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Information on EC 6.1.1.11 - serine-tRNA ligase
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6.1.1.11 serine-tRNA ligaseIUBMB Comments
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
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Word Map
- 6.1.1.11
-
raman
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surface-enhanced
- nanoparticles
- silver
- aminoacyl-trna
- aminoacylation
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serylation
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colloid
- selenocysteine
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anticodon
- trnasec
- asprs
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isoacceptors
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aarss
- lysyl-trna
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roughened
- phenylalanyl-trna
- trnatyr
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langmuir-blodgett
- alanyl-trna
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handheld
- albomycins
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citrate-reduced
- molecular biology
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nanostars
- selenophosphate
The enzyme appears in viruses and cellular organisms
Synonyms
serrs, seryl-trna synthetase, seryl trna synthetase, mtserrs, serrs2, mmbserrs, seryl-trna-synthetase, serzmo, methanogenic-type serrs, serrs1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
62 kDa RNA-binding protein
mMbSerRS
mtSerRS
SARS
Serine transfer RNA synthetase
Serine translase
Serine--tRNA ligase
SerRS
SerRS2
SerRSmt
serS
SERSEC
seryl tRNA synthetase
Seryl-transfer ribonucleate synthetase
Seryl-transfer ribonucleic acid synthetase
Seryl-transfer RNA synthetase
Seryl-tRNA synthetase
STS
Synthetase, seryl-transfer ribonucleate
ttSerRS
TT_C0520
VlmL
62 kDa RNA-binding protein
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Serine transfer RNA synthetase
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Serine translase
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Serine--tRNA ligase
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SerRS
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SerRS
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two different types: bacterial-type SerRS and highly divergent SerRS
SerRSmt
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SERSEC
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Seryl-transfer ribonucleate synthetase
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Seryl-transfer ribonucleic acid synthetase
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Seryl-transfer RNA synthetase
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Seryl-tRNA synthetase
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Seryl-tRNA synthetase
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Synthetase, seryl-transfer ribonucleate
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
reaction mechanism
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
catalytic mechanism, specificity of substrate binding is mediated by the amino acids in motif 2 loop
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
subtrate recognition mechanism
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ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
the tRNA recognition mechanism of mammalian mitochondrial enzymediffers considerably from that of its prokaryotic counterpart
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
tRNA recoginition mechanism, dual recognition mode for isoacceptors, the mitochondrial isozyme specifically recognizes the TPiC loop sequence in each isoacceptor
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
tRNA substrate discrimination mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Aminoacylation
esterification
Aminoacylation
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esterification
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
L-serine:tRNASer ligase (AMP-forming)
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
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CAS REGISTRY NUMBER
COMMENTARY
9023-48-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-dATP + L-serine + tRNASer
2'-dAMP + diphosphate + L-seryl-tRNASer
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?
2-bromoadenosine 5'-triphosphate + L-serine + tRNASer
2-bromoadenosine 5'-monophosphate + diphosphate + L-seryl-tRNASer
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-
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?
2-chloroadenosine 5'-triphosphate + L-serine + tRNASer
2-chloroadenosine 5'-monophosphate + diphosphate + L-seryl-tRNASer
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?
3'-NH2-ATP + L-serine + tRNASer
3'-NH2-AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-cysteine + tRNASer
AMP + diphosphate + L-cysteinyl-tRNASer
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very weak activity
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?
ATP + L-serine + Fusaro tRNAPyl
AMP + diphosphate + L-seryl-Fusaro tRNAPyl
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Methanosarcina barkeri Fusaro tRNApyrrolysine (tRNAPyl) can be misacylated with serine by the Methanosarcina barkeri bacterial-type seryl-tRNA synthetase in vitro and in vivo in Escherichia coli. Compared to the Methanosarcina barkeri Fusaro tRNA, the Methanosarcina barkeri MS tRNAPyl contains two base changes: a G3:U70 pair
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?
ATP + L-serine + tRNAPyl
AMP + diphosphate + L-seryl-tRNAPyl
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?
ATP + L-serine + tRNASecUCA
AMP + diphosphate + L-seryl-tRNASecUCA
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SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins
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?
ATP + L-serine + tRNASer (Escherichia coli)
AMP + diphosphate + L-seryl-tRNASer (Escherichia coli)
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?
ATP + L-serine + tRNASer (Saccharomyces cerevisiae)
AMP + diphosphate + L-seryl-tRNASer (Saccharomyces cerevisiae)
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?
ATP + L-serine + tRNASer(CGA)
AMP + diphosphate + L-seryl-tRNASer(CGA)
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?
ATP + L-serine + tRNASer(GCU)
AMP + diphosphate + L-seryl-tRNASer(GCU)
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?
ATP + L-serine + tRNASer(GGA)
AMP + diphosphate + L-seryl-tRNASer(GGA)
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?
ATP + L-serine + tRNASer-C-C-2'dA
AMP + diphosphate + L-seryl-tRNASer-C-C-2'dA
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?
ATP + L-serine + tRNASer-C-C-A
AMP + diphosphate + L-seryl-tRNASer-C-C-A
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?
ATP + L-serine + tRNASer-C-C-F
AMP + diphosphate + L-seryl-tRNASer-C-C-F
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?
ATP + L-serine + tRNASerCGA
AMP + diphosphate + L-seryl-tRNASerCGA
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?
ATP + L-threonine + tRNASer
AMP + diphosphate + L-threonyl-tRNASer
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very weak activity
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?
formycin 5'-triphosphate + L-serine + tRNASer
formycin 5'-monophosphate + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
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selenocysteine-incorporating tRNA wild-type and deletion mutants, secondary structures
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
15.8% activity compared to tRNASer
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
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SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is essential for growth Trypanosoma brucei and is responsible for the serylation of both tRNASer and tRNASec
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is responsible for the serylation of both tRNASer and tRNASec
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?
ATP + L-serine + tRNASec
AMP + diphosphate + L-seryl-tRNASec
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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D-Ser can replace L-Ser in ATP-diphosphate exchange
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the enzyme selectively recognizes tRNASer on the basis of its characteristic tertiary structure rather than the nucleotides specific to tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the enzyme only recognizes cognate tRNA
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
Escherichia coli B / ATCC 11303
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
100% activity
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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4 isoacceptors of tRNASer, and tRNASer deletion mutants, secondary structures, the anticodon arms D and T are not involved in tRNA substrate recognition by the enzyme, only in formation of the L-shaped tRNA structure
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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serylates tRNASer from methanobacteria, Escherichia coli and Saccharomyces cerevisiae
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?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
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the seryl-tRNA synthetase recognizes eukaryotic and bacterial tRNASer, in addition to the homologous tRNASer and tRNASec
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?