Literature summary for 5.6.1.8 extracted from

Okafor, C.; Liao, R.; Perreault-Micale, C.; Li, X.; Ito, T.; Stepanek, A.; Doye, A.; de Tombe, P.; Gwathmey, J.K.
Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine (2003), Mol. Cell. Biochem., 245, 77-89.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Caffeine	increase in enzyme activity by 4% for non-failing, 11% for idiopathic and 10% ischemic cardiomyopathic hearts	Homo sapiens
DPI201-206	increase in enzyme activity by less than 5% for all preparations	Homo sapiens
MCI-154	increase in enzyme activity by 11% for non-failing, 19% for idiopathic and 24% ischemic cardiomyopathic hearts	Homo sapiens

Application

Application	Comment	Organism
medicine	decrease of enzyme activity in hearts of idiopathic and ischemic cardiomyopathic individuals, MCI-154 and caffeine increased enzyme activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	non-failing, idiopathic and ischemic cardiomyopathic individuals	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	left ventricular myofibril	Homo sapiens	-

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Release 2023.1 (January 2023)