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Synonyms
frataxin, ferrochelatase, heme synthetase, heme synthase, hem15, hemh1, hemh2, ppix ferrochelatase, protoporphyrin ix ferrochelatase, type ii ferrochelatase,
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chelatase, ferro-
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EC 4.99.1.1
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formerly
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ferro-protoporphyrin chelatase
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ferrochelatase II
isoform
heme synthetase
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ambiguous
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host red cell ferrochelatase
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iron chelatase
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ambiguous
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parasite genome-coded ferrochelatase
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protoporhyrin IX ferrochelatase
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protoporphyrin (IX) ferrochelatase
protoporphyrin IX ferrochelatase
FC1
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isoform
FC2
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isoform
FC2
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plastid ferrochelatase two
FC2
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plastid ferrochelatase two mutant
FeC
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FeCH
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ferrochelatase
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ambiguous
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ferrochelatase I
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HEM15
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heme synthase
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ambiguous
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hemH
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HemH1
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HemH2
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PPIX ferrochelatase
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protoheme ferro-lyase
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protoheme ferro-lyase
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protoheme ferrolyase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin (IX) ferrochelatase
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protoporphyrin IX ferrochelatase
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protoporphyrin IX ferrochelatase
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Shew_1140
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Shew_2229
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protoheme + 2 H+ = protoporphyrin + Fe2+
protoheme + 2 H+ = protoporphyrin + Fe2+
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism
protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism
protoheme + 2 H+ = protoporphyrin + Fe2+
catalytic model
protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism: overview
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism: overview
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism: overview
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism: overview
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protoheme + 2 H+ = protoporphyrin + Fe2+
mechanism: overview
protoheme + 2 H+ = protoporphyrin + Fe2+
structural model
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2,4-bisacetal deuteroporphyrin + Fe2+
?
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?
2,4-disulfonic deuteroporphyrin + Fe2+
?
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?
Cd2+-protoporphyrin + H+
protoporphyrin + Cd2+
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poor substrate
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?
Co2+-protoporphyrin + H+
protoporphyrin + Co2+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
deuteroporphyrin + Mn2+
? + H+
in contrast to protoporphyrin IX, deuteroporphyrin lacks the vinyl groups at the 2- and 4-ring positions, and therefore, it is possible to structurally discriminate enzyme-bound (metallated) deuteroporphyrin from any possible heme (protoheme) carryover from the enzyme preparation
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?
deuteroporphyrin + Ni2+
? + H+
the Ni-deuteroporphyrin structure is distinctly different from the Mn-deuteroporphyrin model, despite the only variation in enzyme preparation being the addition of either Ni or Mn
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?
deuteroporphyrin IX + Fe2+
iron-deuteroporphyrin IX + H+
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?
deuteroporphyrin IX + Zn2+
zinc-deuteroporphyrin IX + H+
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?
deuteroporphyrin IX + Zn2+
Zn deuteroporphyrin IX + H+
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in vitro, zinc is the preferred substrate at all concentrations of porphyrin
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?
deuteroporphyrin IX + Zn2+
Zn-deuteroporphyrin IX + H+
Fe2+-2,4-bis-acetal deuteroporphyrin
?
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?
Fe2+-2,4-diacetyldeuteroporphyrin
?
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?
Fe2+-2,4-disulfonate deuteroporphyrin
?
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?
Fe2+-mesoporphyrin IX + H+
mesoporphyrin IX + Fe2+
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?
Fe2+-protoporphyrin + H+
protoporphyrin + Fe2+
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?
hematoporphyrin + Fe2+
?
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?
heme + Zn2+
Zn-protoporphyrin + H+
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?
hemin + H+
mesoporphyrin IX + Zn2+
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r
hemoglobin + Zn2+
Zn-protoporphyrin + H+
mesoporphyrin + Fe2+
mesoheme
pH 8.0
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?
mesoporphyrin + Fe2+
mesoheme + H+
mesoporphyrin + Zn2+
Zn-mesoporphyrin + 2 H+
mesoporphyrin IX + Co2+
cobalt mesoporphyrin IX + 2 H+
mesoporphyrin IX + Fe2+
?
mesoporphyrin IX + Fe2+
Fe-mesoporphyrin IX + 2 H+
mesoporphyrin IX + Fe2+
iron mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Fe2+
mesoheme + 2 H+
mesoporphyrin IX + ferrous ammonium sulfate
mesoheme + ammonium sulfate
room temperature
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?
mesoporphyrin IX + Zn2+
zinc mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Zn2+
Zn2+-mesoporphyrin + 2 H+
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r
myoglobin + Zn2+
Zn-protoporphyrin + H+
N-methyl mesoporphyrin + Cu2+
?
pH 7.4
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?
N-methyl mesoporphyrin + Zn2+
?
pH 7.4
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?
porphyrin + Fe2+
heme + H+
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?
porphyrin + metal ion
metalloporphyrin
protoheme + H+
protoporphyrin + Fe2+
protoporphyrin + Cu2+
Cu2+-protoporphyrin + H+
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-
?
protoporphyrin + Fe2+
protoheme + 2 H+
protoporphyrin + Fe2+
protoheme + H+
protoporphyrin + Zn2+
Zn2+-protoporphyrin + H+
protoporphyrin IX + Co2+
?
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?
protoporphyrin IX + Co2+
Co2+-protoporphyrin + H+
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?
protoporphyrin IX + Cu2+
?
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protoporphyrin IX + Cu2+
Cu2+-protoporphyrin + H+
Cu2+ is a good substrate
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?
protoporphyrin IX + Fe2+
?
protoporphyrin IX + Fe2+
Fe-protoporphyrin IX + 2 H+
protoporphyrin IX + Fe2+
Fe2+-protoporphyrin IX + 2 H+
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?
protoporphyrin IX + Fe2+
heme + 2 H+
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?
protoporphyrin IX + Fe2+
protoheme + 2 H+
protoporphyrin IX + Fe2+
protoheme IX + 2 H+
protoporphyrin IX + FeCl3
protoheme + HCl
pH 7.5, 37°C
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?
protoporphyrin IX + Ni2+
?
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?
protoporphyrin IX + Zn2+
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protoporphyrin IX + Zn2+
Zn protoporphyrin IX
pH 7.4, room temperature
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?
protoporphyrin IX + Zn2+
Zn-protoporphyrin + H+
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?
protoporphyrin IX + Zn2+
Zn-protoporphyrin IX
protoporphyrin IX + Zn2+
Zn-protoporphyrin IX + H+
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?
protoporphyrin IX + Zn2+
Zn2+-protoporphyrin IX + H+
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?
Sn2+-protoporphyrin + H+
protoporphyrin + Sn2+
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?
Zn2+-mesoporphyrin + H+
mesoporphyrin + Zn2+
Zn2+-protoporphyrin + H+
protoporphyrin + Zn2+
additional information
?
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deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
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?
deuteroporphyrin IX + Zn2+
Zn-deuteroporphyrin IX + H+
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?
deuteroporphyrin IX + Zn2+
Zn-deuteroporphyrin IX + H+
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?
Fe2+-hematoporphyrin
?
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?
Fe2+-hematoporphyrin
?
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Fe2+-hematoporphyrin
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?
Fe2+-hematoporphyrin
?
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?
hemoglobin + Zn2+
Zn-protoporphyrin + H+
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?
hemoglobin + Zn2+
Zn-protoporphyrin + H+
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?
hemoglobin + Zn2+
Zn-protoporphyrin + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Fe2+
mesoheme + H+
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?
mesoporphyrin + Zn2+
Zn-mesoporphyrin + 2 H+
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?
mesoporphyrin + Zn2+
Zn-mesoporphyrin + 2 H+
37°C
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?
mesoporphyrin IX + Co2+
cobalt mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Co2+
cobalt mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Fe2+
?
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?
mesoporphyrin IX + Fe2+
?
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?
mesoporphyrin IX + Fe2+
?
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?
mesoporphyrin IX + Fe2+
?
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?
mesoporphyrin IX + Fe2+
Fe-mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Fe2+
Fe-mesoporphyrin IX + 2 H+
activity measurements were perfomed with a second redox reaction with protoporphyrin IX / protoheme IX as product
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?
mesoporphyrin IX + Fe2+
Fe-mesoporphyrin IX + 2 H+
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?
mesoporphyrin IX + Fe2+
mesoheme + 2 H+
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?
mesoporphyrin IX + Fe2+
mesoheme + 2 H+
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?
mesoporphyrin IX + Fe2+
mesoheme + 2 H+
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?
myoglobin + Zn2+
Zn-protoporphyrin + H+
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?
myoglobin + Zn2+
Zn-protoporphyrin + H+
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?
myoglobin + Zn2+
Zn-protoporphyrin + H+
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?
porphyrin + metal ion
metalloporphyrin
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Fe2+, Zn2+, Co2+
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?
porphyrin + metal ion
metalloporphyrin
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?
porphyrin + metal ion
metalloporphyrin
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Co2+, Fe2+, Zn2+, Ni2+ or Mn2+
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?
porphyrin + metal ion
metalloporphyrin
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Co2+, Fe2+, Zn2+, Ni2+ or Mn2+
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?
porphyrin + metal ion
metalloporphyrin
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Co2+, Fe2+, Zn2+, Ni2+ or Mn2+
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?
protoheme + H+
protoporphyrin + Fe2+
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-
?
protoheme + H+
protoporphyrin + Fe2+
-
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-
-
r
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 to facilitate mitochondrial ferrous iron transfer for erythroid heme biosynthesis
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?
protoporphyrin + Fe2+
protoheme + 2 H+
-
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-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
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?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
4.98.1.1 protoporphyrin ferrochelatase
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