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Information on EC - channel-conductance-controlling ATPase

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EC Tree
IUBMB Comments
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The enzyme is also involved in the functioning of other transmembrane channels.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
closed Cl- channel
open Cl- channel
cystic fibrosis transmembrane conductance regulator, cystic fibrosis transmembrane regulator, cftr channel, cftr cl- channel, cystic fibrosis conductance regulator, abcc7, epithelial basolateral chloride conductance regulator, more
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel
show the reaction diagram