Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-acetylglutamate | no requirement for N-acetyl-L-glutamate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-diazo-5-oxonorleucine | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0119 | - |
L-Gln | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requires high concentrations of MgATP2- for optimal activity, half-maximal velocity at 10 mM MgATP2- | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
fibrosarcoma cell | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
liver | fetal | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
mammary carcinoma cell | mammary carcinoma DMBA-1C, DMBA-5A, 205A, R3230AC, RNC-211 | Rattus norvegicus | - |
additional information | rapidly growing tissues, e.g. fetal liver, spleen, and testis have much more carbamoyl-phosphate synthase activity than other tissues testes, e.g. lung, uterus, heart, brain and muscle. Tumors are more active than most normal tissues | Rattus norvegicus | - |
muscle | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
uterus | - |
Rattus norvegicus | - |
Walker carcinoma 256 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | - |
Rattus norvegicus | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | utilizes NH4+ with 600times lower affinity than Gln | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
with either 5 mM Gln or 100 mM NH4+ as substrate | Rattus norvegicus |