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Information on EC 6.2.1.3 - long-chain-fatty-acid-CoA ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.3 long-chain-fatty-acid-CoA ligase
IUBMB Comments
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fatp4, acsl1, fatty acid transport protein, acsl3, long-chain acyl-coa synthetase, acsl5, fatty acyl-coa synthetase, acsl6, faa1p, palmitoyl-coa ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
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