serine + tRNASer-I-G-A
AMP + diphosphate + L-seryl-tRNASer-I-G-A
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?
ATP + L-serine + tRNASerCGA
AMP + diphosphate + L-seryl-tRNASerCGA
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?
ATP + L-serine + tRNASerGCU
AMP + diphosphate + L-seryl-tRNASerGCU
ATP + L-serine + tRNASerUGA
AMP + diphosphate + L-seryl-tRNASerUGA
ATP + L-threonine + tRNASer
AMP + diphosphate + L-threonyl-tRNASer
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very weak activity
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?
dATP + L-serine + tRNASer
dAMP + diphosphate + L-seryl-tRNASer
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?
formycin 5'-triphosphate + L-serine + tRNASer
formycin 5'-monophosphate + diphosphate + L-seryl-tRNASer
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?
additional information
?
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ATP + D-Ser + tRNASer

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?
ATP + D-Ser + tRNASer
?
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?
ATP + L-serine + tRNASec

AMP + diphosphate + L-seryl-tRNASec
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selenocysteine-incorporating tRNA wild-type and deletion mutants, secondary structures
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
15.8% activity compared to tRNASer
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
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SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is essential for growth Trypanosoma brucei and is responsible for the serylation of both tRNASer and tRNASec
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is responsible for the serylation of both tRNASer and tRNASec
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins
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?
ATP + L-serine + tRNASer

AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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D-Ser can replace L-Ser in ATP-diphosphate exchange
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the enzyme selectively recognizes tRNASer on the basis of its characteristic tertiary structure rather than the nucleotides specific to tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the enzyme only recognizes cognate tRNA
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
100% activity
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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4 isoacceptors of tRNASer, and tRNASer deletion mutants, secondary structures, the anticodon arms D and T are not involved in tRNA substrate recognition by the enzyme, only in formation of the L-shaped tRNA structure
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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-
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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serylates tRNASer from methanobacteria, Escherichia coli and Saccharomyces cerevisiae
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the seryl-tRNA synthetase recognizes eukaryotic and bacterial tRNASer, in addition to the homologous tRNASer and tRNASec
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer